KEGG   ORTHOLOGY: K12473Help
Entry
K12473                      KO                                     

Name
LDLR
Definition
low-density lipoprotein receptor
Pathway
ko04144  Endocytosis
ko04913  Ovarian steroidogenesis
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04934  Cushing's syndrome
ko04976  Bile secretion
ko04979  Cholesterol metabolism
ko05145  Toxoplasmosis
ko05160  Hepatitis C
Disease
H00155  Familial hypercholesterolemia
H01383  Hyperlipoproteinemia type IIa
H01635  Hyperlipidemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K12473  LDLR; low-density lipoprotein receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K12473  LDLR; low-density lipoprotein receptor
   04925 Aldosterone synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
   04927 Cortisol synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
  Digestive system
   04976 Bile secretion
    K12473  LDLR; low-density lipoprotein receptor
   04979 Cholesterol metabolism
    K12473  LDLR; low-density lipoprotein receptor
 Human Diseases
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K12473  LDLR; low-density lipoprotein receptor
  Infectious diseases
   05160 Hepatitis C
    K12473  LDLR; low-density lipoprotein receptor
   05145 Toxoplasmosis
    K12473  LDLR; low-density lipoprotein receptor
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    K12473  LDLR; low-density lipoprotein receptor
BRITE hierarchy
Other DBs
GO: 0005041
Genes
HSA: 3949(LDLR)
PTR: 455722(LDLR)
PPS: 100974202(LDLR)
GGO: 101124590(LDLR)
PON: 100447659(LDLR)
NLE: 100591481(LDLR)
MCC: 574283(LDLR)
MCF: 102127361(LDLR)
CSAB: 103234364(LDLR)
RRO: 104670517(LDLR)
RBB: 108527932(LDLR)
CJC: 100385319(LDLR)
SBQ: 101052112(LDLR)
MMU: 16835(Ldlr)
RNO: 300438(Ldlr)
CGE: 100689399(Ldlr)
NGI: 103734567(Ldlr)
HGL: 101703463(Ldlr)
CCAN: 109692527(Ldlr)
OCU: 100009086(LDLR)
TUP: 102484417(LDLR)
CFA: 100683160(LDLR)
AML: 100473450(LDLR)
UMR: 103678713(LDLR)
ORO: 101367933(LDLR)
FCA: 101080362(LDLR)
PTG: 102949981(LDLR)
AJU: 106983922(LDLR)
BTA: 281276(LDLR)
BOM: 102268224(LDLR)
BIU: 109561609(LDLR)
PHD: 102334400(LDLR)
CHX: 102186579(LDLR)
OAS: 443535(LDLR)
SSC: 396801(LDLR)
CFR: 102506814(LDLR)
CDK: 105087617(LDLR)
BACU: 103002602(LDLR)
LVE: 103088391(LDLR)
OOR: 101283356(LDLR)
ECB: 100057389(LDLR)
EPZ: 103564902(LDLR)
EAI: 106846613(LDLR)
MYB: 102246709(LDLR)
MYD: 102771350(LDLR)
HAI: 109391592(LDLR)
RSS: 109454388(LDLR)
PALE: 102888790(LDLR)
LAV: 100669109(LDLR)
TMU: 101342003
MDO: 654363(LDLR)
SHR: 100923750(LDLR)
OAA: 100079454(LDLR)
PHI: 106628808(LDLR)
ASN: 102370878(LDLR)
AMJ: 102574674(LDLR)
CMY: 102937401(LDLR)
CPIC: 101932535(LDLR)
ACS: 100554150(ldlr)
PVT: 110077953(LDLR)
PBI: 103053965(LDLR)
GJA: 107105423(LDLR)
XLA: 373644(ldlr.S) 397757(ldlr.L)
XTR: 100495826(ldlr)
NPR: 108798866(LDLR)
DRE: 387529(ldlra)
IPU: 108273208 108278865(ldlr)
AMEX: 103022705(ldlr) 103043840
TRU: 101072134(ldlr)
LCO: 104926679 104932223(ldlr)
NCC: 104943331(ldlr) 104952792
XMA: 102236051 102238173(ldlr)
PRET: 103468275 103468516(ldlr)
NFU: 107376229(ldlr) 107382301
HCQ: 109508411(ldlr) 109511383
BPEC: 110171504(ldlr) 110172564
ELS: 105012136 105013183(ldlr)
SFM: 108926163(ldlr) 108940142
LCM: 102359035(LDLR)
CMK: 103187554(ldlr)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Martinez-Olivan J, Arias-Moreno X, Velazquez-Campoy A, Millet O, Sancho J
  Title
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
  Journal
FEBS J 281:1534-46 (2014)
DOI:10.1111/febs.12721
  Sequence
[hsa:3949]
Reference
PMID:8466528
  Authors
Hoffer MJ, van Eck MM, Petrij F, van der Zee A, de Wit E, Meijer D, Grosveld G, Havekes LM, Hofker MH, Frants RR
  Title
The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.
  Journal
Biochem Biophys Res Commun 191:880-6 (1993)
  Sequence
[mmu:16835]

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