KEGG ORTHOLOGY: K13938

ORTHOLOGY: K13938

Entry

K13938 KO

Name

folM

Definition

dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.- 1.5.1.3]

Pathway

ko00670	One carbon pool by folate
ko00790	Folate biosynthesis

Module

M00126

Tetrahydrofolate biosynthesis, GTP => THF

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13938  folM; dihydromonapterin reductase / dihydrofolate reductase
   00670 One carbon pool by folate
    K13938  folM; dihydromonapterin reductase / dihydrofolate reductase
KEGG pathway modules [BR:ko00002]
Pathway module
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00126  Tetrahydrofolate biosynthesis, GTP => THF
     K13938  folM; dihydromonapterin reductase / dihydrofolate reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13938  folM; dihydromonapterin reductase / dihydrofolate reductase
    1.5.1.-
     K13938  folM; dihydromonapterin reductase / dihydrofolate reductase

Other DBs

RN:

R00936 R00939

COG:

COG1028

GO:

0004146

Genes

ECO:	b1606(folM)
ECJ:	Y75_p1582(folM)
ECD:	ECDH10B_1739(folM)
EBW:	BWG_1421(folM)
ECOK:	ECMDS42_1276(folM)
ECE:	Z2606(ydgB)
ECS:	ECs2312
ECF:	ECH74115_2317
ETW:	ECSP_2170(folM)
ELX:	CDCO157_2149
EOJ:	ECO26_2334(folM)
EOI:	ECO111_2075(folM)
EOH:	ECO103_1746(folM)
ECG:	E2348C_1691(folM)
EOK:	G2583_2000(folM)
ELR:	ECO55CA74_09820
ECC:	c1998(ydgB)
ECP:	ECP_1550
ECI:	UTI89_C1794(ydgB)
ECV:	APECO1_689(ydgB)
ECX:	EcHS_A1681
ECW:	EcE24377A_1815
ECM:	EcSMS35_1592
ECY:	ECSE_1727
ECR:	ECIAI1_1656(folM)
ECQ:	ECED1_1805(folM)
ECK:	EC55989_1771(folM)
ECT:	ECIAI39_1452(folM)
EOC:	CE10_1878(folM)
EUM:	ECUMN_1894(folM)
ECZ:	ECS88_1651(folM)
ELO:	EC042_1774
ELN:	NRG857_08045
ELH:	ETEC_1640
ESE:	ECSF_1467
ESO:	O3O_13430
ESM:	O3M_12170
ESL:	O3K_12205
ECL:	EcolC_2024
EBR:	ECB_01575(ydgB)
EBD:	ECBD_2040
EKO:	EKO11_2171
EKF:	KO11_14725(folM)
EAB:	ECABU_c18020(ydgB)
EDH:	EcDH1_2037
EDJ:	ECDH1ME8569_1549(folM)
EIH:	ECOK1_1725
ENA:	ECNA114_1653
ELU:	UM146_09135
EUN:	UMNK88_2066
ELW:	ECW_m1771(folM)
ELL:	WFL_08675(folM)
ELC:	i14_1818(ydgB)
ELD:	i02_1818(ydgB)
ELP:	P12B_c1477(ydgB)
EBL:	ECD_01575(ydgB)
EBE:	B21_01565(folM)
ELF:	LF82_0727(folM)
ECOA:	APECO78_11835
EFE:	EFER_1431(folM)
EBT:	EBL_c22390(ydgB)
SFL:	SF1627(ydgB)
SFX:	S1759(ydgB)
SFV:	SFV_1621(ydgB)
SFE:	SFxv_1823(folM)
SSN:	SSON_1554(ydgB)
SSJ:	SSON53_09485
SBO:	SBO_1530(ydgB)
SBC:	SbBS512_E1793
SDY:	SDY_1547(ydgB)
ECA:	ECA2018
PCT:	PC1_2270
PCC:	PCC21_023440
PWA:	Pecwa_2577
PEC:	W5S_2552
ENT:	Ent638_1846
ENC:	ECL_02267
ENO:	ECENHK_09765
ESC:	Entcl_2239
EEC:	EcWSU1_01946(folM)
ENL:	A3UG_09805
EAS:	Entas_1862
EAE:	EAE_18090
EAR:	ST548_p6783
CSK:	ES15_2112(folB2)
CSZ:	CSSP291_09355
CTU:	CTU_20270(folM)
KPN:	KPN_01523(ydgB)
KPU:	KP1_2533(ydgB)
