KEGG   ORTHOLOGY: K13242Help
Entry
K13242                      KO                                     

Name
NOS3
Definition
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Pathway
Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Apelin signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Fluid shear stress and atherosclerosis
Disease
H01529  
Avascular necrosis of femoral head
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04371 Apelin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP - PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 Organismal Systems
  Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04926 Relaxin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial
BRITE hierarchy
Other DBs
Genes
HSA: 
4846(NOS3)
PTR: 
463893(NOS3)
PPS: 
100974638(NOS3)
GGO: 
101128007(NOS3)
PON: 
100447953(NOS3)
NLE: 
MCC: 
714231(NOS3)
MCF: 
102143504(NOS3)
CSAB: 
103227233(NOS3)
RRO: 
104675393(NOS3)
RBB: 
108532525(NOS3)
CJC: 
100405019(NOS3)
SBQ: 
101034220(NOS3)
MMU: 
18127(Nos3)
RNO: 
24600(Nos3)
CGE: 
100769961(Nos3)
NGI: 
103745303(Nos3)
HGL: 
101711110(Nos3)
CCAN: 
109694442(Nos3)
OCU: 
100009498(NOS3)
TUP: 
102495986(NOS3)
CFA: 
403784(NOS3)
AML: 
100483990(NOS3)
UMR: 
103660958(NOS3)
ORO: 
101382350(NOS3)
FCA: 
101096463(NOS3)
PTG: 
102967516(NOS3)
AJU: 
106969560(NOS3)
BTA: 
287024(NOS3)
BOM: 
102267556(NOS3)
BIU: 
109557793(NOS3)
PHD: 
102327398(NOS3)
CHX: 
102185338(NOS3)
OAS: 
443073(NOS3) 443077(NOS3)
SSC: 
397557(NOS3)
CFR: 
102524296(NOS3)
CDK: 
105105831(NOS3)
BACU: 
103017861(NOS3)
LVE: 
103087259(NOS3)
ECB: 
100063339(NOS3)
EPZ: 
103540937(NOS3)
EAI: 
106823361(NOS3)
MYB: 
102256555(NOS3)
MYD: 
102764374(NOS3)
HAI: 
109389680(NOS3)
RSS: 
109435172(NOS3)
PALE: 
102879945(NOS3)
LAV: 
100668912(NOS3)
TMU: 
MDO: 
100018035(NOS3)
SHR: 
100913437(NOS3)
OAA: 
100091599(NOS3)
CJO: 
107308662(NOS3)
FAB: 
PHI: 
102112141(NOS3)
FPG: 
101918492(NOS3)
FCH: 
102057360(NOS3)
CLV: 
AAM: 
ASN: 
102381196(NOS3)
AMJ: 
102575253(NOS3)
CMY: 
CPIC: 
101952927(NOS3)
ACS: 
100557597(nos3)
PVT: 
110082598(NOS3)
PBI: 
GJA: 
107118610(NOS3)
XLA: 
108704634(nos3.L)
XTR: 
100486016(nos3)
NPR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1378832
  Authors
Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD
  Title
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.
  Journal
J Biol Chem 267:14519-22 (1992)
  Sequence
[hsa:4846]

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