KEGG   Loxodonta africana (African savanna elephant): 100668116Help
Entry
100668116         CDS       T04351                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:lav00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100668116 (INSR)
   04015 Rap1 signaling pathway
    100668116 (INSR)
   04010 MAPK signaling pathway
    100668116 (INSR)
   04066 HIF-1 signaling pathway
    100668116 (INSR)
   04068 FoxO signaling pathway
    100668116 (INSR)
   04072 Phospholipase D signaling pathway
    100668116 (INSR)
   04022 cGMP - PKG signaling pathway
    100668116 (INSR)
   04151 PI3K-Akt signaling pathway
    100668116 (INSR)
   04152 AMPK signaling pathway
    100668116 (INSR)
   04150 mTOR signaling pathway
    100668116 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    100668116 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100668116 (INSR)
   04923 Regulation of lipolysis in adipocyte
    100668116 (INSR)
   04913 Ovarian Steroidogenesis
    100668116 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100668116 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    100668116 (INSR)
   04213 Longevity regulating pathway - multiple species
    100668116 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100668116 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100668116 (INSR)
   04931 Insulin resistance
    100668116 (INSR)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100668116 (INSR)
Protein kinases [BR:lav01001]
 Tyrosine protein kinases
  InsR family [OT]
   100668116 (INSR)
Enzyme-linked receptors [BR:lav01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   100668116 (INSR)
Cytokine receptors [BR:lav04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   100668116 (INSR)
CD molecules [BR:lav04090]
 Proteins
  100668116 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1350 aa AA seqDB search
MWRVCLPVLFSLPVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNIT
RGAVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATV
INGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSEPDDPTKCVACRNFYL
DGRCVETCPPLYYHFQDWRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYT
MNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAE
LEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGESLEVGNYSFYALDNQNLRQLWD
WSKHNLTITRGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAVKTNGDQASCENELL
KFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD
IDPPQRSNDPKSQPHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDAT
NPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKL
PSRTWSPPFESEESQKHNQSDYEESASDCCACPKTDSQILKELEESSFRKTFEDYLHNVV
FVPRPSRKRRALGDVGNVTVAVPTIPGFPNVSSTRVPTSPAEHRPFEKVVNKESLVISGL
RHFTGYRIEVQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQ
EPKEPNGLIVLYEVSYRRYGDEELHLCVXRRHFARERGCRLRGLPPGNYSCACGATSLAG
NGSWTEATHFYVTDYLDVPSNIAKIIIGPLIFVFLVSVVIGSIYLFLRKRQPDGPLGPLY
ASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAET
HVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLK
SYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT
VKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSL
AEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTSLMQMCWQFNPKMRPTFLEIVDLLKD
DLHPSFPEVSFFHSEENKAPESEELEMEFEDMENIPLDQSSHSQRDEARGRDGGSSLSLK
RNYDEHIPYTHMNGGKKNGRILPLPRSNPS
NT seq 4053 nt NT seq  +upstreamnt  +downstreamnt
atgtggcgtgtttgcttacctgtcctgttttctcttccagtgtgtcctggcatggatatt
cggaacaacctcacccggctgcacgagctggagaactgttctgtcattgaaggacatttg
cagatattgttgatgtttaaaacgaggcccgaagatttccgagacctcagtttccccaaa
ctcatcatgatcactgactacttgttgctcttccgggtctatgggctcgagagcctcaag
gacctgttccccaacctcacagtcatccggggctcacgcctcttcttcaactatgcgctg
gtcattttcgagatggtgcacctgaaggagcttggcctctacaacctgatgaatatcacc
cggggggctgtccgcatcgagaagaacaatgagctgtgctacctggccaccattgactgg
