KEGG   ORTHOLOGY: K14613Help
Entry
K14613                      KO                                     

Name
SLC46A1
Definition
MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Pathway
Antifolate resistance
Disease
H01252  
Hereditary folate malabsorption (HFM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Human Diseases
  Drug resistance
   01523 Antifolate resistance
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Transporters [BR:ko02000]
 Solute Carrier Family (SLC)
  SLC46: Folate transporter family
   K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
 Major Facilitator Superfamily (MFS)
  Organic acid transporters
   Proton coupled folate transporter/heme carrier protein (PCFT/HCP) family
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
BRITE hierarchy
Other DBs
Genes
HSA: 
113235(SLC46A1)
PTR: 
454527(SLC46A1)
PPS: 
100974524(SLC46A1)
GGO: 
101124330(SLC46A1)
PON: 
100440042(SLC46A1)
NLE: 
100599656(SLC46A1)
MCC: 
708727(SLC46A1)
MCF: 
102128999(SLC46A1)
CSAB: 
103242615(SLC46A1)
RRO: 
104669366(SLC46A1)
CJC: 
100411886(SLC46A1)
SBQ: 
101045373(SLC46A1)
MMU: 
52466(Slc46a1)
RNO: 
303333(Slc46a1)
CGE: 
100757832(Slc46a1)
NGI: 
103724487(Slc46a1)
HGL: 
101706680(Slc46a1)
CCAN: 
109698359(Slc46a1)
OCU: 
100009317(SLC46A1)
TUP: 
102487532(SLC46A1)
CFA: 
491166(SLC46A1)
AML: 
100468045(SLC46A1)
UMR: 
103667230(SLC46A1)
FCA: 
101100096(SLC46A1)
PTG: 
102952124(SLC46A1)
AJU: 
106983255(SLC46A1)
BTA: 
511097(SLC46A1)
BOM: 
102275758(SLC46A1)
BIU: 
109574229(SLC46A1)
PHD: 
102320978(SLC46A1)
CHX: 
102191550(SLC46A1)
OAS: 
101119738(SLC46A1)
SSC: 
100628018(SLC46A1)
CFR: 
102520521(SLC46A1)
BACU: 
103001026(SLC46A1)
LVE: 
103077796(SLC46A1)
ECB: 
100072047(SLC46A1)
MYB: 
102251643(SLC46A1)
MYD: 
102762830(SLC46A1)
HAI: 
109385141(SLC46A1)
PALE: 
102893216(SLC46A1)
LAV: 
100654339(SLC46A1)
MDO: 
100024595(SLC46A1)
SHR: 
100929844(SLC46A1)
OAA: 
100075532(SLC46A1)
GGA: 
417569(SLC46A1)
MGP: 
100543022(SLC46A1)
CJO: 
107322471(SLC46A1)
APLA: 
101800835(SLC46A1)
TGU: 
100230017(SLC46A1)
GFR: 
102037163(SLC46A1)
FAB: 
101822270(SLC46A1)
PHI: 
102112748(SLC46A1)
CCW: 
104691199(SLC46A1)
FPG: 
101917306(SLC46A1)
FCH: 
102060198(SLC46A1)
CLV: 
102094714(SLC46A1)
AAM: 
106484311(SLC46A1)
ASN: 
102369417(SLC46A1)
AMJ: 
102576403(SLC46A1)
PSS: 
102452880(SLC46A1)
CMY: 
102943040(SLC46A1)
CPIC: 
101933711(SLC46A1)
ACS: 
100564942(slc46a1)
PBI: 
103059612(SLC46A1)
GJA: 
107119418(SLC46A1)
XLA: 
446819(slc46a1.L)
XTR: 
100145771(slc46a1)
DRE: 
393255(slc46a1)
IPU: 
108278182(slc46a1)
TRU: 
LCO: 
104922850(slc46a1)
MZE: 
101480629(slc46a1)
OLA: 
101170694(slc46a1)
XMA: 
102230721(slc46a1)
SASA: 
106612857(slc46a1)
LCM: 
CMK: 
103180585(slc46a1)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG30344(CG30344) Dmel_CG30345(CG30345)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10638(Dsim_GD10638) Dsimw501_GD10640(Dsim_GD10640)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
727496(GB16239)
BIM: 
BTER: 
NVI: 
TCA: 
API: 
PHU: 
ISC: 
BMY: 
SMM: 
NVE: 
HMG: 
TAD: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID
  Title
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
  Journal
Cell 127:917-28 (2006)
DOI:10.1016/j.cell.2006.09.041
  Sequence
[hsa:113235]
Reference
  Authors
Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H
  Title
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
  Journal
J Pharmacol Exp Ther 322:469-76 (2007)
DOI:10.1124/jpet.107.122606
  Sequence
[hsa:113235]

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