KEGG   ORTHOLOGY: K13377Help
Entry
K13377                      KO                                     

Name
TGFB3
Definition
transforming growth factor beta-3
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Cellular senescence
TGF-beta signaling pathway
Hippo signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Hepatocellular carcinoma
Gastric cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy (DCM)
Module
M00680  
TGF-beta signaling
Disease
H00083  
Allograft rejection
H00084  
Graft-versus-host disease
H00293  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
H00431  
Ossification of the posterior longitudinal ligament of spine (OPLL)
H00516  
Cleft lip and/or cleft palate
H00800  
Loeys-Dietz syndrome (LDS)
H01385  
Rienhoff syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04350 TGF-beta signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04390 Hippo signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04068 FoxO signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13377  TGFB3; transforming growth factor beta-3
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K13377  TGFB3; transforming growth factor beta-3
   04218 Cellular senescence
    K13377  TGFB3; transforming growth factor beta-3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13377  TGFB3; transforming growth factor beta-3
   05210 Colorectal cancer
    K13377  TGFB3; transforming growth factor beta-3
   05212 Pancreatic cancer
    K13377  TGFB3; transforming growth factor beta-3
   05225 Hepatocellular carcinoma
    K13377  TGFB3; transforming growth factor beta-3
   05226 Gastric cancer
    K13377  TGFB3; transforming growth factor beta-3
   05220 Chronic myeloid leukemia
    K13377  TGFB3; transforming growth factor beta-3
   05211 Renal cell carcinoma
    K13377  TGFB3; transforming growth factor beta-3
  Immune diseases
   05323 Rheumatoid arthritis
    K13377  TGFB3; transforming growth factor beta-3
   05321 Inflammatiory bowel disease (IBD)
    K13377  TGFB3; transforming growth factor beta-3
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13377  TGFB3; transforming growth factor beta-3
   05414 Dilated cardiomyopathy (DCM)
    K13377  TGFB3; transforming growth factor beta-3
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13377  TGFB3; transforming growth factor beta-3
  Infectious diseases
   05152 Tuberculosis
    K13377  TGFB3; transforming growth factor beta-3
   05166 HTLV-I infection
    K13377  TGFB3; transforming growth factor beta-3
   05161 Hepatitis B
    K13377  TGFB3; transforming growth factor beta-3
   05146 Amoebiasis
    K13377  TGFB3; transforming growth factor beta-3
   05144 Malaria
    K13377  TGFB3; transforming growth factor beta-3
   05145 Toxoplasmosis
    K13377  TGFB3; transforming growth factor beta-3
   05140 Leishmaniasis
    K13377  TGFB3; transforming growth factor beta-3
   05142 Chagas disease (American trypanosomiasis)
    K13377  TGFB3; transforming growth factor beta-3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K13377  TGFB3; transforming growth factor beta-3
Cytokines [BR:ko04052]
 TGF-beta family
  TGF-beta subfamily
   K13377  TGFB3; transforming growth factor beta-3
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K13377 TGFB3; transforming growth factor beta-3
   alpha V beta 1
    ITGB1; integrin beta 1
     K13377 TGFB3; transforming growth factor beta-3
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K13377 TGFB3; transforming growth factor beta-3
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K13377 TGFB3; transforming growth factor beta-3
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K13377 TGFB3; transforming growth factor beta-3
BRITE hierarchy
Genes
HSA: 
7043(TGFB3)
PTR: 
453054(TGFB3)
PPS: 
100990987(TGFB3)
GGO: 
101133741(TGFB3)
PON: 
100433208(TGFB3)
NLE: 
100591391(TGFB3)
MCC: 
703239(TGFB3)
MCF: 
102119907(TGFB3)
CSAB: 
103229367(TGFB3)
RRO: 
104677599(TGFB3)
RBB: 
108534939(TGFB3)
CJC: 
100392463(TGFB3)
SBQ: 
101048819(TGFB3)
MMU: 
21809(Tgfb3)
RNO: 
25717(Tgfb3)
CGE: 
100756831(Tgfb3)
NGI: 
103739777(Tgfb3)
HGL: 
101712904(Tgfb3)
CCAN: 
109686152(Tgfb3)
OCU: 
100358982(TGFB3)
TUP: 
102497029(TGFB3)
CFA: 
490796(TGFB3)
AML: 
100475861(TGFB3)
UMR: 
103670922(TGFB3)
ORO: 
101364584(TGFB3)
FCA: 
101098469(TGFB3)
PTG: 
102949760(TGFB3)
AJU: 
106974351(TGFB3)
BTA: 
538957(TGFB3)
BOM: 
102265567(TGFB3)
BIU: 
109565371(TGFB3)
PHD: 
102342990(TGFB3)
CHX: 
102189962(TGFB3)
OAS: 
554323(TGFB3)
SSC: 
397400(TGFB3)
CFR: 
102517948(TGFB3)
CDK: 
105086078(TGFB3)
BACU: 
103001029(TGFB3)
LVE: 
103086562(TGFB3)
ECB: 
100051765(TGFB3)
EPZ: 
103555506(TGFB3)
EAI: 
106830938(TGFB3)
MYB: 
102249502(TGFB3)
MYD: 
102767291(TGFB3)
HAI: 
109381619(TGFB3)
RSS: 
109448352(TGFB3)
PALE: 
102893304(TGFB3)
LAV: 
100653832(TGFB3)
TMU: 
MDO: 
100017937(TGFB3)
SHR: 
100929617(TGFB3)
OAA: 
100074840(TGFB3)
GGA: 
396438(TGFB3)
MGP: 
100544554(TGFB3)
CJO: 
107315120(TGFB3)
APLA: 
101802287(TGFB3)
ACYG: 
106038869(TGFB3)
TGU: 
100232487(TGFB3)
GFR: 
102037028(TGFB3)
FAB: 
101809258(TGFB3)
PHI: 
102102248(TGFB3)
PMAJ: 
107205526(TGFB3)
CCW: 
104685280(TGFB3)
FPG: 
101912650(TGFB3)
FCH: 
102055453(TGFB3)
CLV: 
102088125(TGFB3)
EGZ: 
104133279(TGFB3)
AAM: 
106482877(TGFB3)
ASN: 
102384560(TGFB3)
AMJ: 
102563668(TGFB3)
PSS: 
102456369(TGFB3)
CMY: 
102929710(TGFB3)
CPIC: 
101941121(TGFB3)
ACS: 
100551709(tgfb3)
PVT: 
110079121(TGFB3)
PBI: 
103061116(TGFB3)
GJA: 
107116455(TGFB3)
DRE: 
369195(tgfb3)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108270130(tgfb3)
AMEX: 
103032923(tgfb3)
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
109507757(tgfb3)
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102358543(TGFB3)
CMK: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
DOI:10.1038/nrm2297
Reference
  Authors
Chen YG
  Title
Endocytic regulation of TGF-beta signaling.
  Journal
Cell Res 19:58-70 (2009)
DOI:10.1038/cr.2008.315
Reference
  Authors
Bocharov EV, Korzhnev DM, Blommers MJ, Arvinte T, Orekhov VY, Billeter M, Arseniev AS
  Title
Dynamics-modulated biological activity of transforming growth factor beta3.
  Journal
J Biol Chem 277:46273-9 (2002)
DOI:10.1074/jbc.M206274200
  Sequence
[hsa:7043]
Reference
PMID:3208746
  Authors
Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ, et al.
  Title
A new type of transforming growth factor-beta, TGF-beta 3.
  Journal
EMBO J 7:3737-43 (1988)
  Sequence
[hsa:7043]

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