KEGG   ORTHOLOGY: K17690Help
Entry
K17690                      KO                                     

Name
CYP3A5
Definition
cytochrome P450 family 3 subfamily A polypeptide 5 [EC:1.14.14.1]
Pathway
Steroid hormone biosynthesis
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
  Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
   00982 Drug metabolism - cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5
BRITE hierarchy
Other DBs
Genes
HSA: 
1577(CYP3A5)
PTR: 
737374(CYP3A5)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
678692(CYP3A5)
MCF: 
102146134(CYP3A5)
CSAB: 
103246770(CYP3A5)
RRO: 
RBB: 
CJC: 
100404952(CYP3A5)
SBQ: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2732228
  Authors
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.
  Title
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
  Journal
J Biol Chem 264:10388-95 (1989)
  Sequence
[hsa:1577]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

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