KEGG   ORTHOLOGY: K13998Help
Entry
K13998                      KO                                     

Name
DHFR-TS
Definition
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Pathway
ko00240  Pyrimidine metabolism
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
Module
M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   00670 One carbon pool by folate
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Pyrimidine metabolism
    M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   Cofactor and vitamin biosynthesis
    M00126  Tetrahydrofolate biosynthesis, GTP => THF
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
    M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
BRITE hierarchy
Other DBs
RN: R00936 R00937 R00939 R00940 R02101 R02235 R02236
GO: 0004146 0004799
Genes
RSS: 109442081
ATH: AT2G16370(THY-1) AT4G34570(THY-2)
ALY: ARALYDRAFT_480800 ARALYDRAFT_656540 ARALYDRAFT_667353
CRB: 17877840 17887860 17891157
CSAT: 104702701 104713608 104716677 104721335 104729758 104747430 104751813 104766934 104792357
EUS: EUTSA_v10000156mg EUTSA_v10022646mg EUTSA_v10024973mg
BRP: 103836808 103858399 103860451 103862355
BNA: 106354095 106393759 106406829 106428737 106442422
BOE: 106309714 106328327 106329435
THJ: 104807303 104819616 104824813
CPAP: 110810494
CIT: 102610005
LJA: Lj1g3v3381400.1(Lj1g3v3381400.1) Lj1g3v3381400.2(Lj1g3v3381400.2) Lj3g3v3363560.1(Lj3g3v3363560.1)
FVE: 101310472
PPER: 18768793
PMUM: 103335682
PAVI: 110768489
PXB: 103967122
CSV: 101208660
CMO: 103499691
MCHA: 111015400
JCU: 105630137
SLY: 101267455
SPEN: 107008381
SOT: 102593228
CANN: 107840424
NTO: 104105538
SIND: 105159256
BVG: 104904324
SOE: 110803064
NNU: 104595633
DOSA: Os11t0484400-01(Os11g0484400) Os12t0446900-01(Os12g0446900)
BDI: 100832991
ATS: 109782258(LOC109782258)
SBI: 8068714
ZMA: 100286018(umc1821) 103644908 103653497 541707(DRTS)
MUS: 103975558
AOF: 109830591
ATR: 18437260
PPP: 112291384
MIS: MICPUN_58650(DHFR-TS)
MPP: MICPUCDRAFT_56456(DHFR-TS)
APRO: F751_2439
PYO: PY17X_0719300(PY04370)
PCB: PCHAS_072830(PC000873.02.0)
TAN: TA08775
TPV: TP04_0504
BBO: BBOV_II000780(18.m06049)
CPV: cgd4_4460
TPS: THAPS_13647(TMS1)
SPAR: SPRG_06761
TCR: 509153.90
LMA: LMJF_06_0860(DHFR-TS)
LIF: LINJ_06_0890(DHFR-TS)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8374616
  Authors
Lazar G, Zhang H, Goodman HM
  Title
The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.
  Journal
Plant J 3:657-68 (1993)
DOI:10.1111/j.1365-313X.1993.00657.x
Reference
PMID:8628226
  Authors
Schlichtherle IM, Roos DS, Van Houten JL
  Title
Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia.
  Journal
Mol Gen Genet 250:665-73 (1996)
DOI:10.1007/BF02172977

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