KEGG   ORTHOLOGY: K13998Help
Entry
K13998                      KO                                     
Name
DHFR-TS
Definition
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Module
M00053  
Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   00670 One carbon pool by folate
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Pyrimidine metabolism
    M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   Cofactor and vitamin biosynthesis
    M00126  Tetrahydrofolate biosynthesis, GTP => THF
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
BRITE hierarchy
Other DBs
Genes
ATH: 
AT2G16370(THY-1) AT4G34570(THY-2)
ALY: 
GMX: 
MTR: 
CSV: 
RCU: 
POP: 
POPTR_648629(DHFR-TS-1) POPTR_649387(DHFR-TS-2)
VVI: 
OSA: 
DOSA: 
Os11t0484400-01(Os11g0484400) Os12t0446900-01(Os12g0446900)
BDI: 
100832991
SBI: 
SORBI_05g016730(SORBIDRAFT_05g016730)
ZMA: 
100286018(umc1821) 541707(DRTS)
SMO: 
SELMODRAFT_233517 SELMODRAFT_404548
PPP: 
PHYPADRAFT_120817
CRE: 
CHLREDRAFT_139742
VCN: 
VOLCADRAFT_66296
OLU: 
OSTLU_49676
OTA: 
Ot01g05780
CME: 
CMS462C
NGR: 
NAEGRDRAFT_76251
PFA: 
PFD0805w
PFD: 
PFDG_04158
PYO: 
PY04370
PCB: 
PC000873.02.0
PBE: 
PB000415.02.0
PKN: 
PKH_052130
PVX: 
PVX_089950
PCY: 
PCYB_053150
TAN: 
TA08775
TPV: 
TP04_0504
BBO: 
BBOV_II000780(18.m06049)
CPV: 
cgd4_4460
CHO: 
Chro.40506
TGO: 
TGME49_049180
TET: 
TTHERM_00312120
PTM: 
GSPATT00019973001
TBR: 
Tb927.7.5480(Tb07.10C21.550)
TCR: 
509153.90
LMA: 
LMJF_06_0860(DHFR-TS)
LIF: 
LINJ_06_0890(DHFR-TS)
LDO: 
LDBPK_060890
LMI: 
LMXM_06_0860
LBZ: 
LBRM_06_0830
PTI: 
PHATRDRAFT_1690
TPS: 
THAPS_13647(TMS1)
PIF: 
PITG_06749
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8374616
  Authors
Lazar G, Zhang H, Goodman HM
  Title
The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.
  Journal
Plant J 3:657-68 (1993)
Reference
PMID:8628226
  Authors
Schlichtherle IM, Roos DS, Van Houten JL
  Title
Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia.
  Journal
Mol Gen Genet 250:665-73 (1996)
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