Semenov M, Tamai K, He X

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

J Biol Chem 280:26770-5 (2005)
DOI:10.1074/jbc.M504308200

Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

Development 135:3801-11 (2008)
DOI:10.1242/dev.025825

Balemans W, Ebeling M, Patel N, Van Hul E, Olson P, Dioszegi M, Lacza C, Wuyts W, Van Den Ende J, Willems P, Paes-Alves AF, Hill S, Bueno M, Ramos FJ, Tacconi P, Dikkers FG, Stratakis C, Lindpaintner K, Vickery B, Foernzler D, Van Hul W

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).

Hum Mol Genet 10:537-43 (2001)
DOI:10.1093/hmg/10.5.537

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