KEGG ORTHOLOGY: K13498

ORTHOLOGY: K13498

Entry

K13498 KO

Name

trpCF

Definition

indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24]

Pathway

ko00400

Phenylalanine, tyrosine and tryptophan biosynthesis

Module

M00023

Tryptophan biosynthesis, chorismate => tryptophan

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K13498  trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
KEGG pathway modules [BR:ko00002]
Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00023  Tryptophan biosynthesis, chorismate => tryptophan
     K13498  trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.48  indole-3-glycerol-phosphate synthase
     K13498  trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.1  Interconverting aldoses and ketoses, and related compounds
    5.3.1.24  phosphoribosylanthranilate isomerase
     K13498  trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase

Other DBs

RN:

R03508 R03509

COG:

COG0134 COG0135

GO:

0004425 0004640

Genes

ECO:	b1262(trpC)
ECJ:	Y75_p1236(trpC)
ECD:	ECDH10B_1377(trpC)
EBW:	BWG_1091(trpC)
ECOK:	ECMDS42_1057(trpC)
ECE:	Z2549(trpC)
ECS:	ECs1834(trpC)
ECF:	ECH74115_1894(trpC)
ETW:	ECSP_1781(trpC)
ELX:	CDCO157_1754
EOJ:	ECO26_1827(trpC)
EOI:	ECO111_1642(trpC)
EOH:	ECO103_1424(trpC)
ECG:	E2348C_1452(trpC)
EOK:	G2583_1601(trpC)
ELR:	ECO55CA74_07790
ECP:	ECP_1310(trpC)
ECI:	UTI89_C1531(trpC)
ECV:	APECO1_423(trpC)
ECX:	EcHS_A1371(trpC)
ECW:	EcE24377A_1461(trpC)
ECM:	EcSMS35_1870(trpC)
ECY:	ECSE_1311
ECR:	ECIAI1_1282(trpC)
ECQ:	ECED1_1469(trpC)
ECK:	EC55989_1420(trpC)
ECT:	ECIAI39_1599(trpC)
EOC:	CE10_1501(trpC)
EUM:	ECUMN_1561(trpC)
ECZ:	ECS88_1397(trpC)
ELO:	EC042_1388(trpC)
ELN:	NRG857_06480
ELH:	ETEC_1364
ESE:	ECSF_1240
ESO:	O3O_11595
ESM:	O3M_14010
ESL:	O3K_14035
ECL:	EcolC_2365
EBR:	ECB_01236(trpC)
EBD:	ECBD_2360
EKO:	EKO11_2589
EKF:	KO11_16515(trpC)
EAB:	ECABU_c15430(trpC)
EDH:	EcDH1_2386
EDJ:	ECDH1ME8569_1202(trpC)
EIH:	ECOK1_1474(trpC)
ENA:	ECNA114_1450(trpC)
ELU:	UM146_10470
EUN:	UMNK88_1592
ELW:	ECW_m1354(trpC)
ELL:	WFL_06600(trpC)
ELC:	i14_1559(trpC)
ELD:	i02_1559(trpC)
ELP:	P12B_c1828(trpC)
EBL:	ECD_01236(trpC)
EBE:	B21_01246(trpC)
ELF:	LF82_2311(trpC)
ECOA:	APECO78_10175
EFE:	EFER_1694(trpC)
EBT:	EBL_c16090(trpC)
STY:	STY1326(trpC)
STT:	t1637(trpC)
SEX:	STBHUCCB_17390
STM:	STM1725(trpC)
SEO:	STM14_2088(trpC)
SEV:	STMMW_17201
SEY:	SL1344_1656(trpC)
SEM:	STMDT12_C17480
SEJ:	STMUK_1697(trpF)
SEB:	STM474_1742(trpC)
SEF:	UMN798_1816(trpC)
SPT:	SPA1152(trpC)
SEK:	SSPA1071
SPQ:	SPAB_01520
SEI:	SPC_2004(trpC)
