KEGG   ORTHOLOGY: K14443Help
Entry
K14443                      KO                                     

Name
TOB
Definition
protein Tob/BTG
Pathway
RNA degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   03018 RNA degradation
    K14443  TOB; protein Tob/BTG
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K14443  TOB; protein Tob/BTG
  mRNA degradation factors
   3'-5' decay
    Other 3'-5' decay factors
     K14443  TOB; protein Tob/BTG
BRITE hierarchy
Genes
HSA: 
10140(TOB1) 10766(TOB2) 10950(BTG3) 54766(BTG4) 694(BTG1) 7832(BTG2)
PTR: 
451538(BTG4) 452121(BTG1) 458865(TOB2) 468406(TOB1) 740912(BTG2) 749692(BTG3)
PPS: 
100968395(BTG1) 100972034(TOB1) 100985759(TOB2) 100990761(BTG2) 100991067(BTG3) 100994410(BTG4)
GGO: 
101125593(TOB2) 101131176(BTG4) 101138900(BTG1) 101144272(BTG2) 101147328(TOB1) 101148696(BTG3)
PON: 
NLE: 
100580263(BTG3) 100591230(TOB1) 100597059(BTG1) 100597985(TOB2) 100601505(BTG2) 100603682(BTG4)
MCC: 
703168(BTG2) 706873 707216(TOB2) 709946(BTG4) 710112(BTG1) 710579(BTG3)
MCF: 
CJC: 
100393479(TOB2) 100394994(BTG4) 100400853(BTG3) 100405025(BTG1) 100408523(TOB1) 100409458(BTG2) 100412192
MMU: 
12226(Btg1) 12227(Btg2) 12228(Btg3) 194735(Btg1-ps2) 22057(Tob1) 436199(Btg1-ps1) 56057(Btg4) 57259(Tob2)
RNO: 
170842(Tob1) 29618(Btg1) 29619(Btg2) 298349(RGD1563150) 315159(Tob2) 315650(Btg4) 367975 54230(Btg3)
CGE: 
100753614(Btg3) 100755272(Btg1) 100758626(Tob2) 100765745 100766229(Btg2) 100766688(Tob1) 100770985(Btg4)
NGI: 
103726365(Btg1) 103731861(Btg2) 103733911(Btg4) 103738401(Tob1) 103743175(Btg3) 103743480(Tob2)
HGL: 
OCU: 
100339845(TOB1) 100344815(BTG1) 100349594(BTG3) 100350876(BTG4) 100353216(TOB2) 100354553(BTG2)
TUP: 
CFA: 
100683517(TOB1) 100684605 481233(TOB2) 487695(BTG3) 488559(BTG2) 489412(BTG4)
AML: 
UMR: 
103657732(BTG2) 103660148(BTG1) 103660299(TOB1) 103662402(BTG4) 103673054(BTG3) 103674157(TOB2)
FCA: 
101082205(BTG2) 101089792(BTG3) 101091649(BTG4) 101098267(TOB1) 101100900(TOB2) 101101647(BTG1)
PTG: 
BTA: 
281032(BTG1) 507934(TOB2) 519995(BTG4) 539364(BTG2) 541054(BTG3) 768016(TOB1) 784737(TOB1)
BOM: 
102264973(BTG4) 102269714(BTG2) 102271631(BTG3) 102274438(TOB2) 102277659(TOB1)
PHD: 
102316624(BTG1) 102320500(TOB1) 102336327(TOB2) 102337049(BTG3) 102344416(BTG2) 102344812(BTG4)
CHX: 
100861579(BTG1) 102174632(BTG1) 102175142(BTG4) 102176267(BTG3) 102178391(TOB1) 102187789(BTG2) 102189933(TOB2)
OAS: 
100217400(BTG1) 100620046(TOB2) 100620047(BTG2) 100620049(BTG3) 101103823(TOB1) 101107134(BTG4)
SSC: 
100048932(BTG2) 100048957(BTG3) 100101473(BTG1) 100144440(TOB1) 100514308(BTG4)
CFR: 
102504534(BTG4) 102511283(BTG2) 102514585(TOB2) 102515218(TOB1) 102516093(BTG3) 102521231(BTG1)
BACU: 
102999833(BTG3) 103000964(TOB2) 103002894(BTG4) 103004439(BTG2) 103007363(TOB1) 103009536(BTG1)
LVE: 
ECB: 
100053122(BTG2) 100054048(BTG3) 100055713(TOB2) 100056451(TOB1) 100070324(BTG4) 100629230(BTG1)
MYB: 
102238930(BTG4) 102245347(BTG1) 102246373(BTG2) 102248369(BTG3) 102259223(TOB2) 102263921(TOB1)
MYD: 
102751671(BTG4) 102755542(BTG1) 102758616(TOB2) 102767619(BTG2) 102768869(BTG3) 102771873(TOB1)
PALE: 
102879693(BTG2) 102887122(BTG1) 102889076(BTG4) 102891712(TOB2) 102894615(TOB1) 102896420(BTG3)
MDO: 
SHR: 
100919144(BTG4) 100921611(BTG2) 100922495(TOB2) 100923528(BTG1) 100927519(TOB1)
OAA: 
100075807(TOB2) 100082540(BTG1) 100086417(BTG4) 100090433(BTG3) 100090471(TOB1)
GGA: 
395225(TOB1) 396295(BTG1) 417992(TOB2) 419781(BTG4) 419932(BTG2)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
100137619 379067(MGC52780) 380519(btg1) 394334(btg4-a) 397913(btg4-b) 398757(tob1) 399353(tob2) 446814(MGC75753-b) 447135 496081(btg2) 496384(btg-x) 734504(btg5) 735063(MGC75753-a)
XTR: 
100038251(btg3) 394487(MGC75753) 394522(btg1) 394613 496422(btg2) 548967(tob2) 549151(btg4) 549365(tob1) 613060(btg5) 733731
DRE: 
100007655(tob2) 100538016 114432(btg1) 30079(btg2) 378946(btg4) 386629(tob1a) 406245(tob1b) 492479(btg3) 492503(wu:fb11a09)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AAG: 
CQU: 
AME: 
100578925 410675(GB16183) 726804(GB10025)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
CBG12385(Cbr-fog-3)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
LEL: 
MRR: 
MBR: 
DDI: 
DFA: 
EHX: 
GTT: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F
  Title
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
  Journal
J Biol Chem 284:13244-55 (2009)
  Sequence
[hsa:10140]
Reference
  Authors
Doidge R, Mittal S, Aslam A, Winkler GS
  Title
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
  Journal
PLoS One 7:e51331 (2012)
  Sequence
[hsa:7832 10140]

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