KEGG   ORTHOLOGY: K12757Help
Entry
K12757                      KO                                     

Name
MYL12
Definition
myosin regulatory light chain 12
Pathway
ko04510  Focal adhesion
ko04530  Tight junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K12757  MYL12; myosin regulatory light chain 12
   04530 Tight junction
    K12757  MYL12; myosin regulatory light chain 12
  Cell motility
   04810 Regulation of actin cytoskeleton
    K12757  MYL12; myosin regulatory light chain 12
 Organismal Systems
  Immune system
   04611 Platelet activation
    K12757  MYL12; myosin regulatory light chain 12
   04670 Leukocyte transendothelial migration
    K12757  MYL12; myosin regulatory light chain 12
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     K12757  MYL12; myosin regulatory light chain 12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   K12757  MYL12; myosin regulatory light chain 12
BRITE hierarchy
Genes
HSA: 103910(MYL12B) 10627(MYL12A)
PTR: 455313(MYL12B) 455314(MYL12A)
PPS: 100972981 100977910(MYL12B) 100978696(MYL12A)
GGO: 101126168(MYL12B) 101127500 109028042
PON: 100172271(MYL12A) 100450310
NLE: 100585479(MYL12B) 100586474(MYL12A) 100599478 100600508
MCC: 694957(MYL12B) 695077(MYL12A)
MCF: 101926125 102124550(MYL12A)
CSAB: 103222701(MYL12B) 103222703(MYL12A)
RRO: 104654121(MYL12A) 104654122
RBB: 108533552 108533553(MYL12B)
CJC: 100386818 100409903(MYL12B) 100410505(MYL12B)
MMU: 67268(Myl12a) 67938(Myl12b)
RNO: 501203(Myl12a) 50685(Myl12b)
HGL: 101697884(Myl12b)
CFA: 480193(MYL12B) 607207(MYL12A)
PTG: 102971233(MYL12B) 102971525
BTA: 531505(MYL12A) 614055(MYL12B)
BOM: 102268971(MYL12B) 102269444
PHD: 102337985 102338581(MYL12B)
CHX: 102174891 102175348(MYL12B)
OAS: 100270714(MRCL3) 101105123
SSC: 414399(MRLC2) 733637
CFR: 102510666(MYL12B) 102511070
BACU: 103010250 103010734(MYL12B)
LVE: 103088639 103089268(MYL12B)
MYB: 102257812(MYL12B) 102258119
MYD: 102752077(MYL12B) 102752364
PALE: 102884859 102885115(MYL12B)
TMU: 101349753
MDO: 100012236 100012278(MYL12B)
OAA: 100092114
GGA: 107051991 396284(MYL12A) 770011(MYL12B)
CJO: 107310048
ACYG: 106034947 106034948(MYL12B)
GFR: 102038378(MYL12B)
CCW: 104687298
FPG: 101921847(MYL12B) 101922135
FCH: 102050744 102051137(MYL12B)
CLV: 102098580(MYL12B) 102098877
AMJ: 102560494 102569016(MYL12A)
CMY: 102937279(MYL12B) 102938771
CPIC: 101935947(MYL12B) 101936202
ACS: 100565496
PVT: 110079422
PBI: 103060959
GJA: 107118014
XLA: 108695600 380472(myl12b.L)
XTR: 448060(myl12b)
NPR: 108784895
DRE: 337084(myl12.2)
SASA: 106578694(MLRN) 106590146(MLRN)
LCM: 102346545
CMK: 103183460
DME: Dmel_CG3595(sqh)
DSI: Dsimw501_GD16204(Dsim_sqh)
DYA: Dyak_GE16476(Dyak_sqh)
MDE: 101897157
AAG: 5571226
AME: 550973 552638(GB18838)
BIM: 100745561
BTER: 100644439
SOC: 105196090
AEC: 105144770
ACEP: 105621380
PBAR: 105422709
HST: 105186929
CFO: 105255616
LHU: 105672816
PGC: 109853960
NVI: 100115576
TCA: 658477
DPA: 109542237
NVL: 108561709
PMAC: 106714529
API: 100163913
DNX: 107164171
ZNE: 110835883
CEL: CELE_C36E6.3(mlc-1) CELE_C36E6.5(mlc-2) CELE_C56G7.1(mlc-4)
CBR: CBG01858(Cbr-mlc-2.2) CBG01859(Cbr-mlc-1) CBG09860(Cbr-mlc-4)
HMG: 100204484
AQU: 100631435
CNE: CNE03510
CNB: CNBE3520
MRR: Moror_408
ABP: AGABI1DRAFT67432(AGABI1DRAFT_67432)
ABV: AGABI2DRAFT196727(AGABI2DRAFT_196727)
PYO: PY17X_1026800(PY05191)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Park I, Han C, Jin S, Lee B, Choi H, Kwon JT, Kim D, Kim J, Lifirsu E, Park WJ, Park ZY, Kim do H, Cho C
  Title
Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity.
  Journal
Biochem J 434:171-80 (2011)
DOI:10.1042/BJ20101473
Reference
  Authors
Suizu F, Ueda K, Iwasaki T, Murata-Hori M, Hosoya H
  Title
Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1b (RSK-2).
  Journal
J Biochem 128:435-40 (2000)
Reference
  Authors
Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H
  Title
Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells.
  Journal
Cell Struct Funct 26:677-83 (2001)
DOI:10.1247/csf.26.677
  Sequence

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