KEGG   Loxodonta africana (African savanna elephant): 100677444
Entry
100677444         CDS       T04351                                 
Symbol
PLCE1
Name
(RefSeq) LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00562  Inositol phosphate metabolism
lav01100  Metabolic pathways
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04024  cAMP signaling pathway
lav04070  Phosphatidylinositol signaling system
lav04919  Thyroid hormone signaling pathway
lav04933  AGE-RAGE signaling pathway in diabetic complications
lav05205  Proteoglycans in cancer
Module
lav_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100677444 (PLCE1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100677444 (PLCE1)
   04015 Rap1 signaling pathway
    100677444 (PLCE1)
   04020 Calcium signaling pathway
    100677444 (PLCE1)
   04070 Phosphatidylinositol signaling system
    100677444 (PLCE1)
   04024 cAMP signaling pathway
    100677444 (PLCE1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    100677444 (PLCE1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100677444 (PLCE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100677444 (PLCE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lav04131]
    100677444 (PLCE1)
Enzymes [BR:lav01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100677444 (PLCE1)
Membrane trafficking [BR:lav04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100677444 (PLCE1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100677444 (PLCE1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 100677444
NCBI-ProteinID: XP_023402682
Position
Unknown
AA seq 1995 aa
MVSEGSAAGRSFAGMEEVRQHHLRFCRGIKIWHWAWFLCSLLGREPQEREAGCQLGLCTL
SACLEGWLSSPISAVPKFALVNEGCRCXRLKDDQIYNPVRRGEEIEDTIGSLIHFFRKLP
ASEITHGRISSGPCLKQCVQDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTF
GGSTGRMMLKERQPGTSMANSNALPSSTAGISKELIDLQPLIQFPEEVASILMEQEQNIY
RRVLPVDYLCFLTRDLGTSECQRSLPCLKASISASILTSQYGEHNTLEDLVMRFNEVSSW
VTWLILAAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSD
IETMRSLKDAMAQHESSCEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLC
PRYNSQEETLEFVADYNGQDNFLQRVGQNGLKNSEKESTVNSIFQIIRSCSRSLEAEEES
SPSEGNSSRKNSLKDKTRWQFIIGDLLDSENDTFEQSKEWDPHGAEEPLKAFDHGTELIP
WYVLSIRADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWIKPITASPASAKAK
FGVLSNTVEPGKFPLLGSAGVSGLAEGVLDLFSAKAVYMGHPGIDIHTVCVQNKLDSMLL
SETGVTLLYGLQTTDNRLLHFVAPKHTARMLFSGLLALTRAVRKMRRFPDQRLQWLRKQY
VSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSAEKPNMQRNNTLGISTTKKK
KKILMRGESGEVTDDEMATRKAKTYKECRSRSGSDPQDINEQEESETNAITSPPNLLPSR
RAHSLTTAGSPSLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMQGFQNFM
VSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCSRLSSESAPLYTNLTIEENTSGL
QPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGIL
QLNDFLVNCQGEHCTYDEILSIIQKFEPNVSMCHQGLMSFEGFARFLMDKDNFASKNDES
QENVKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGM
PIIYHGHTLTTKIPFKEVVEAINRSAFVNSDLPIIISIENHCSLPQQRKMAEIFKTVFGE
KLVAKFLFESDFSDDPMLPSADQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAY
NGGNANPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRI
KKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNAPG
SSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSFEGIRQTWEESSSPLNSTTSLSA
IIRTPRCYHISSLNENAAKRLCRRYSQKLIQHTTCQLLRAYPAATRIDSSNPNPLMFWLH
GIQLVALNYQTEDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLENME
PAIYALTIVSGQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFR
VHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRR
MEENSSSSTIPASLMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLHQIWT
TEQGTKPITTDYFLMEEKYFIPKEKHECRKQPFQRAIGPEEEIVQVLSSWFPEEGYVGRI
VLKTQQQEVKEKSIVQDDREVTFSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQ
TLCKAKYSYSILSNPNPSDYVLMEEVVKDPANKKSSTPKSSQRVLSDQECVFQAQSKWKG
AGKFILKLKEQVQASREDKRKGISFASELKKLTKSTKQPRGLTSPSQLSASESVPSKEEK
PMGSFASSDVMDCRQ
NT seq 5988 nt   +upstreamnt  +downstreamnt
atggtttcagaaggaagtgcagcaggaagaagcttcgcaggaatggaagaggtgcggcag
caccatctgagattctgcagagggattaagatttggcactgggcttggtttctgtgcagc
ctcttaggcagagagcctcaggagagggaagcaggctgtcagctggggctttgcacactc
tcagcctgccttgagggttggttgtcttcccccatctctgcagtacccaagtttgcattg
gtaaacgaaggatgcagatgctagaggcttaaagacgaccagatctacaatccagtaaga
cgaggagaagaaatagaagatacaattggatctcttatccatttcttcagaaagctccca
gcctctgaaataacccatggaaggattagcagtggtccatgcttaaagcaatgtgtccaa
gacactgtatgtgagtatcgcgccaccctccaaaggacttccatatctcagtacatcacc
gggtctctcctagaagcaaccacatctttaggagcaagaagtggccttctcagtactttt
ggaggatccactggacgaatgatgctgaaagagcgccaaccaggcacctccatggctaat
tccaatgccctcccttcaagtacagctgggatcagcaaggaactgattgatctgcagcct
ctcatccagttcccagaggaagttgccagcatcctgatggagcaggagcagaatatttac
cgaagggtcttgccggttgactacctttgcttcttaacccgggacttaggtacttccgaa
tgccagaggtccctgccctgcctcaaagcatccatctcagcatcaattcttacatcccag
tatggagagcacaatacccttgaagatcttgtgatgagatttaatgaggtgagctcctgg
gtgacgtggctgatcctcgcggcaggctccatggaggagaagcgggaagtcttttcgtat
ttggtgcatgtggccaaatgctgctggaacatgggcaactacaacgctgtcatggagttc
ttggctggcctcaggtcaagaaaagtcctaaaaatgtggcagtttatggaccagtctgac
attgagaccatgaggagcctgaaggatgccatggctcagcacgaatcatcctgcgagtac
aagaaggtggtgacccgggcgttgcacattcctggctgtaaggtggttccattctgtggg
gtgtttctgaaggagctctgcgaagtccttgatggagcctctggcctcatgaagctttgc
ccacgatacaactcccaagaagagactttagagtttgtagcggattacaatggacaagat
aatttcttacaacgagtgggacaaaatggcttaaagaattcagagaaggagtccaccgtc
aatagcatctttcagattatcaggagctgcagtcgaagcctggaggcggaggaggaaagc
agccccagtgaaggaaacagctccaggaaaaattccttgaaggataaaactcggtggcag
tttataattggagatctgttggattcagaaaatgacacctttgagcagtccaaagaatgg
gacccacatggagcagaagagccactgaaggccttcgaccacggcacggagctcatcccc
tggtatgtgctgtccatccgagctgacgtgcaccagttcctgctacagggagccacagtc
atccactatgaccaggacacgcacctctctgcccgctgcttcctccagcttcagcctgac
aatagcaccttgacctggataaagcccatcactgcctccccagccagcgctaaagccaaa
tttggtgtgcttagtaatacagtcgaacctggcaaattcccgttactgggcagtgctgga
gtaagcggactggcagagggagtcttggatttgttttcagccaaagctgtgtacatggga
cacccgggcattgatatacacactgtgtgtgttcagaacaaactggatagcatgcttctc
tcagagactggtgtgacgctgctgtatggacttcagaccacggacaatagattattgcac
tttgtggcaccaaagcacacagccagaatgctcttcagcggattgttggcactcactaga
gctgtgagaaagatgaggaggttccctgaccagagactgcagtggctgcggaaacagtac
gtcagcctctatcaggaggatggacgatatgaaggcccaactttggctcacgctgtggag
ttgtttggaggcagacgatggagtactcgaaatcccagccctgggacatcagccaagagt
gctgagaagcccaacatgcagagaaacaacaccctgggcataagcaccaccaagaaaaag
aagaaaattctcatgaggggtgagagtggagaggtaactgacgatgagatggcaaccagg
aaggccaaaacgtacaaggagtgtcgaagccggagtggttctgatcctcaagatattaat
gaacaagaagaatcagagacaaatgccatcaccagccctcctaaccttctcccttccaga
agagcccactctttgaccacggctgggtcccctagcttggctgccgggacatcatctccc
atcaggccagtgtcctcccctgtgctgtcttcttcaaacaagagcccgtccagtgcttgg
agcagcagcagctggcacgggcggatcaaaggaggaatgcagggcttccagaacttcatg
gtttcagacagtaacatgagttttgttgaattcgttgagctgtttaaatcattcagtgta
aggagccggaaggacctcaaggatctttttgatgtctacgcggtaccctgcagccgattg
