KEGG   ORTHOLOGY: K13553Help
Entry
K13553                      KO                                     

Name
btrB, neoN, kacL
Definition
neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase [EC:2.6.1.93 2.6.1.94 2.6.1.95]
Pathway
Butirosin and neomycin biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Biosynthesis of other secondary metabolites
   00524 Butirosin and neomycin biosynthesis
    K13553  btrB, neoN, kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.93  neamine transaminase
     K13553  btrB, neoN, kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase
    2.6.1.94  2'-deamino-2'-hydroxyneamine transaminase
     K13553  btrB, neoN, kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase
    2.6.1.95  neomycin C transaminase
     K13553  btrB, neoN, kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class III
   K13553  btrB, neoN, kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase / neomycin C transaminase
BRITE hierarchy
Other DBs
Genes
AG: 
BAD95831(neoN) BAE07066(btrB) CAF60533(kacL)
TaxonomyKoalaUniProt
Reference
PMID:16156513 (btrB)
  Authors
Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K
  Title
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
  Journal
J Antibiot (Tokyo) 58:373-9 (2005)
  Sequence
Reference
PMID:16506694 (neoN)
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
  Sequence
Reference
PMID:15313224 (kanB)
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
  Sequence
Reference
  Authors
Kudo F, Eguchi T
  Title
Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.
  Journal
Methods Enzymol 459:493-519 (2009)
Reference
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem 8:283-8 (2007)

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