KEGG   ORTHOLOGY: K13939Help
Entry
K13939                      KO                                     

Name
FOL1
Definition
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15]
Pathway
Folate biosynthesis
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00126  Tetrahydrofolate biosynthesis, GTP => THF
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.15  dihydropteroate synthase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
  2.7  Transferring phosphorus-containing groups
   2.7.6  Diphosphotransferases
    2.7.6.3  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.25  dihydroneopterin aldolase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
BRITE hierarchy
Other DBs
Genes
SCE: 
YNL256W(FOL1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A00710(NCAS0A00710)
NDI: 
NDAI_0F04090(NDAI0F04090)
TPF: 
TPHA_0B04280(TPHA0B04280)
TBL: 
TBLA_0A05660(TBLA0A05660)
TDL: 
TDEL_0C05970(TDEL0C05970)
KAF: 
KAFR_0D03830(KAFR0D03830)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.579(FOL1) CaO19.8210(FOL1)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
SPO: 
CNE: 
CNB: 
CGI: 
CCI: 
EHE: 
DDI: 
DPP: 
DFA: 
DFA_08871(fol1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lawrence MC, Iliades P, Fernley RT, Berglez J, Pilling PA, Macreadie IG
  Title
The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
  Journal
J Mol Biol 348:655-70 (2005)
Reference
  Authors
Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH
  Title
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1  carrier induces pseudohyphal growth.
  Journal
Mol Biol Cell 15:3811-28 (2004)

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