KEGG   ORTHOLOGY: K19644
Entry
K19644            Tight     KO                                     
Symbol
dfrA19, dfrA18
Name
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
map00670  One carbon pool by folate
map00790  Folate biosynthesis
map01100  Metabolic pathways
Reaction
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance: KEGG signatures [br01600.html]
 Signature KOs for antimicrobial resistance
  K19644
Other DBs
COG: COG0262
GO: 0004146
Genes
ECLY: LI62_012820
KOK: KONIH1_31170
CFD: CFNIH1_06135
CFQ: C2U38_21260(dfrA)
CFAR: CI104_25730
KIN: AB182_03125
EBC: C2U52_01420(dfrA)
AG: CAC81324(dfrA18)
Reference
PMID:9835490
  Authors
Tosini F, Visca P, Luzzi I, Dionisi AM, Pezzella C, Petrucca A, Carattoli A
  Title
Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.
  Journal
Antimicrob Agents Chemother 42:3053-8 (1998)
DOI:10.1128/AAC.42.12.3053
  Sequence
[ag:CAC81324]

  All links  
Ontology (6)   
   KEGG BRITE (4)   
   GO (1)   
   COG (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
   KEGG RCLASS (3)   
Gene (9)   
   KEGG GENES (8)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (32)   

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