SEC:	SC1721(trpC)
SEH:	SeHA_C1915
SHB:	SU5_02333
SEE:	SNSL254_A1852
SEW:	SeSA_A1857
SEA:	SeAg_B1421
SED:	SeD_A1603
SEG:	SG1390(trpC)
SEL:	SPUL_1538(trpC)
SET:	SEN1309(trpC)
SENJ:	CFSAN001992_02835
SES:	SARI_01230
SBG:	SBG_1587(trpC)
YPE:	YPO2205(trpC)
YPK:	y2049(trpC)
YPA:	YPA_1565(trpC)
YPN:	YPN_1674(trpC)
YPM:	YP_2003(trpC)
YPP:	YPDSF_0928(trpC; trpF)
YPG:	YpAngola_A2315(trpC)
YPZ:	YPZ3_1645(trpC)
YPT:	A1122_15115
YPD:	YPD4_1939(trpC)
YPX:	YPD8_1326(trpC)
YPH:	YPC_1833(trpC)
YPS:	YPTB2127(trpC)
YPI:	YpsIP31758_1935(trpC)
YPY:	YPK_2045
YPB:	YPTS_2198
YEN:	YE2212(trpC)
YEP:	YE105_C2258
YEY:	Y11_10781
SFL:	SF1265(trpC)
SFX:	S1351(trpC)
SFV:	SFV_1276(trpC)
SFE:	SFxv_1437(trpC)
SSN:	SSON_1881(trpC)
SSJ:	SSON53_11100
SBO:	SBO_1804(trpC)
SBC:	SbBS512_E1487(trpC)
SDY:	SDY_1330(trpC)
ECA:	ECA2299(trpC)
PCT:	PC1_2004
PCC:	PCC21_020620
PWA:	Pecwa_2303
PEC:	W5S_2248
ETA:	ETA_16010(trpC)
EPY:	EpC_16710(trpC)
EPR:	EPYR_01797(trpC)
EAM:	EAMY_1918(trpC)
EAY:	EAM_1880(trpC)
EBI:	EbC_23810(trpC)
ERJ:	EJP617_30230(trpC)
PLU:	plu2465(trpC)
PAY:	PAU_02052(trpC)
BUC:	BU279(trpC)
BAS:	BUsg268(trpC)
BAB:	bbp259(trpC)
BAP:	BUAP5A_274(trpC)
BAU:	BUAPTUC7_276(trpC)
BAK:	BAKON_281(trpC)
BAW:	CWU_01825
BAJC:	CWS_01450
BUA:	CWO_01460
BUH:	BUAMB_260(trpC)
BAJ:	BCTU_182(trpc)
SGL:	SG1399(trpC)
ENT:	Ent638_2206(trpC)
ENC:	ECL_01727
ENO:	ECENHK_12440
ECLO:	ENC_08230
ESC:	Entcl_2525
EEC:	EcWSU1_02520(trpC)
ENL:	A3UG_12880
EAS:	Entas_2377
EAE:	EAE_21425
EAR:	ST548_p7407
ESA:	ESA_01560
CSK:	ES15_1789(trpCF)
CSZ:	CSSP291_07535
CTU:	CTU_23580(trpC)
KPN:	KPN_01255(trpC)
KPU:	KP1_2296(trpC)
KPM:	KPHS_21610
KPP:	A79E_2925
KPE:	KPK_3181(trpC)
KPO:	KPN2242_09410
KVA:	Kvar_3055
KOX:	KOX_18335
CKO:	CKO_01338
CRO:	ROD_17411(trpC)
SPE:	Spro_2670
SRR:	SerAS9_2664
SRS:	SerAS12_2665
SRA:	SerAS13_2666
SSZ:	SCc_378(trpC)
SMAF:	D781_2420
SMW:	SMWW4_v1c26800(trpC)
PMR:	PMI1346(trpC)
EIC:	NT01EI_1689
ETR:	ETAE_1532(trpC)
ETD:	ETAF_1421
ETC:	ETAC_07185
BFL:	Bfl429(trpC)
BPN:	BPEN_441(trpC)
BVA:	BVAF_430(trpC)
BCHR:	BCHRO640_453(trpC)
DDA:	Dd703_1935
DDC:	Dd586_2122
DDD:	Dda3937_00574(trpC)
DZE:	Dd1591_2175
XBO:	XBJ1_2276(trpC)
XNE:	XNC1_2436(trpC)
PAM:	PANA_2068(trpC)
PLF:	PANA5342_2104(trpC)
PAJ:	PAJ_1391(trpC)
PAQ:	PAGR_g2026
PVA:	Pvag_1507(trpC)
PAO:	Pat9b_2089
RAH:	Rahaq_2620
RAQ:	Rahaq2_2056
RAA:	Q7S_13045
MEN:	MEPCIT_112
MEO:	MPC_423(trpC)
PSI:	S70_00535
MMK:	MU9_2281
SECT:	A359_07570
SEHC:	A35E_00050
EBF:	D782_2445
HIN:	HI1389.1(trpC)
HIT:	NTHI1763(trpC)
HIP:	CGSHiEE_04515(trpC)
HIQ:	CGSHiGG_00715(trpC)
HIF:	HIBPF07560
