KEGG   ORTHOLOGY: K13375Help
Entry
K13375                      KO                                     

Name
TGFB1
Definition
transforming growth factor beta-1
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04659  Th17 cell differentiation
ko04672  Intestinal immune network for IgA production
ko04926  Relaxin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05144  Malaria
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05321  Inflammatory bowel disease (IBD)
ko05323  Rheumatoid arthritis
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05414  Dilated cardiomyopathy (DCM)
Module
M00680  TGF-beta signaling
Disease
H00083  Allograft rejection
H00084  Graft-versus-host disease
H00434  Camurati-Engelmann disease
H01593  Osteoporosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04350 TGF-beta signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04390 Hippo signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04068 FoxO signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13375  TGFB1; transforming growth factor beta-1
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K13375  TGFB1; transforming growth factor beta-1
   04218 Cellular senescence
    K13375  TGFB1; transforming growth factor beta-1
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K13375  TGFB1; transforming growth factor beta-1
   04672 Intestinal immune network for IgA production
    K13375  TGFB1; transforming growth factor beta-1
  Endocrine system
   04926 Relaxin signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
  Development
   04380 Osteoclast differentiation
    K13375  TGFB1; transforming growth factor beta-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13375  TGFB1; transforming growth factor beta-1
   05205 Proteoglycans in cancer
    K13375  TGFB1; transforming growth factor beta-1
   05210 Colorectal cancer
    K13375  TGFB1; transforming growth factor beta-1
   05212 Pancreatic cancer
    K13375  TGFB1; transforming growth factor beta-1
   05225 Hepatocellular carcinoma
    K13375  TGFB1; transforming growth factor beta-1
   05226 Gastric cancer
    K13375  TGFB1; transforming growth factor beta-1
   05220 Chronic myeloid leukemia
    K13375  TGFB1; transforming growth factor beta-1
   05211 Renal cell carcinoma
    K13375  TGFB1; transforming growth factor beta-1
  Immune diseases
   05323 Rheumatoid arthritis
    K13375  TGFB1; transforming growth factor beta-1
   05321 Inflammatiory bowel disease (IBD)
    K13375  TGFB1; transforming growth factor beta-1
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13375  TGFB1; transforming growth factor beta-1
   05414 Dilated cardiomyopathy (DCM)
    K13375  TGFB1; transforming growth factor beta-1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K13375  TGFB1; transforming growth factor beta-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13375  TGFB1; transforming growth factor beta-1
  Infectious diseases
   05152 Tuberculosis
    K13375  TGFB1; transforming growth factor beta-1
   05166 HTLV-I infection
    K13375  TGFB1; transforming growth factor beta-1
   05161 Hepatitis B
    K13375  TGFB1; transforming growth factor beta-1
   05146 Amoebiasis
    K13375  TGFB1; transforming growth factor beta-1
   05144 Malaria
    K13375  TGFB1; transforming growth factor beta-1
   05145 Toxoplasmosis
    K13375  TGFB1; transforming growth factor beta-1
   05140 Leishmaniasis
    K13375  TGFB1; transforming growth factor beta-1
   05142 Chagas disease (American trypanosomiasis)
    K13375  TGFB1; transforming growth factor beta-1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K13375  TGFB1; transforming growth factor beta-1
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Others
   K13375  TGFB1; transforming growth factor beta-1
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   K13375  TGFB1; transforming growth factor beta-1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K13375  TGFB1; transforming growth factor beta-1
BRITE hierarchy
Genes
HSA: 7040(TGFB1)
PTR: 456060(TGFB1)
PPS: 100980947(TGFB1)
GGO: 101124474(TGFB1)
PON: 100459982(TGFB1)
NLE: 100581386(TGFB1)
MCC: 106992315(TGFB1) 574135(TGFB1)
MCF: 102129546(TGFB1)
CSAB: 103234729(TGFB1)
RRO: 104676086(TGFB1)
RBB: 108536158(TGFB1)
CJC: 100401979(TGFB1)
SBQ: 101047980(TGFB1)
MMU: 21803(Tgfb1)
RNO: 59086(Tgfb1)
CGE: 100773359(Tgfb1)
NGI: 103751514(Tgfb1)
HGL: 101704230(Tgfb1)
CCAN: 109685632(Tgfb1)
TUP: 102488524(TGFB1)
CFA: 403998(TGFB1)
AML: 100470703(TGFB1)
UMR: 103677394
ORO: 101385166(TGFB1)
FCA: 768263(TGFB1)
PTG: 102951285(TGFB1)
AJU: 106987682(TGFB1)
BTA: 282089(TGFB1)
BOM: 102283357(TGFB1)
BIU: 109572866(TGFB1)
PHD: 102317860(TGFB1)
CHX: 102191364(TGFB1)
OAS: 443417(TGFB1)
SSC: 397078(TGFB1)
CFR: 102509937(TGFB1)
CDK: 105093367(TGFB1)
BACU: 103002687(TGFB1)
LVE: 103075846(TGFB1)
OOR: 101286197(TGFB1)
ECB: 100033900(TGFB1)
EPZ: 103562543(TGFB1)
EAI: 106843812(TGFB1)
MYB: 102262083(TGFB1)
MYD: 102752983(TGFB1)
HAI: 109376590(TGFB1)
RSS: 109458052(TGFB1)
PALE: 102884154(TGFB1)
LAV: 100667634(TGFB1)
TMU: 101342543
MDO: 100019183(TGFB1)
SHR: 100932607(TGFB1)
GGA: 100873157(TGFB1)
CJO: 107307103(TGFB1)
PHI: 102112781(TGFB1)
PMAJ: 107198990(TGFB1)
ASN: 102369002(TGFB1)
AMJ: 102567067(TGFB1)
CPIC: 101937891(TGFB1)
ACS: 100553920(tgfb1)
PVT: 110088538(TGFB1)
PBI: 103064413(TGFB1)
GJA: 107123911(TGFB1)
XLA: 108700276(tgfb1.S) 397778(tgfb1.L)
XTR: 100498430(tgfb1)
NPR: 108800768
DRE: 359834(tgfb1a) 563884(tgfb1b)
IPU: 108279384(tgfb1) 108280750(tgfb1)
AMEX: 103024607 103033069(tgfb1)
TRU: 101074275(tgf-beta1)
NCC: 104950840
MZE: 101473892
OLA: 101157631
XMA: 102216881
PRET: 103475119
NFU: 107379821
CSEM: 103377845
LCF: 108876160
HCQ: 109510758
BPEC: 110163549
SASA: 100136559(TGFB1) 106563563(TGF-beta) 106613337
LCM: 102364242(TGFB1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3470709
  Authors
Derynck R, Rhee L, Chen EY, Van Tilburg A
  Title
Intron-exon structure of the human transforming growth factor-beta precursor gene.
  Journal
Nucleic Acids Res 15:3188-9 (1987)
DOI:10.1093/nar/15.7.3188
  Sequence
[hsa:7040]

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