KEGG   ORTHOLOGY: K13546
Entry
K13546                      KO                                     
Symbol
btrC, neoC, kanC
Name
2-deoxy-scyllo-inosose synthase [EC:4.2.3.124]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08617  D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13546  btrC, neoC, kanC; 2-deoxy-scyllo-inosose synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.124  2-deoxy-scyllo-inosose synthase
     K13546  btrC, neoC, kanC; 2-deoxy-scyllo-inosose synthase
Genes
PMUY: KSS95_17135
PCEL: HUB94_17995
RPAY: P0092_07390 P0092_17075
NTC: KHQ06_25010
NHU: H0264_36135
NYA: LTV02_00425
SRN: A4G23_05128(kanC)
SFB: CP974_27365
SOV: QZH56_04570
NFS: OIE67_09815
DVC: Dvina_26405
AG: BAD95820(neoC) BAE07067(btrC) CAE46939(kanC)
 » show all
Reference
PMID:16156513 (btrC)
  Authors
Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K
  Title
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
  Journal
J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47
  Sequence
[ag:BAE07067]
Reference
PMID:16506694 (neoC)
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104
  Sequence
[ag:BAD95820]
Reference
PMID:15313224 (kanC)
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAE46939]
Reference
PMID:19362652
  Authors
Kudo F, Eguchi T
  Title
Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.
  Journal
Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5
Reference
PMID:17879343
  Authors
Nango E, Kumasaka T, Hirayama T, Tanaka N, Eguchi T
  Title
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+.
  Journal
Proteins 70:517-27 (2008)
DOI:10.1002/prot.21526

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (16)   
   KEGG GENES (15)   
   OC (1)   
Literature (5)   
   PubMed (5)   
All databases (30)   

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