HIL:	HICON_17070
HIU:	HIB_15610
HIE:	R2846_0871(trpCF)
HIZ:	R2866_1010(trpCF)
HAP:	HAPS_1994(trpC)
HPR:	PARA_16910
HSM:	HSM_1312
PMU:	PM0580(trpC)
PMV:	PMCN06_0610(trpC)
PUL:	NT08PM_0720
PMP:	Pmu_06470(trpC)
MSU:	MS1152(trpC)
MHT:	D648_10000
MHQ:	D650_17570
APL:	APL_0859(trpCF)
APJ:	APJL_0870(trpCF)
APA:	APP7_0918
ASU:	Asuc_1269
ASI:	ASU2_04940
AAP:	NT05HA_0811
AAT:	D11S_1374
AAO:	ANH9381_1720
AAN:	D7S_00035
GAN:	UMN179_00018
BTO:	WQG_8740
VCH:	VC1171(trpC)
VCE:	Vch1786_I0675
VCJ:	VCD_003172
VCO:	VC0395_A0793(trpC_F)
VCR:	VC395_1290(trpC_F)
VCM:	VCM66_1126(trpC_F)
VCI:	O3Y_05465
VCL:	VCLMA_A1024
VVU:	VV1_3067
VVY:	VV1218(trpC)
VVM:	VVMO6_01999
VPA:	VP1959(trpC)
VPB:	VPBB_1800
VHA:	VIBHAR_02761
VSP:	VS_1969
VEX:	VEA_003085
VEJ:	VEJY3_10270
VFU:	vfu_A02221
VFI:	VF_1029(trpC)
VFM:	VFMJ11_1112
VSA:	VSAL_I1151(trpC)
PPR:	PBPRA2489(trpC)
VAN:	VAA_02250
SON:	SO_3022(trpCF)
SDN:	Sden_2453(trpC)
SFR:	Sfri_1426(trpC)
SAZ:	Sama_2132(trpC)
SBL:	Sbal_2704(trpC)
SBM:	Shew185_2725
SBN:	Sbal195_2804
SBP:	Sbal223_1661
SBT:	Sbal678_2810
SBS:	Sbal117_2837
SBB:	Sbal175_1644
SLO:	Shew_2254(trpC)
SPC:	Sputcn32_2406(trpC)
SHP:	Sput200_2434
SSE:	Ssed_1683
SPL:	Spea_1587
SHE:	Shewmr4_1459(trpC)
SHM:	Shewmr7_1525(trpC)
SHN:	Shewana3_1517(trpC)
SHW:	Sputw3181_1602(trpC)
SHL:	Shal_1655
SWD:	Swoo_2915
SWP:	swp_1920
SVO:	SVI_2806(trpCF)
ILO:	IL1754(trpC)
CPS:	CPS_3525(trpC_F)
PHA:	PSHAa1290(trpCF)
PAT:	Patl_2832(trpC)
PSM:	PSM_A1706(trpCF)
AMC:	MADE_1006885
AMAC:	MASE_06465
AMB:	AMBAS45_06770
AMG:	AMEC673_06530
AMK:	AMBLS11_06525
AMAA:	amad1_07345
ALT:	ambt_11660
GAG:	Glaag_2908
GNI:	GNIT_1434(trpCF)
GPS:	C427_3988
PIN:	Ping_1057(trpC)
PSY:	PCNPT3_03925
FBL:	Fbal_2539
FTU:	FTT_1795c(trpC)
FTF:	FTF1795c(trpC)
FTW:	FTW_2017(trpCF)
FTR:	NE061598_10460
FTT:	FTV_1707(trpC)
FTG:	FTU_1792(trpC)
FTL:	FTL_1958(trpC)
FTH:	FTH_1875(trpC_trpF)
FTA:	FTA_2071(trpCF)
FTS:	F92_10865
FTI:	FTS_1904(trpCF)
FTM:	FTM_1744(trpC)
FTN:	FTN_1770(trpC)
FCF:	FNFX1_1808
FCN:	FN3523_1845
FPH:	Fphi_0834
FRT:	F7308_1972
FNA:	OOM_1830
KKO:	Kkor_1644
AHA:	AHA_2926(trpCF)
ASA:	ASA_1404(trpC)
AVR:	B565_2825
TAU:	Tola_0941
OCE:	GU3_12585
HPY:	HP1279(trpC)
HEO:	C694_06610
HPJ:	jhp1200(trpC)
HPA:	HPAG1_1233(trpC)
HPS:	HPSH_06625
HHP:	HPSH112_06415
HHQ:	HPSH169_06360
HHR:	HPSH417_06285
HPG:	HPG27_1225
HPP:	HPP12_1245(trpC)
HPB:	HELPY_1256(trpCF)
HPL:	HPB8_201(trpCF)
HPC:	HPPC_06290
HCA:	HPPC18_06400
HPM:	HPSJM_06415
HPE:	HPELS_06645
HPO:	HMPREF4655_21472(trpC2)
HPI:	hp908_1279(trpC)
HPQ:	hp2017_1238(trpC)
HPW:	hp2018_1243(trpC)
HPU:	HPCU_06550
