KEGG   ORTHOLOGY: K12077Help
Entry
K12077                      KO                                     

Name
PDK1
Definition
pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
Pathway
HIF-1 signaling pathway
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase
     K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Atypical group
  PDHK family [OT]
   K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5163(PDK1)
PTR: 
459743(PDK1)
PPS: 
100968174(PDK1)
GGO: 
101150048(PDK1)
PON: 
100442853(PDK1)
NLE: 
100601990(PDK1)
MCC: 
697772(PDK1)
MCF: 
102132161(PDK1)
CJC: 
100402844(PDK1)
MMU: 
228026(Pdk1)
RNO: 
116551(Pdk1)
CGE: 
100774056(Pdk1)
NGI: 
HGL: 
101705587(Pdk1)
OCU: 
100351323(PDK1)
TUP: 
102499515(PDK1)
CFA: 
476828(PDK1)
AML: 
UMR: 
103659566(PDK1)
FCA: 
101092705(PDK1)
PTG: 
102960301(PDK1)
BTA: 
528655(PDK1)
BOM: 
102265648(PDK1)
PHD: 
102339076(PDK1)
CHX: 
102186251(PDK1)
OAS: 
101113205(PDK1)
SSC: 
100286871(PDK1)
CFR: 
102518782(PDK1)
BACU: 
103016999(PDK1)
LVE: 
103078387(PDK1)
ECB: 
100064091(PDK1)
MYB: 
102262215(PDK1)
MYD: 
102767099(PDK1)
PALE: 
102883688(PDK1)
MDO: 
100617164(PDK1)
SHR: 
100932777(PDK1)
OAA: 
100084173(PDK1)
GGA: 
425972(PDK1)
MGP: 
APLA: 
101790921(PDK1)
TGU: 
100218846(PDK1)
FAB: 
101812709(PDK1)
PHI: 
102101703(PDK1)
FPG: 
101925003(PDK1)
FCH: 
102050815(PDK1)
CLV: 
102098636(PDK1)
ASN: 
102384931(PDK1)
AMJ: 
102565725(PDK1)
PSS: 
102462980(PDK1)
CMY: 
102942305(PDK1)
ACS: 
100555492(pdk1)
PBI: 
103052758(PDK1)
XLA: 
XTR: 
100497838(pdk1)
DRE: 
555840(pdk1)
TRU: 
MZE: 
OLA: 
XMA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR
  Title
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
  Journal
Curr Biol 9:393-404 (1999)
Reference
  Authors
Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J
  Title
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
  Journal
Mol Cell 44:864-77 (2011)
  Sequence
[hsa:5163]

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