KEGG   ORTHOLOGY: K13376Help
Entry
K13376                      KO                                     

Name
TGFB2
Definition
transforming growth factor beta-2
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
Disease
H00083  
Allograft rejection
H00084  
Graft-versus-host disease
H00800  
Loeys-Dietz syndrome (LDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04350 TGF-beta signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04390 Hippo signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04068 FoxO signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13376  TGFB2; transforming growth factor beta-2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K13376  TGFB2; transforming growth factor beta-2
  Cell growth and death
   04110 Cell cycle
    K13376  TGFB2; transforming growth factor beta-2
 Organismal Systems
  Development
   04380 Osteoclast differentiation
    K13376  TGFB2; transforming growth factor beta-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05206 MicroRNAs in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05205 Proteoglycans in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05210 Colorectal cancer
    K13376  TGFB2; transforming growth factor beta-2
   05212 Pancreatic cancer
    K13376  TGFB2; transforming growth factor beta-2
   05220 Chronic myeloid leukemia
    K13376  TGFB2; transforming growth factor beta-2
   05211 Renal cell carcinoma
    K13376  TGFB2; transforming growth factor beta-2
  Immune diseases
   05323 Rheumatoid arthritis
    K13376  TGFB2; transforming growth factor beta-2
   05321 Inflammatiory bowel disease (IBD)
    K13376  TGFB2; transforming growth factor beta-2
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13376  TGFB2; transforming growth factor beta-2
   05414 Dilated cardiomyopathy (DCM)
    K13376  TGFB2; transforming growth factor beta-2
  Infectious diseases
   05152 Tuberculosis
    K13376  TGFB2; transforming growth factor beta-2
   05166 HTLV-I infection
    K13376  TGFB2; transforming growth factor beta-2
   05161 Hepatitis B
    K13376  TGFB2; transforming growth factor beta-2
   05146 Amoebiasis
    K13376  TGFB2; transforming growth factor beta-2
   05144 Malaria
    K13376  TGFB2; transforming growth factor beta-2
   05145 Toxoplasmosis
    K13376  TGFB2; transforming growth factor beta-2
   05140 Leishmaniasis
    K13376  TGFB2; transforming growth factor beta-2
   05142 Chagas disease (American trypanosomiasis)
    K13376  TGFB2; transforming growth factor beta-2
Cytokines [BR:ko04052]
 TGF-beta family
  TGF-beta subfamily
   K13376  TGFB2; transforming growth factor beta-2
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K13376 TGFB2; transforming growth factor beta-2
   alpha V beta 1
    ITGB1; integrin beta 1
     K13376 TGFB2; transforming growth factor beta-2
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K13376 TGFB2; transforming growth factor beta-2
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K13376 TGFB2; transforming growth factor beta-2
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K13376 TGFB2; transforming growth factor beta-2
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Growth factors/receptors
  K13376  TGFB2; transforming growth factor beta-2
BRITE hierarchy
Genes
HSA: 
7042(TGFB2)
PTR: 
457742(TGFB2)
PPS: 
100985755(TGFB2)
GGO: 
101125504(TGFB2)
PON: 
100461291(TGFB2)
MCC: 
707540(TGFB2)
MCF: 
MMU: 
21808(Tgfb2)
RNO: 
81809(Tgfb2)
CGE: 
100774918(Tgfb2)
HGL: 
101707457(Tgfb2)
TUP: 
102500482(TGFB2)
CFA: 
488596(TGFB2)
AML: 
FCA: 
101093414(TGFB2)
PTG: 
102951894(TGFB2)
BTA: 
534069(TGFB2)
BOM: 
102283491(TGFB2)
PHD: 
102317456(TGFB2)
CHX: 
SSC: 
397084(TGFB2)
CFR: 
102505811(TGFB2)
ECB: 
100050377(TGFB2)
MYB: 
102250887(TGFB2)
MYD: 
102755920(TGFB2)
PALE: 
102881295(TGFB2)
MDO: 
100017548(TGFB2)
SHR: 
100914910(TGFB2)
OAA: 
100080176(TGFB2)
GGA: 
421352(TGFB2)
MGP: 
TGU: 
100231617(TGFB2)
FAB: 
101814341(TGFB2)
PHI: 
102114598(TGFB2)
APLA: 
FPG: 
101917357(TGFB2)
FCH: 
102047778(TGFB2)
CLV: 
102085196(TGFB2)
ASN: 
102382227(TGFB2)
PSS: 
102452874(TGFB2)
CMY: 
102946116(TGFB2)
ACS: 
XLA: 
373801(tgfb2)
XTR: 
100489680(tgfb2)
DRE: 
369194(tgfb2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CIN: 
778780(tgfbeta2)
SPU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Chen YG
  Title
Endocytic regulation of TGF-beta signaling.
  Journal
Cell Res 19:58-70 (2009)

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