KEGG   ORTHOLOGY: K12618Help
Entry
K12618                      KO                                     

Name
XRN1, SEP1, KEM1
Definition
5'-3' exoribonuclease 1 [EC:3.1.13.-]
Pathway
ko03008  Ribosome biogenesis in eukaryotes
ko03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Translation
   03008 Ribosome biogenesis in eukaryotes
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
  Folding, sorting and degradation
   03018 RNA degradation
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.-  
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
  mRNA degradation factors
   5'-3' decay
    5' exonucleases
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Ribosome biogenesis [BR:ko03009]
 Eukaryotic Type
  Pre-60S particles
   RNases
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Transfer RNA biogenesis [BR:ko03016]
 Eukaryotic Type
  tRNA degradation factors
   Rapid tRNA decay (RTD) pathway factors
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Chromosome [BR:ko03036]
 Eukaryotic Type
  RNA silencing
   piRNA pathway
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
BRITE hierarchy
Genes
HSA: 54464(XRN1)
PTR: 460744(XRN1)
PPS: 100975490(XRN1)
GGO: 101147797(XRN1)
PON: 100449590(XRN1)
NLE: 100597889(XRN1)
MCC: 714497(XRN1)
MCF: 101926618(XRN1)
CSAB: 103241558(XRN1)
RRO: 104674075(XRN1) 104682193
RBB: 108535875(XRN1)
CJC: 100412678(XRN1)
SBQ: 101043520(XRN1)
MMU: 24127(Xrn1)
RNO: 300944(Xrn1)
CGE: 100760243(Xrn1)
NGI: 103752522(Xrn1)
HGL: 101701152(Xrn1)
OCU: 100351589(XRN1)
TUP: 102482614(XRN1)
CFA: 477100(XRN1)
AML: 100464646(XRN1)
UMR: 103678392(XRN1)
ORO: 101369891(XRN1)
FCA: 101097088(XRN1)
PTG: 102948561(XRN1)
AJU: 106982266(XRN1)
BTA: 540834(XRN1)
BOM: 102268763(XRN1)
BIU: 109559563(XRN1)
PHD: 102327924(XRN1)
CHX: 102178771(XRN1)
OAS: 101106821(XRN1)
SSC: 100515927(XRN1)
CFR: 102511588(XRN1)
CDK: 105086327(XRN1)
BACU: 103016273(XRN1)
LVE: 103082255(XRN1)
OOR: 101275029(XRN1)
ECB: 100051335(XRN1)
EPZ: 103541058(XRN1)
EAI: 106838126(XRN1)
MYB: 102249234(XRN1)
MYD: 102768117(XRN1)
HAI: 109390466(XRN1)
RSS: 109459253(XRN1)
PALE: 102889090(XRN1)
LAV: 100661562(XRN1)
TMU: 101341941
MDO: 100013672(XRN1)
SHR: 100934609(XRN1)
OAA: 100077938(XRN1)
GGA: 424778(XRN1)
MGP: 100542331(XRN1)
CJO: 107318069(XRN1)
APLA: 101794979(XRN1)
ACYG: 106036229(XRN1)
TGU: 100232132(XRN1)
GFR: 102032070(XRN1)
FAB: 101808622(XRN1)
PHI: 102109729(XRN1)
PMAJ: 107208804(XRN1)
CCW: 104693453(XRN1)
FPG: 101913095(XRN1)
FCH: 102053827(XRN1)
CLV: 102097760(XRN1)
EGZ: 104127112(XRN1)
AAM: 106485908(XRN1)
ASN: 102380424(XRN1)
AMJ: 102558616(XRN1)
PSS: 102459789(XRN1)
CMY: 102936409(XRN1)
CPIC: 101931509(XRN1) 101947926
ACS: 100562142(xrn1)
PVT: 110078451(XRN1)
PBI: 103066866(XRN1)