tcacgcatcctggactctgtggaggataattacatcgtgctgaacaaagacgacaatgaa
gagtgcggggacatctgtccgggcactgccaagggcaagaccaactgcccagccactgtc
atcaatgggcagtttgttgagcggtgttggacccatagccactgccagaaagtttgcccg
accatctgtaagtctcacggctgcaccgctgaaggcctgtgctgccacagtgagtgtctg
ggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg
gacggcaggtgcgtggagacctgcccgcccctctactaccacttccaggactggcgctgc
gtcaacttcagcttctgccaggacctgcacaacaaatgcaagaactcacggaggcagggc
tgccaccagtacgtcattcacaacaacaagtgcatccccgagtgtccctctggatacacg
atgaactccagcaacctcatgtgcaccccatgcttgggcccctgccccaaggtttgccac
ctcctggagggcgagaagaccatcgactcggtgacgtctgcccaggagctccgggggtgc
accgtggtcaacgggagcctgatcatcaacatccgaggaggcaacaacctggcagctgag
ctagaggccaacctaggtctcattgaagagatttcagggtatctcaaaattcgccgatcc
tacgctctcgtgtcactttccttcttccggaagttacgtctgattcgaggagagagccta
gaagtcgggaactactccttctacgccttggacaatcagaacctaaggcagctatgggac
tggagcaaacacaacctcaccatcactcgggggaaactcttcttccactataaccccaag
ctttgcttgtcagaaattcataagatggaggaagtttcgggaaccaaggggcgccaggaa
agaaacgacattgccgtgaagaccaatggggatcaggcatcctgtgaaaatgaattactt
aaattttcttacatccggacatcttttgacaagatcttgctcaggtgggagccatattgg
ccccccgacttccgagacctcctggggttcatgcttttctataaagaggccccctatcag
aatgtgacagaatttgacgggcaggatgcctgtggttccaacagctggacggtggtggac
attgacccgccccagaggtccaacgaccccaagtcacagccccaccctgggtggctgatg
cggggcctcaagccctggactcagtacgccatctttgtcaagaccttggtcaccttttct
gatgagcgccggacctatggggccaagagtgacatcatctatgtccagacagatgctacc
aatccttccgtccctctggatccaatctcagtttctaattcctcatcccagattattttg
aagtggaaacccccttcggaccccaacggcaacatcactcactacctggttttctgggag
aggcaggcggaagacagtgagctgtatgagttggattattgcctcaaagggttgaagctg
ccctcccggacctggtctccaccgttcgagtctgaagagtcccagaaacacaaccagagt
gactatgaagagtcagccagcgactgctgtgcctgtcccaagaccgactctcagatcctc
aaggagctggaggagtcctcgttccgcaagacattcgaggattacctgcacaatgtggtt
ttcgtccccaggccatcgcggaaacgcagggcccttggcgatgttgggaacgtgacagtg
gccgtgcccacgattccaggtttccccaatgtctcctcaaccagagtgcccactagcccg
gcagagcaccggcccttcgagaaagtggtaaacaaggagtcgctggtcatttctggcctg
cgtcatttcactggctatcgcatcgaagtgcaggcttgcaaccaagatgccccagaggaa
aggtgtagcgtggcagcctacgtcagcgccagaactatgcccgaagccaaggctgacgac
atcgttggtccagtgacccatgaaatcttcgagaacaatgtcgtccacttgatgtggcag
gagccaaaggaacccaatggtctgattgtgctgtacgaagtgagttatcggcgatatggc
gatgaggagctgcacctttgcgtcntccgtaggcattttgcccgggagcggggctgccgg
ctgcgagggctgcccccaggcaactacagctgcgcgtgcggggccacctccctggcgggc
aatggctcctggaccgaagccacccatttctacgtaacagactacttggacgtcccatca
aatattgcaaaaatcatcattggcccactcatctttgtctttctcgtcagtgttgtgatt
gggagtatttatctattcctgagaaagaggcagccggacggtccattgggaccgctgtat
gcttcttcaaaccctgagtacctcagtgccagcgatgtgtttccctgctctgtctacgtg
cctgacgagtgggaggtaccccgcgagaagatcaccctcctgcgtgagctgggccagggc
tccttcggcatggtgtacgagggcaatgccagggacattgtcaagggcgaggcggagacc
cacgtggcagtgaagacagtcaacgagtcagccagcctgcgagagcggatcgagttcctc
aatgaggcctctgtcatgaagggtttcacctgccaccacgtggtccgcctcctgggggtg
gtgtccaaaggtcagccgacgctggtggtgatggagttgatggctcacggggacctgaag
agctacctccgttcgctgcggccagaggctgagaacaatcccggccgccctccccccacc
ctgcaagagatgattcagatggcagctgagattgcagatgggatggcatacctgaatgcc
aagaagtttgtgcaccgggacctcgcagctcgcaactgcatggtggcccacgatttcacc
gtcaaaattggagactttggaatgaccagagacatctatgaaacggattactaccggaaa
ggggggaagggcctgctccctgtgcggtggatggccccggaatcgctcaaggatggtgtc
tttaccacgtcttctgacatgtggtcctttggtgtggtcctttgggaaatcaccagcttg
gcggagcagccttaccaaggcctgtctaacgagcaggtgttgaaatttgtcatggatggg
gggtatctggatcaacctgacaactgtccagagagagtcaccagcctgatgcaaatgtgc
tggcagttcaaccccaagatgcggccgaccttcctggagattgtcgacctgctcaaggac
gaccttcaccctagctttccggaagtttccttcttccacagcgaggaaaacaaggctccc
gagagtgaggagctggagatggagtttgaggacatggagaacatccccctggatcagtcc
tcgcactctcagagggacgaggccaggggccgggacggcgggtcctcgctgagcctaaag
cggaactacgacgagcacatcccctacacccacatgaacgggggcaagaagaacgggcgg
attctgcctctgcccaggtcgaatccttcctaa

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