KEGG   ORTHOLOGY: K13241Help
Entry
K13241                      KO                                     

Name
NOS2
Definition
nitric-oxide synthase, inducible [EC:1.14.13.39]
Pathway
ko00220  Arginine biosynthesis
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04146  Peroxisome
ko04371  Apelin signaling pathway
ko04926  Relaxin signaling pathway
ko05132  Salmonella infection
ko05133  Pertussis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00017  Esophageal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00220 Arginine biosynthesis
    K13241  NOS2; nitric-oxide synthase, inducible
   00330 Arginine and proline metabolism
    K13241  NOS2; nitric-oxide synthase, inducible
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04066 HIF-1 signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04020 Calcium signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 Cellular Processes
  Transport and catabolism
   04146 Peroxisome
    K13241  NOS2; nitric-oxide synthase, inducible
 Organismal Systems
  Endocrine system
   04926 Relaxin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13241  NOS2; nitric-oxide synthase, inducible
   05222 Small cell lung cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  Infectious diseases
   05132 Salmonella infection
    K13241  NOS2; nitric-oxide synthase, inducible
   05133 Pertussis
    K13241  NOS2; nitric-oxide synthase, inducible
   05152 Tuberculosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05146 Amoebiasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05145 Toxoplasmosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05140 Leishmaniasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05142 Chagas disease (American trypanosomiasis)
    K13241  NOS2; nitric-oxide synthase, inducible
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13241  NOS2; nitric-oxide synthase, inducible
BRITE hierarchy
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4843(NOS2)
PTR: 455026(NOS2)
PPS: 100976546(NOS2)
GGO: 101134923(NOS2)
PON: 100436584(NOS2)
NLE: 100589003(NOS2)
MCC: 706921(NOS2)
MCF: 102121432(NOS2)
CSAB: 103242598 103242600(NOS2)
RRO: 104666105 104669357(NOS2)
RBB: 108539916 108539959(NOS2)
CJC: 100403192(NOS2)
SBQ: 101041016(NOS2)
MMU: 18126(Nos2)
RNO: 24599(Nos2) 497963
CGE: 100760062(Nos2)
NGI: 103724501(Nos2)
HGL: 101699617(Nos2)
CCAN: 109693015(Nos2)
OCU: 100008833(NOS2)
TUP: 102471872(NOS2)
CFA: 403822(NOS2)
AML: 100470060(NOS2)
UMR: 103667420(NOS2)
ORO: 101380967(NOS2)
FCA: 101087020(NOS2)
PTG: 102950049(NOS2)
AJU: 106984382(NOS2)
BTA: 282876(NOS2)
BOM: 102265893(NOS2)
BIU: 109574459(NOS2)
PHD: 102325091(NOS2)
CHX: 100860742(NOS2)
OAS: 443078(NOS2)
SSC: 396859(NOS2)
CFR: 102518523(NOS2)
CDK: 105088198(NOS2)
BACU: 103003780(NOS2)
LVE: 103074308(NOS2)
OOR: 101280638(NOS2)
ECB: 791246(NOS2)
EAI: 106844596(NOS2)
MYB: 102253125(NOS2)
MYD: 102768087(NOS2)
HAI: 109385084(NOS2)
RSS: 109447250(NOS2)
PALE: 102878456(NOS2)
LAV: 100676634(NOS2)
TMU: 101356579
MDO: 100024271(NOS2)
SHR: 100927789(NOS2)
OAA: 100075386(NOS2)
GGA: 395807(NOS2)
MGP: 692136(NOS2)
CJO: 107322733(NOS2)
APLA: 101804455(NOS2)
ACYG: 106043795(NOS2)
TGU: 100230954(NOS2)
GFR: 102044468(NOS2)
FAB: 101817488(NOS2)
PHI: 102108817(NOS2)
PMAJ: 107212812(NOS2)
CCW: 104690967(NOS2)
FPG: 101921726(NOS2)
FCH: 102048023(NOS2)
CLV: 102086291(NOS2)
EGZ: 104121908(NOS2)
AAM: 106498669(NOS2)
ASN: 102375419(NOS2)
AMJ: 106737013(NOS2)
PSS: 102446334(NOS2)
CMY: 102946684(NOS2)
CPIC: 101941684(NOS2)
ACS: 100561200(nos2)
PVT: 110088446(NOS2)
PBI: 103051066(NOS2)
GJA: 107119447(NOS2)
XLA: 108708038(nos2.L) 108708888(nos2.S)
XTR: 100494698(nos2)
NPR: 108801680(NOS2)
DRE: 404036(nos2a) 563654(nos2b)
IPU: 108277518(NOS2b2) 108278375(nos2)
SASA: 100136358(nos2)
ELS: 105013989(nos2) 109615805
SFM: 108932266(nos2)
LCM: 102354990(NOS2)
CMK: 103183299(nos2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7682706
  Authors
Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR
  Title
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
  Journal
Proc Natl Acad Sci U S A 90:3491-5 (1993)
DOI:10.1073/pnas.90.8.3491
  Sequence
[hsa:4843]

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