KPM:	KPHS_24270
KPP:	A79E_2714
KPE:	KPK_2936
KPO:	KPN2242_10400
KVA:	Kvar_2835
KOX:	KOX_21840
CKO:	CKO_01615
CRO:	ROD_14581
SPE:	Spro_2589
SRR:	SerAS9_2583
SRS:	SerAS12_2584
SRA:	SerAS13_2585
SMAF:	D781_2166
SMW:	SMWW4_v1c25720(folM)
EIC:	NT01EI_1953
ETR:	ETAE_1753
ETD:	ETAF_1585(folM)
ETC:	ETAC_08045
EBF:	D782_2069
GAN:	UMN179_02469
VSP:	VS_1751
PAE:	PA3437(folM)
PAU:	PA14_19640(ydgB)
PAP:	PSPA7_1691
PAG:	PLES_16241
PAF:	PAM18_1529
PNC:	NCGM2_4574(ydgB)
PDK:	PADK2_07080
PPU:	PP_4632
PPF:	Pput_4493
PPG:	PputGB1_4617
PPW:	PputW619_0808
PPT:	PPS_4459
PPB:	PPUBIRD1_4327
PPI:	YSA_03200
PPX:	T1E_1546(ydgB)
PPUH:	B479_22425
PPUU:	PputUW4_00811
PST:	PSPTO_1183
PSB:	Psyr_1021
PSP:	PSPPH_1072
PFL:	PFL_0950
PFO:	Pfl01_0892
PFS:	PFLU5157
PFE:	PSF113_4877(folM)
PFC:	PflA506_4449
PPZ:	H045_16465
PEN:	PSEEN4623
PMY:	Pmen_3288
PMK:	MDS_3590
PSA:	PST_1136
PSZ:	PSTAB_1040
PSR:	PSTAA_1097
PSC:	A458_16075
PSJ:	PSJM300_15010
PSH:	Psest_3204
PBA:	PSEBR_a4711
PFV:	Psefu_1347
PDR:	H681_19955
AVN:	Avin_10270
SON:	SO_0772(folM)
SDN:	Sden_0827
SFR:	Sfri_3161
SBL:	Sbal_0611
SBM:	Shew185_3683
SBN:	Sbal195_3807
SBP:	Sbal223_3625
SBT:	Sbal678_3837
SBS:	Sbal117_0748
SBB:	Sbal175_3604
SLO:	Shew_0048
SPC:	Sputcn32_3217
SHP:	Sput200_3351
SHE:	Shewmr4_3337
SHM:	Shewmr7_0616
SHN:	Shewana3_3507
SHW:	Sputw3181_0724
SWD:	Swoo_0378
SWP:	swp_0144
ILO:	IL1531
PHA:	PSHAa0074(folM)
PSM:	PSM_A0075(folM)
MAD:	HP15_3719
AMAC:	MASE_17655
AMB:	AMBAS45_18060
AMG:	AMEC673_17790
AMK:	AMBLS11_17145
AMAA:	amad1_18655
GNI:	GNIT_3073(folM)
FBL:	Fbal_1510
TCX:	Tcr_1865
TCY:	Thicy_0293
MEJ:	Q7A_335
MEC:	Q7C_2015
HNA:	Hneap_2118
HCH:	HCH_00526
CSA:	Csal_0587
HEL:	HELO_3782(ydgB)
MMW:	Mmwyl1_3287
MME:	Marme_1314
MPC:	Mar181_0947
TOL:	TOL_1022
AHA:	AHA_4063
ASA:	ASA_0252
AVR:	B565_3760
GPB:	HDN1F_04320
ABS:	AZOBR_10100(folM)

» show all

Reference

PMID:14617668

Authors

Giladi M, Altman-Price N, Levin I, Levy L, Mevarech M

Title

FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.

Journal

J Bacteriol 185:7015-8 (2003)

Reference

PMID:19897652

Authors

Pribat A, Blaby IK, Lara-Nunez A, Gregory JF 3rd, de Crecy-Lagard V, Hanson AD

Title

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.

Journal

J Bacteriol 192:475-82 (2010)

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Ontology (8)   
   KEGG BRITE (6)   
   GO (1)   
   COG (1)   
Pathway (674)   
   KEGG PATHWAY (6)   
   KEGG MODULE (668)   
Drug (9)   
   KEGG DRUG (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (223)   
   KEGG GENES (196)   
   KEGG DGENES (1)   
   KEGG MGENES (26)   
Protein sequence (172)   
   UniProt (172)   
Literature (2)   
   PubMed (2)   
All databases (1092)   

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