agctccgaatctgccccgctctacaccaacttgacaattgaggaaaacaccagtggtctt
cagcctgacttagatttgttgaccagaaatgtctcggatttggggttgttcattaaaagt
aaacaacagctttcagacaaccagaggcagatatctgatgccatcgcagctgcaagtatt
gtgacaaatgggactgggattgagagcacgtccctgggcatatttggagttggcatactc
cagctcaatgacttcctagtgaattgccaaggagaacactgcacttatgatgaaatcctc
agcatcattcagaaatttgagcctaacgttagtatgtgtcaccagggcctaatgtcattt
gagggattcgcaaggttcctgatggataaagataattttgcctcaaaaaatgatgagtca
caggagaatgttaaagaattgcagctacccctctcctactactacattgaatcttcacac
aatacctacctcacaggccatcagctcaaaggagagtcctcagtagaactctacagccag
gttcttctgcaaggctgtaggagcgtggagttggactgctgggatggagatgatgggatg
ccaatcatttatcatggacatacactgacaaccaagatccccttcaaggaagtggtcgaa
gccatcaatcgcagcgccttcgtcaactctgacctgccaatcatcatatcgattgagaac
cactgttcattgcctcagcaacggaaaatggcagaaatcttcaagactgtgtttggagaa
aagctggtggctaaattcttatttgagagtgatttctcagatgatccaatgcttccctca
gctgaccaactaaggaggaaagtcctcctcaaaaacaagaagctaaaagcccaccagaca
ccagtggatattttaaagcaaaaggctcatcagttagcgtccatgcaagctcaggcttat
aatggtgggaatgccaatcctccacctgctaataatgaggaagaggaggacgaagaggat
gaatatgactatgactatgagtccctctctgatgacaacattctggaagacagacctgaa
aataaatcatgtaatgacaagcttcagtttgagtataatgaagaaatccctaagaggata
aagaaagcagataactctgcttgcaacaaaggaaaggtttatgacatggagctgggtgaa
gaattttaccttcctcagaacaaaaaggaaagccgacagattgcaccagagctttctgac
cttgtcatctattgccaagcagtaaaatttccaggcctgtcaactctaaatgcacctggc
tctagcagaggaaaagaaaggaaaagcaggaagtccatttttggcaataatccgggcaga
atgagcccaggggagacagcatcctttaacaaaacatctggaaaaagttctttcgaagga
atacgccagacctgggaagaatcgtcttcccctcttaactcaaccacatccctcagcgca
atcattagaactcccagatgttatcatatctcgtcgctgaatgaaaatgctgccaagcgt
ctgtgtcgcaggtattctcagaaactgatccagcacaccacctgccagctgctgagggca
taccccgctgccacccgcattgactcttccaaccccaaccctctcatgttctggcttcat
gggatccagctcgttgcactgaactaccaaacagaagatctccctttacatttaaatgct
gcaatgtttgaggctaacggtggctgtggttatgttttgaaacctccagttctgtgggac
aagaactgtcccatgtatcagaagttttctccattggaacgtgacctggaaaacatggag
cctgccatctatgctttaactattgtctctggtcaaaatgtgtgccctagcaacagcaca
ggaagcccatgtattgaagttgacgtcctgggcatgcccctagacagctgccatttccgc
acgaagcccatccaccgaaacactctgaaccccatgtggaatgagcagtttctcttccga
gttcactttgaagatcttgtatttcttcgttttgcagtggtggaaaacaacagctcggca
gtaactgctcagagaatcattccactcaaggccttaaaacgaggatatcgacaccttcag
ctccgaaacctccacaatgaagtcttggaaatttccagtttattcataaacagcagaagg
atggaagaaaattcctccagcagtaccataccagcctctttgatgtttaatacagaagaa
agaaaatgtttgcagacacacagagtcacagtgcacggggtcccaggtccagagcccttt
accgttttcactataaatggaggcaccaaggcaaagcagcttctccaccaaatttggacg
actgagcaaggcaccaaacctatcactacagactattttttgatggaagaaaagtatttt
atacctaaagaaaagcatgaatgcaggaaacagccgttccagagagccattggtcccgaa
gaagagatcgtgcaggttttaagcagctggtttccagaagagggatacgttggcaggatt
gtcttaaaaacccagcagcaggaagtaaaagagaaaagcattgttcaagacgacagagag
gtgaccttcagctcagaggaggagagtttctttgtgcaagtgcacgatgtttctcccgag
caaccccgaactgtcatcaaagcgccccgtgtcagcactgcacaggacgtcattcagcag
accctatgcaaagccaaatattcctacagcattctgagcaaccccaacccaagtgactat
gtactaatggaagaggtggtgaaagaccctgccaacaagaagtcttctaccccaaagtcc
tcccagcgggtcctttcggatcaggagtgtgtgttccaagcccaaagcaagtggaaaggt
gcaggaaaattcatccttaagctaaaggagcaagtgcaggcatcccgagaagataaaagg
aaaggcatttcgtttgcaagtgaactcaagaagctcaccaagtcaacgaaacagccacga
ggacttacatcaccatctcaactctcagcctcagaaagtgtcccaagcaaggaggaaaaa
cctatgggcagcttcgcctcaagtgatgtgatggactgtcggcagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (11)   
   KEGG PATHWAY (10)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (63)   

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