KEGG T05281: BN49

Klebsiella pneumoniae Kp52.145: BN49_1011

Entry

BN49_1011         CDS       T05281

Symbol

cysG1

Name

(GenBank) highly similar to siroheme synthase 1 from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TD45)

K02302

uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]

Organism

kpnk Klebsiella pneumoniae Kp52.145

Pathway

kpnk00860

Porphyrin metabolism

kpnk01100

Metabolic pathways

kpnk01110

Biosynthesis of secondary metabolites

kpnk01120

Microbial metabolism in diverse environments

kpnk01240

Biosynthesis of cofactors

Module

kpnk_M00846

Siroheme biosynthesis, glutamyl-tRNA => siroheme

kpnk_M00924

Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide

Brite

KEGG Orthology (KO) [BR:kpnk00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    BN49_1011 (cysG1)
Enzymes [BR:kpnk01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     BN49_1011 (cysG1)
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     BN49_1011 (cysG1)
4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     BN49_1011 (cysG1)

SSDB

Motif

Pfam:

TP_methylase NAD_binding_7 CysG_dimeriser Sirohm_synth_M Shikimate_DH LSDAT_prok

Other DBs

NCBI-ProteinID:

CDO12772

Position

1049996..1051411

AA seq 471 aa
MDYLPLFAELKQRPVLVIGGGEIAERKIKFLLRAQAQVQVVAETLSPALADLAARQALSW
RATEFSDSLVDDVFLVIAATEDEALNQRVFAAANARYRLVNVVDNQALCSFVFPSIVDRS
PLLVAISSSGKAPVLSRILREKIEALLPTNLGRLAESASYWRNHLKTRLTTTEARRRFWE
RVFTGRFASLMVAGNSAEAEKALQDELDKPERETGEIILVGAGPGDAGLLTLRGLQVIQQ
ADVVFHDHLVTQPVLELVRRDAELICVGKRAGEHSVPQHETNQLLVEAAKAGKTVVRLKG
GDPFIFGRGAEELQAAAEAGIPFQVVPGVTAAAGATAYAGIPLTHRDYAQSAVFVTGHYK
PDSAPFDWSLLAKSQQTLAIYMGTMKAAEISAQLIAHGRDSDTPVAVISRGTRDDQQTIT
GTLQQLEHLAKDAPMPALLVVGEVVQLHQQLAWFQHTSSAEGFNASVVNLA

NT seq 1416 nt +upstreamnt +downstreamnt
gtggattacttgcccctttttgccgaactgaaacaaaggcccgtgctggtgatcggcggc
ggcgagattgctgaacgtaagatcaagttcctgctgcgcgcccaggcgcaggtgcaggtg
gtcgctgaaacgctgtcaccggcgctggccgatctggctgcgcgccaggcactcagctgg
cgggcgacggaattcagcgactcgctggtggatgatgtctttctggtgattgcggccacc
gaggatgaggcgcttaaccagcgggtgtttgcggcagctaacgcgcgctaccggttggtc
aacgtggtggataaccaggcgctgtgctcgtttgttttcccttctatcgtcgaccgttcg
ccgctgctggtggcgatctcctccagcggtaaagcgccggtgctgtcgcgcattctgcgt
gaaaaaatcgaagcgctgctgccgacgaatctcggtcggctggcggaatcagcaagctac
tggcgcaaccatctgaaaacccgcctgacgaccaccgaagcgcgtcgccgcttctgggag
cgcgtctttaccggccgcttcgccagcctgatggtggcgggcaactctgcggaggcggaa
aaagcgctgcaggatgagctcgacaaacccgaacgcgagacgggagaaattattctggtc
ggcgccgggccgggcgatgccgggctgctgacccttcgaggtctgcaggtgatccagcag
gcggacgtggttttccacgatcatctggtgactcagccggttctcgagctggtgcgccgc
gatgccgagctgatctgcgttggcaaacgcgccggcgagcattcggtgccgcagcatgaa
accaatcagctgctggtggaggcggcgaaggcggggaaaaccgtcgtgcgtctgaagggc
ggcgatccgtttatttttggccgcggcgcagaagagctgcaggctgccgccgaggcgggg
atcccgttccaggtggtgccgggcgtcaccgccgccgccggagcgacagcctacgccggt
attccgctgacccatcgcgattatgcgcaaagcgccgtctttgtcaccggccactataag
ccggacagcgcccccttcgactggtcgctgctggcgaagagccaacaaacgctggcgatc
tacatgggcaccatgaaggcagcggaaatcagcgcccagctgatcgcccacggtcgcgac
agcgacacgccggtggcggtaatttcccgcggcacccgtgacgatcagcagacgataacc
ggcacattgcaacaactcgaacacctggcgaaagacgccccgatgcccgccctgctggtg
gtaggcgaagtggtgcagctgcatcagcagctcgcctggtttcaacatacatcatccgcc
gaggggtttaacgcttcggtggtcaatctggcttaa

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