KEGG   ORTHOLOGY: K13377Help
Entry
K13377                      KO                                     

Name
TGFB3
Definition
transforming growth factor beta-3
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
Module
M00680  
TGF-beta signaling
Disease
H00083  
Allograft rejection
H00084  
Graft-versus-host disease
H00293  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
H00431  
Ossification of the posterior longitudinal ligament of spine (OPLL)
H00516  
Isolated orofacial clefts
H01385  
Rienhoff syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04350 TGF-beta signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04390 Hippo signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
   04068 FoxO signaling pathway
    K13377  TGFB3; transforming growth factor beta-3
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13377  TGFB3; transforming growth factor beta-3
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K13377  TGFB3; transforming growth factor beta-3
  Cell growth and death
   04110 Cell cycle
    K13377  TGFB3; transforming growth factor beta-3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13377  TGFB3; transforming growth factor beta-3
   05210 Colorectal cancer
    K13377  TGFB3; transforming growth factor beta-3
   05212 Pancreatic cancer
    K13377  TGFB3; transforming growth factor beta-3
   05220 Chronic myeloid leukemia
    K13377  TGFB3; transforming growth factor beta-3
   05211 Renal cell carcinoma
    K13377  TGFB3; transforming growth factor beta-3
  Immune diseases
   05323 Rheumatoid arthritis
    K13377  TGFB3; transforming growth factor beta-3
   05321 Inflammatiory bowel disease (IBD)
    K13377  TGFB3; transforming growth factor beta-3
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13377  TGFB3; transforming growth factor beta-3
   05414 Dilated cardiomyopathy (DCM)
    K13377  TGFB3; transforming growth factor beta-3
  Infectious diseases
   05152 Tuberculosis
    K13377  TGFB3; transforming growth factor beta-3
   05166 HTLV-I infection
    K13377  TGFB3; transforming growth factor beta-3
   05161 Hepatitis B
    K13377  TGFB3; transforming growth factor beta-3
   05146 Amoebiasis
    K13377  TGFB3; transforming growth factor beta-3
   05144 Malaria
    K13377  TGFB3; transforming growth factor beta-3
   05145 Toxoplasmosis
    K13377  TGFB3; transforming growth factor beta-3
   05140 Leishmaniasis
    K13377  TGFB3; transforming growth factor beta-3
   05142 Chagas disease (American trypanosomiasis)
    K13377  TGFB3; transforming growth factor beta-3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K13377  TGFB3; transforming growth factor beta-3
Cytokines [BR:ko04052]
 TGF-beta family
  TGF-beta subfamily
   K13377  TGFB3; transforming growth factor beta-3
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K13377 TGFB3; transforming growth factor beta-3
   alpha V beta 1
    ITGB1; integrin beta 1
     K13377 TGFB3; transforming growth factor beta-3
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K13377 TGFB3; transforming growth factor beta-3
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K13377 TGFB3; transforming growth factor beta-3
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K13377 TGFB3; transforming growth factor beta-3
BRITE hierarchy
Genes
HSA: 
7043(TGFB3)
PTR: 
453054(TGFB3)
PPS: 
100990987(TGFB3)
GGO: 
101133741(TGFB3)
PON: 
100433208(TGFB3)
NLE: 
100591391(TGFB3)
MCC: 
703239(TGFB3)
MCF: 
102119907(TGFB3)
CJC: 
100392463(TGFB3)
MMU: 
21809(Tgfb3)
RNO: 
25717(Tgfb3)
CGE: 
100756831(Tgfb3)
NGI: 
103739777(Tgfb3)
HGL: 
101712904(Tgfb3)
OCU: 
100358982(TGFB3)
TUP: 
102497029(TGFB3)
CFA: 
490796(TGFB3)
AML: 
100475861(TGFB3)
UMR: 
103670922(TGFB3)
FCA: 
101098469(TGFB3)
PTG: 
102949760(TGFB3)
BTA: 
538957(TGFB3)
BOM: 
102265567(TGFB3)
PHD: 
102342990(TGFB3)
CHX: 
102189962(TGFB3)
OAS: 
554323(TGFB3)
SSC: 
397400(TGFB3)
CFR: 
102517948(TGFB3)
BACU: 
103001029(TGFB3)
LVE: 
103086562(TGFB3)
ECB: 
100051765(TGFB3)
MYB: 
102249502(TGFB3)
MYD: 
102767291(TGFB3)
PALE: 
102893304(TGFB3)
MDO: 
100017937(TGFB3)
SHR: 
100929617(TGFB3)
OAA: 
100074840(TGFB3)
GGA: 
396438(TGFB3)
MGP: 
100544554(TGFB3)
APLA: 
101802287(TGFB3)
TGU: 
100232487(TGFB3)
GFR: 
102037028(TGFB3)
FAB: 
101809258(TGFB3)
PHI: 
102102248(TGFB3)
CCW: 
104685280(TGFB3)
FPG: 
101912650(TGFB3)
FCH: 
102055453(TGFB3)
CLV: 
102088125(TGFB3)
ASN: 
102384560(TGFB3)
AMJ: 
102563668(TGFB3)
PSS: 
102456369(TGFB3)
CMY: 
102929710(TGFB3)
ACS: 
100551709(tgfb3)
PBI: 
103061116(TGFB3)
DRE: 
369195(tgfb3)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102358543(TGFB3)
CMK: 
VG: 
2700328(CNPV157)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Chen YG
  Title
Endocytic regulation of TGF-beta signaling.
  Journal
Cell Res 19:58-70 (2009)
Reference
  Authors
Bocharov EV, Korzhnev DM, Blommers MJ, Arvinte T, Orekhov VY, Billeter M, Arseniev AS
  Title
Dynamics-modulated biological activity of transforming growth factor beta3.
  Journal
J Biol Chem 277:46273-9 (2002)
  Sequence
[hsa:7043]

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