GJA: 107112361(XRN1)
XLA: 108717067(xrn1.L) 108718136(xrn1.S)
XTR: 733797(xrn1)
NPR: 108786347(XRN1)
DRE: 394008(xrn1)
SANH: 107677707(xrn1) 107700493
CCAR: 109110725
IPU: 108280294(xrn1)
AMEX: 103022720(xrn1)
TRU: 101074214(xrn1)
LCO: 104929169(xrn1)
NCC: 104943158(xrn1) 104963513
MZE: 101463778(xrn1)
OLA: 101169885(xrn1)
XMA: 102228523(xrn1)
PRET: 103478843(xrn1)
NFU: 107395421(xrn1)
CSEM: 103396659(xrn1)
LCF: 108896664(xrn1)
HCQ: 109515519(xrn1)
BPEC: 110170407(xrn1)
ELS: 105018288(xrn1)
SFM: 108926832(xrn1)
LCM: 102350811(XRN1)
CMK: 103178358(xrn1)
CIN: 100175420(xrn1)
SPU: 578630
APLC: 110984281
SKO: 100369596
DME: Dmel_CG3291(pcm)
DSI: Dsimw501_GD27168(Dsim_GD27168)
MDE: 101894071
AAG: 5571065
AME: 409993(XRN1)
BIM: 100742741
BTER: 100649909
SOC: 105204713
AEC: 105154516
ACEP: 105621109
PBAR: 105430804
HST: 105190279
CFO: 105251517
LHU: 105674583
PGC: 109860415
TCA: 663618(XRN1)
DPA: 109540773
NVL: 108563534
BMOR: 101746591
PMAC: 106721332
PRAP: 110997731
PXY: 105383278
DNX: 107167875
ZNE: 110830323
FCD: 110842333
TUT: 107368142
CEL: CELE_Y39G8C.1(xrn-1)
CBR: CBG20837(Cbr-xrn-1)
CRG: 105340192
MYI: 110442937
OBI: 106881569
LAK: 106168392
SHX: MS3_08894
EPA: 110234286
ADF: 107331756
AQU: 100632707
CRE: CHLREDRAFT_95232(XRN1)
APRO: F751_4693
SCE: YGL173C(XRN1)
ERC: Ecym_8383
KMX: KLMA_40274(XRN1)
NCS: NCAS_0C04170(NCAS0C04170)
NDI: NDAI_0G03520(NDAI0G03520)
TPF: TPHA_0D00960(TPHA0D00960) TPHA_0H00510(TPHA0H00510)
TBL: TBLA_0G02750(TBLA0G02750)
TDL: TDEL_0F01070(TDEL0F01070)
KAF: KAFR_0C03080(KAFR0C03080)
CAL: CAALFM_C113420CA(KEM1)
CAUR: QG37_07407
SLB: AWJ20_379(XRN1)
NCR: NCU06678
NTE: NEUTE1DRAFT127448(NEUTE1DRAFT_127448)
MGR: MGG_12403
MAW: MAC_05995
MAJ: MAA_09154
CMT: CCM_03184
MBE: MBM_06945
ANI: AN8185.2
ANG: ANI_1_654084(An09g05290)
ABE: ARB_06879
TVE: TRV_05959
PTE: PTT_07733
SPO: SPAC17A5.14(exo2)
CNE: CNE03620
CNB: CNBE3620
ABP: AGABI1DRAFT114526(AGABI1DRAFT_114526)
ABV: AGABI2DRAFT184268(AGABI2DRAFT_184268)
MGL: MGL_4024
DDI: DDB_G0276137(xrn1)
DFA: DFA_04210 DFA_11745(xrn1)
PFA: PF11_0074
PYO: PY17X_0943100(PY03368)
PCB: PCHAS_090370(PC000586.02.0)
BBO: BBOV_II007140(18.m06591)
CPV: cgd6_2080
SMIN: v1.2.015746.t1(symbB.v1.2.015746.t1)
SPAR: SPRG_14369
TBR: Tb927.7.4900(Tb07.26A24.100)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chernyakov I, Whipple JM, Kotelawala L, Grayhack EJ, Phizicky EM
  Title
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
  Journal
Genes Dev 22:1369-80 (2008)
DOI:10.1101/gad.1654308
  Sequence
[sce:YGL173C]
Reference
  Authors
Mullen TE, Marzluff WF
  Title
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
  Journal
Genes Dev 22:50-65 (2008)
DOI:10.1101/gad.1622708
  Sequence
[hsa:54464]

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