KEGG   ORTHOLOGY: K12473Help
Entry
K12473                      KO                                     

Name
LDLR
Definition
low-density lipoprotein receptor
Pathway
Endocytosis
Ovarian steroidogenesis
Aldosterone synthesis and secretion
Bile secretion
Cholesterol metabolism
Toxoplasmosis
Hepatitis C
Disease
H00155  
Familial hypercholesterolemia
H01383  
Hyperlipoproteinemia type IIa
H01635  
Hyperlipidemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K12473  LDLR; low-density lipoprotein receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K12473  LDLR; low-density lipoprotein receptor
   04925 Aldosterone synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
  Digestive system
   04976 Bile secretion
    K12473  LDLR; low-density lipoprotein receptor
   04979 Cholesterol metabolism
    K12473  LDLR; low-density lipoprotein receptor
 Human Diseases
  Infectious diseases
   05160 Hepatitis C
    K12473  LDLR; low-density lipoprotein receptor
   05145 Toxoplasmosis
    K12473  LDLR; low-density lipoprotein receptor
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    K12473  LDLR; low-density lipoprotein receptor
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3949(LDLR)
PTR: 
455722(LDLR)
PPS: 
100974202(LDLR)
GGO: 
101124590(LDLR)
PON: 
100447659(LDLR)
NLE: 
100591481(LDLR)
MCC: 
574283(LDLR)
MCF: 
102127361(LDLR)
CSAB: 
103234364(LDLR)
RRO: 
104670517(LDLR)
RBB: 
108527932(LDLR)
CJC: 
100385319(LDLR)
SBQ: 
101052112(LDLR)
MMU: 
16835(Ldlr)
RNO: 
300438(Ldlr)
CGE: 
100689399(Ldlr)
NGI: 
103734567(Ldlr)
HGL: 
101703463(Ldlr)
CCAN: 
109692527(Ldlr)
OCU: 
100009086(LDLR)
TUP: 
102484417(LDLR)
CFA: 
100683160(LDLR)
AML: 
100473450(LDLR)
UMR: 
103678713(LDLR)
ORO: 
101367933(LDLR)
FCA: 
101080362(LDLR)
PTG: 
102949981(LDLR)
AJU: 
106983922(LDLR)
BTA: 
281276(LDLR)
BOM: 
102268224(LDLR)
BIU: 
109561609(LDLR)
PHD: 
102334400(LDLR)
CHX: 
102186579(LDLR)
OAS: 
443535(LDLR)
SSC: 
396801(LDLR)
CFR: 
102506814(LDLR)
CDK: 
105087617(LDLR)
BACU: 
103002602(LDLR)
LVE: 
103088391(LDLR)
ECB: 
100057389(LDLR)
EPZ: 
103564902(LDLR)
EAI: 
106846613(LDLR)
MYB: 
102246709(LDLR)
MYD: 
102771350(LDLR)
HAI: 
109391592(LDLR)
RSS: 
109454388(LDLR)
PALE: 
102888790(LDLR)
LAV: 
100669109(LDLR)
TMU: 
MDO: 
654363(LDLR)
SHR: 
100923750(LDLR)
OAA: 
100079454(LDLR)
PHI: 
106628808(LDLR)
ASN: 
102370878(LDLR)
AMJ: 
102574674(LDLR)
CMY: 
102937401(LDLR)
CPIC: 
101932535(LDLR)
ACS: 
100554150(ldlr)
PVT: 
110077953(LDLR)
PBI: 
103053965(LDLR)
GJA: 
107105423(LDLR)
XLA: 
373644(ldlr.S) 397757(ldlr.L)
XTR: 
100495826(ldlr)
NPR: 
108798866(LDLR)
DRE: 
387529(ldlra)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
101072134(ldlr)
TNG: 
LCO: 
NCC: 
104943331(ldlr)
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102359035(LDLR)
CMK: 
103187554(ldlr)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Martinez-Olivan J, Arias-Moreno X, Velazquez-Campoy A, Millet O, Sancho J
  Title
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
  Journal
FEBS J 281:1534-46 (2014)
DOI:10.1111/febs.12721
  Sequence
[hsa:3949]
Reference
PMID:8466528
  Authors
Hoffer MJ, van Eck MM, Petrij F, van der Zee A, de Wit E, Meijer D, Grosveld G, Havekes LM, Hofker MH, Frants RR
  Title
The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.
  Journal
Biochem Biophys Res Commun 191:880-6 (1993)
  Sequence
[hsa:3949]

DBGET integrated database retrieval system