KEGG   ORTHOLOGY: K15909Help
Entry
K15909                      KO                                     

Name
SHIP2, INPPL1
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Pathway
ko00562  Inositol phosphate metabolism
ko04070  Phosphatidylinositol signaling system
ko04662  B cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04910  Insulin signaling pathway
Disease
H01828  Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 Organismal Systems
  Immune system
   04662 B cell receptor signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
   04666 Fc gamma R-mediated phagocytosis
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
  Endocrine system
   04910 Insulin signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
BRITE hierarchy
Other DBs
RN: R09827
GO: 0034485
Genes
HSA: 3636(INPPL1)
PTR: 451403(INPPL1)
PPS: 100992766(INPPL1)
GGO: 101127569(INPPL1)
PON: 100450015(INPPL1)
NLE: 100596562(INPPL1)
MCC: 718421(INPPL1)
MCF: 102115401(INPPL1)
CSAB: 103247996(INPPL1)
RRO: 104665152(INPPL1)
RBB: 108543771(INPPL1)
CJC: 100396447(INPPL1)
SBQ: 101029956(INPPL1)
MMU: 16332(Inppl1)
RNO: 65038(Inppl1)
CGE: 100772102(Inppl1)
NGI: 103750804(Inppl1)
HGL: 101698814(Inppl1)
CCAN: 109693012(Inppl1)
OCU: 100339369(INPPL1)
TUP: 102485077(INPPL1)
CFA: 485209(INPPL1)
AML: 100482460(INPPL1)
UMR: 103678107(INPPL1)
ORO: 101366414(INPPL1)
FCA: 101095611(INPPL1)
PTG: 102956183(INPPL1)
AJU: 106970927(INPPL1)
BTA: 783833(INPPL1)
BOM: 102278222(INPPL1)
BIU: 109569627(INPPL1)
PHD: 102326290(INPPL1)
CHX: 102178924(INPPL1)
OAS: 101121707(INPPL1)
SSC: 100462718(INPPL1)
CFR: 102509164(INPPL1)
CDK: 105096747(INPPL1)
BACU: 102999607(INPPL1)
LVE: 103078405(INPPL1)
OOR: 101269414(INPPL1)
ECB: 100066037(INPPL1)
EPZ: 103549328(INPPL1)
EAI: 106831625(INPPL1)
MYB: 102248134(INPPL1)
MYD: 102755641(INPPL1)
HAI: 109372436(INPPL1)
RSS: 109454033(INPPL1)
PALE: 102890098(INPPL1)
LAV: 100673994(INPPL1)
TMU: 101351608
MDO: 100015500(INPPL1)
SHR: 100930081(INPPL1)
OAA: 100088229
GGA: 428692(INPPL1)
MGP: 100540799
CJO: 107312645
APLA: 101792254
ACYG: 106042953(INPPL1)
TGU: 100222691
GFR: 102032471(INPPL1) 102036900
FAB: 101807549(INPPL1) 101820739
PHI: 102101537 102102439(INPPL1)
PMAJ: 107203647 107212504(INPPL1)
CCW: 104687164(INPPL1) 104691345
FPG: 101918373(INPPL1) 101919963
FCH: 102048151 102056978(INPPL1)
CLV: 102083667(INPPL1) 102085697
EGZ: 104135987
AAM: 106486171(INPPL1)
ASN: 102375443 102388319(INPPL1)
AMJ: 102563685(INPPL1) 102576763
PSS: 102448035(INPPL1) 102448772
CMY: 102929300 102929354(INPPL1)
CPIC: 101932232(INPPL1) 101951468
ACS: 100556812(inppl1)
PVT: 110078090(INPPL1)
PBI: 103051579(INPPL1)
XLA: 108698315 108708768(inppl1.L)
XTR: 100485745(inppl1)
DRE: 325179(inppl1a)
IPU: 108261207(SHIP-2) 108268863(inppl1b) 108277646(inppl1)
TRU: 101065901(inppl1) 101069844
LCO: 104920140(inppl1) 104923483
NCC: 104958004 104968285(inppl1)
MZE: 101483507(inppl1) 101484941
OLA: 101165747(inppl1) 101168299
XMA: 102222770 102228371(inppl1)
PRET: 103471620 103474471(inppl1)
NFU: 107378661 107380469(inppl1)
CSEM: 103378565(inppl1) 103390762
LCF: 108872540 108886606(inppl1)
HCQ: 109516555 109525465(inppl1)
BPEC: 110158855 110174275(inppl1)
ELS: 105029104(inppl1) 105029605
SFM: 108923188 108932224(inppl1)
LCM: 102351582 102361839(INPPL1)
SPU: 584901
APLC: 110981025
CRG: 105320686
MYI: 110463198
OBI: 106880499
LAK: 106158330
EPA: 110241032
ADF: 107355719
HMG: 100212864
AQU: 100641488
SPAR: SPRG_05175
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9660833
  Authors
Habib T, Hejna JA, Moses RE, Decker SJ
  Title
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
  Journal
J Biol Chem 273:18605-9 (1998)
DOI:10.1074/jbc.273.29.18605
  Sequence
[hsa:3636]

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