HEF:	HPF16_1213(trpC)
HPF:	HPF30_0118(trpC)
HEQ:	HPF32_1208(trpC)
HEX:	HPF57_1238(trpC)
HPT:	HPSAT_06185
HPZ:	HPKB_1215
HPV:	HPV225_1313
HPX:	HMPREF0462_1295(trpC2)
HEN:	HPSNT_06430
HPH:	HPLT_06425
HEG:	HPGAM_06620
HPN:	HPIN_06745
HEP:	HPPN120_06290
HEU:	HPPN135_06570
HES:	HPSA_06290
HCN:	HPB14_06150
HPD:	KHP_1175(trpC)
HEY:	MWE_1488
HER:	C695_06620
HEI:	C730_06620
HPYA:	HPAKL117_06075
HPYK:	HPAKL86_00300
HPYO:	HPOK113_1234(trpC)
HPYL:	HPOK310_1171(trpC)
HAC:	Hac_0015(trpC)
HMS:	HMU05770
HFE:	HFELIS_01960
HBI:	HBZC1_14240
HCE:	HCW_01985
HCM:	HCD_00555
HCB:	HCBAA847_0859
DAT:	HRM2_17680(trpC)
SCL:	sce1101(trpC)
LCC:	B488_13090
BCK:	BCO26_2346(trp1)
BAG:	Bcoa_2095
VPR:	Vpar_0161
CGL:	NCgl2930(trpC)
CGB:	cg3362(trpCF)
CGU:	WA5_2930(TrpCF)
CGT:	cgR_2919(trpC)
CEF:	CE2871(trpC)
CDI:	DIP2355(trpC1)
CDP:	CD241_2235(trpC1)
CDH:	CDB402_2213(trpC1)
CDT:	CDHC01_2235(trpC1)
CDE:	CDHC02_2219(trpC1)
CDR:	CDHC03_2243(trpC1)
CDA:	CDHC04_2254(trpC1)
CDZ:	CD31A_2377(trpC1)
CDB:	CDBH8_2350(trpC1)
CDS:	CDC7B_2328(trpC1)
CDD:	CDCE8392_2245(trpC1)
CDW:	CDPW8_2335(trpC1)
CDV:	CDVA01_2171(trpC1)
CAR:	cauri_2510(trpC2)
CPU:	cpfrc_02086(trpC1)
CPL:	Cp3995_2151(trpC)
CPG:	Cp316_2148(trpC)
CPP:	CpP54B96_2120(trpC)
CPK:	Cp1002_2086(trpC)
CPQ:	CpC231_2079(trpC)
CPX:	CpI19_2100(trpC)
CPZ:	CpPAT10_2089(trpC)
COR:	Cp267_2163(trpC)
COP:	Cp31_2084(trpC)
COD:	Cp106_2042(trpC)
COS:	Cp4202_2077(trpC)
COI:	CpCIP5297_2114(trpC)
COE:	Cp258_2108(trpC)
COU:	Cp162_2064(trpC)
CUL:	CULC22_02330(trpC1)
CUC:	CULC809_02173(trpC1)
CUE:	CULC0102_2327(trpC1)
CHN:	A605_13925
CCN:	H924_12735
TBE:	Trebr_1624
SSM:	Spirs_4122
STA:	STHERM_c01830
STQ:	Spith_0167
SFC:	Spiaf_2549
CTM:	Cabther_A0901
FSC:	FSU_0580(trpCF)
DPT:	Deipr_2107

» show all

Reference

PMID:7014916

Authors

Kirschner K, Szadkowski H, Henschen A, Lottspeich F

Title

Limited proteolysis of N-(5'-phosphoribosyl)anthranilate isomerase: indoleglycerol phosphate synthase from Escherichia coli yields two different enzymically active, functional domains.

Journal

J Mol Biol 143:395-409 (1980)

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Ontology (7)   
   KEGG BRITE (3)   
   GO (2)   
   COG (2)   
Pathway (1632)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1624)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (3217)   
   KEGG GENES (428)   
   KEGG EGENES (1)   
   KEGG MGENES (2788)   
Protein sequence (384)   
   UniProt (384)   
Literature (1)   
   PubMed (1)   
All databases (5247)   

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