KEGG   ORTHOLOGY: K13241Help
Entry
K13241                      KO                                     

Name
NOS2
Definition
nitric-oxide synthase, inducible [EC:1.14.13.39]
Pathway
Arginine and proline metabolism
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
Disease
H00017  
Esophageal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00330 Arginine and proline metabolism
    K13241  NOS2; nitric-oxide synthase, inducible
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04020 Calcium signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 Cellular Processes
  Transport and catabolism
   04146 Peroxisome
    K13241  NOS2; nitric-oxide synthase, inducible
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13241  NOS2; nitric-oxide synthase, inducible
   05222 Small cell lung cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  Infectious diseases
   05132 Salmonella infection
    K13241  NOS2; nitric-oxide synthase, inducible
   05133 Pertussis
    K13241  NOS2; nitric-oxide synthase, inducible
   05152 Tuberculosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05146 Amoebiasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05145 Toxoplasmosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05140 Leishmaniasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05142 Chagas disease (American trypanosomiasis)
    K13241  NOS2; nitric-oxide synthase, inducible
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH dependent)
     K13241  NOS2; nitric-oxide synthase, inducible
BRITE hierarchy
Other DBs
Genes
HSA: 
4843(NOS2)
PTR: 
455026(NOS2)
PPS: 
GGO: 
PON: 
MCC: 
706921(NOS2)
MCF: 
102121432(NOS2)
MMU: 
18126(Nos2)
RNO: 
24599(Nos2)
CGE: 
HGL: 
101699617(Nos2)
TUP: 
102471872(NOS2)
CFA: 
403822(NOS2)
AML: 
FCA: 
101087020(NOS2)
BTA: 
282876(NOS2)
BOM: 
102265893(NOS2)
PHD: 
102325091(NOS2)
CHX: 
100860742(NOS2)
SSC: 
396859(NOS2)
CFR: 
102518523(NOS2)
ECB: 
791246(INOS)
MYB: 
102253125(NOS2)
MDO: 
100024271(NOS2)
SHR: 
100927789(NOS2)
OAA: 
100075386(NOS2)
GGA: 
395807(NOS2)
MGP: 
692136(INOS)
TGU: 
100230954(NOS2)
FAB: 
101817488(NOS2)
PHI: 
102108817(NOS2)
APLA: 
101804455(NOS2)
FPG: 
101921726(NOS2)
FCH: 
102048023(NOS2)
CLV: 
102086291(NOS2)
ASN: 
102375419(NOS2)
PSS: 
102446334(NOS2)
ACS: 
XTR: 
100494698(nos2)
DRE: 
404036(nos2a) 563654(nos2b)
LCM: 
102354990(NOS2)
ZTR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Alderton WK, Cooper CE, Knowles RG
  Title
Nitric oxide synthases: structure, function and inhibition.
  Journal
Biochem J 357:593-615 (2001)
Reference
PMID:9544420
  Authors
Geller DA, Billiar TR
  Title
Molecular biology of nitric oxide synthases.
  Journal
Cancer Metastasis Rev 17:7-23 (1998)

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