KEGG   ORTHOLOGY: K12409Help
Entry
K12409                      KO                                     
Name
GNE
Definition
bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:5.1.3.14 2.7.1.60]
Pathway
Amino sugar and nucleotide sugar metabolism
Disease
H00147  
Sialuria/ Sialic acid storage disease
H00594  
Distal muscular dystrophies
H00596  
Nonaka distal myopathy (NM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K12409  GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.60  N-acylmannosamine kinase
     K12409  GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.14  UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
     K12409  GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase
BRITE hierarchy
Other DBs
Genes
HSA: 
10020(GNE)
PTR: 
465094(GNE)
PPS: 
GGO: 
PON: 
MCC: 
693525(GNE)
MMU: 
50798(Gne)
RNO: 
114711(Gne)
CFA: 
481607(GNE)
AML: 
FCA: 
101098411(GNE)
BTA: 
782201(GNE)
SSC: 
641344(GNE)
ECB: 
100067216(GNE)
MDO: 
100017383
SHR: 
100922969(GNE)
OAA: 
100075502(GNE)
GGA: 
427285(GNE)
MGP: 
100541275(GNE)
TGU: 
100226686(GNE)
ACS: 
100554566(gne)
XTR: 
780185(gne)
DRE: 
393857(gne)
TRU: 
778010(glcne)
OLA: 
101166451
BFO: 
BRAFLDRAFT_124939
SPU: 
590539(gne)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lucka L, Krause M, Danker K, Reutter W, Horstkorte R
  Title
Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis.
  Journal
FEBS Lett 454:341-4 (1999)
Reference
  Authors
Reinke SO, Hinderlich S
  Title
Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
  Journal
FEBS Lett 581:3327-31 (2007)
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