KEGG   ORTHOLOGY: K13998Help
Entry
K13998                      KO                                     

Name
DHFR-TS
Definition
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Module
M00053  
Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   00670 One carbon pool by folate
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Pyrimidine metabolism
    M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   Cofactor and vitamin biosynthesis
    M00126  Tetrahydrofolate biosynthesis, GTP => THF
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
BRITE hierarchy
Other DBs
Genes
ATH: 
AT2G16370(THY-1) AT4G34570(THY-2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0004s16470g(POPTRDRAFT_648629) POPTR_0005s25200g(POPTRDRAFT_818754) POPTR_0005s25230g(POPTRDRAFT_559761) POPTR_0009s12200g(POPTRDRAFT_649387)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os11t0484400-01(Os11g0484400) Os12t0446900-01(Os12g0446900)
OBR: 
BDI: 
SBI: 
SORBI_05g016730(SORBIDRAFT_05g016730)
ZMA: 
100286018(umc1821) 541707(DRTS)
SITA: 
ATR: 
s00014p00122790(AMTR_s00014p00122790)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MICPUN_58650(DHFR-TS)
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
ACAN: 
PFA: 
PFD: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_II000780(18.m06049)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb927.7.5480(Tb07.10C21.550)
TCR: 
LMA: 
LMJF_06_0860(DHFR-TS)
LIF: 
LINJ_06_0890(DHFR-TS)
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8374616
  Authors
Lazar G, Zhang H, Goodman HM
  Title
The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.
  Journal
Plant J 3:657-68 (1993)
Reference
PMID:8628226
  Authors
Schlichtherle IM, Roos DS, Van Houten JL
  Title
Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia.
  Journal
Mol Gen Genet 250:665-73 (1996)

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