KEGG   ORTHOLOGY: K13242Help
Entry
K13242                      KO                                     

Name
NOS3
Definition
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Pathway
Arginine biosynthesis
Arginine and proline metabolism
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathway
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP - PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 Organismal Systems
  Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 Human Diseases
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial
BRITE hierarchy
Other DBs
Genes
HSA: 
4846(NOS3)
PTR: 
463893(NOS3)
PPS: 
100974638(NOS3)
GGO: 
101128007(NOS3)
PON: 
100447953(NOS3)
NLE: 
MCC: 
714231(NOS3)
MCF: 
102143504(NOS3)
RRO: 
104675393(NOS3)
CJC: 
100405019(NOS3)
MMU: 
18127(Nos3)
RNO: 
24600(Nos3)
CGE: 
100769961(Nos3)
NGI: 
103745303(Nos3)
HGL: 
101711110(Nos3)
OCU: 
100009498(NOS3)
TUP: 
102495986(NOS3)
CFA: 
403784(NOS3)
AML: 
100483990(NOS3)
UMR: 
103660958(NOS3)
FCA: 
101096463(NOS3)
PTG: 
102967516(NOS3)
BTA: 
287024(NOS3)
BOM: 
102267556(NOS3)
PHD: 
102327398(NOS3)
CHX: 
102185338(NOS3)
OAS: 
443073(NOS3) 443077(NOS3)
SSC: 
397557(NOS3)
CFR: 
102524296(NOS3)
BACU: 
103017861(NOS3)
LVE: 
103087259(NOS3)
ECB: 
100063339(NOS3)
MYB: 
102256555(NOS3)
MYD: 
102764374(NOS3)
PALE: 
102879945(NOS3)
MDO: 
100018035(NOS3)
SHR: 
100913437(NOS3)
OAA: 
100091599(NOS3)
FAB: 
PHI: 
102112141(NOS3)
FPG: 
101918492(NOS3)
FCH: 
102057360(NOS3)
CLV: 
102084237(NOS3)
ASN: 
102381196(NOS3)
AMJ: 
102575253(NOS3)
CMY: 
ACS: 
100557597(nos3)
PBI: 
XTR: 
100486016(nos3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Alderton WK, Cooper CE, Knowles RG
  Title
Nitric oxide synthases: structure, function and inhibition.
  Journal
Biochem J 357:593-615 (2001)
Reference
PMID:9544420
  Authors
Geller DA, Billiar TR
  Title
Molecular biology of nitric oxide synthases.
  Journal
Cancer Metastasis Rev 17:7-23 (1998)

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