KEGG ORTHOLOGY: K13375

ORTHOLOGY: K13375

Entry

K13375 KO

Name

TGFB1

Definition

transforming growth factor beta-1

Pathway

ko04010	MAPK signaling pathway
ko04060	Cytokine-cytokine receptor interaction
ko04110	Cell cycle
ko04144	Endocytosis
ko04350	TGF-beta signaling pathway
ko04380	Osteoclast differentiation
ko04390	Hippo signaling pathway
ko04672	Intestinal immune network for IgA production
ko05140	Leishmaniasis
ko05142	Chagas disease (American trypanosomiasis)
ko05144	Malaria
ko05145	Toxoplasmosis
ko05146	Amoebiasis
ko05152	Tuberculosis
ko05161	Hepatitis B
ko05166	HTLV-I infection
ko05200	Pathways in cancer
ko05205	Proteoglycans in cancer
ko05210	Colorectal cancer
ko05211	Renal cell carcinoma
ko05212	Pancreatic cancer
ko05220	Chronic myeloid leukemia
ko05323	Rheumatoid arthritis
ko05410	Hypertrophic cardiomyopathy (HCM)
ko05414	Dilated cardiomyopathy

Disease

H00083	Allograft rejection
H00084	Graft-versus-host disease
H00434	Camurati-Engelmann disease

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04350 TGF-beta signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04390 Hippo signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13375  TGFB1; transforming growth factor beta-1
Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K13375  TGFB1; transforming growth factor beta-1
  Cell growth and death
   04110 Cell cycle
    K13375  TGFB1; transforming growth factor beta-1
Organismal Systems
  Immune system
   04672 Intestinal immune network for IgA production
    K13375  TGFB1; transforming growth factor beta-1
  Development
   04380 Osteoclast differentiation
    K13375  TGFB1; transforming growth factor beta-1
Human Diseases
  Cancers
   05200 Pathways in cancer
    K13375  TGFB1; transforming growth factor beta-1
   05205 Proteoglycans in cancer
    K13375  TGFB1; transforming growth factor beta-1
   05210 Colorectal cancer
    K13375  TGFB1; transforming growth factor beta-1
   05212 Pancreatic cancer
    K13375  TGFB1; transforming growth factor beta-1
   05220 Chronic myeloid leukemia
    K13375  TGFB1; transforming growth factor beta-1
   05211 Renal cell carcinoma
    K13375  TGFB1; transforming growth factor beta-1
  Immune diseases
   05323 Rheumatoid arthritis
    K13375  TGFB1; transforming growth factor beta-1
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13375  TGFB1; transforming growth factor beta-1
   05414 Dilated cardiomyopathy (DCM)
    K13375  TGFB1; transforming growth factor beta-1
  Infectious diseases
   05152 Tuberculosis
    K13375  TGFB1; transforming growth factor beta-1
   05166 HTLV-I infection
    K13375  TGFB1; transforming growth factor beta-1
   05161 Hepatitis B
    K13375  TGFB1; transforming growth factor beta-1
   05146 Amoebiasis
    K13375  TGFB1; transforming growth factor beta-1
   05144 Malaria
    K13375  TGFB1; transforming growth factor beta-1
   05145 Toxoplasmosis
    K13375  TGFB1; transforming growth factor beta-1
   05140 Leishmaniasis
    K13375  TGFB1; transforming growth factor beta-1
   05142 Chagas disease (American trypanosomiasis)
    K13375  TGFB1; transforming growth factor beta-1
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Others
   K13375  TGFB1; transforming growth factor beta-1
Cytokines [BR:ko04052]
TGF-beta family
  TGF-beta subfamily
   K13375  TGFB1; transforming growth factor beta-1
Cell adhesion molecules and their ligands [BR:ko04516]
2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K13375 TGFB1; transforming growth factor beta-1
   alpha V beta 1
    ITGB1; integrin beta 1
     K13375 TGFB1; transforming growth factor beta-1
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K13375 TGFB1; transforming growth factor beta-1
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K13375  TGFB1; transforming growth factor beta-1
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K13375 TGFB1; transforming growth factor beta-1
6. Sialomucin Family
  GLG1, ESL1; golgi apparatus protein 1
   K13375 TGFB1; transforming growth factor beta-1
Heparan sulfate/heparin binding proteins [BR:ko00536]
Growth factors/receptors
  K13375  TGFB1; transforming growth factor beta-1

Genes

HSA:	7040(TGFB1)
PTR:	456060(TGFB1)
PPS:	100980947(TGFB1)
GGO:	101124474(TGFB1)
PON:	100459982(TGFB1)
MCC:	574135(TGFB1)
MMU:	21803(Tgfb1)
RNO:	59086(Tgfb1)
CFA:	403998(TGFB1)
FCA:	768263(TGFB1)
BTA:	282089(TGFB1)
SSC:	397078(TGFB1)
ECB:	100033900(TGFB1)
MDO:	100019183
SHR:	100932607(TGFB1)
ACS:	100553920
XLA:	397778(tgfb1)
XTR:	100498430
DRE:	359834(tgfb1a)

» show all

Reference

PMID:18000526

Authors

Schmierer B, Hill CS

Title

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.

Journal

Nat Rev Mol Cell Biol 8:970-82 (2007)

Reference

PMID:9759503

Authors

Massague J.

Title

TGF-beta signal transduction.

Journal

Annu Rev Biochem 67:753-91 (1998)

Reference

PMID:19050695

Authors

Chen YG

Title

Endocytic regulation of TGF-beta signaling.

Journal

Cell Res 19:58-70 (2009)

All links

Ontology (8)   
   KEGG BRITE (8)   
Pathway (50)   
   KEGG PATHWAY (50)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (1)   
   KEGG DRUG (1)   
Gene (26)   
   KEGG GENES (19)   
   KEGG DGENES (1)   
   KEGG EGENES (6)   
Protein sequence (11)   
   UniProt (11)   
Literature (3)   
   PubMed (3)   
All databases (102)   

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