| Entry |
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| Definition |
dihydrofolate reductase-thymidylate synthase
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| Orthology |
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| Organism |
lbz Leishmania braziliensis
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| Pathway |
| Pyrimidine metabolism | | One carbon pool by folate | | Folate biosynthesis | | Metabolic pathways |
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| Brite |
KEGG Orthology (KO) [BR:lbz00001]
Metabolism
Nucleotide metabolism
00240 Pyrimidine metabolism
LBRM_06_0830
Metabolism of cofactors and vitamins
00790 Folate biosynthesis
LBRM_06_0830
00670 One carbon pool by folate
LBRM_06_0830
Enzymes [BR:lbz01000]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
LBRM_06_0830
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
LBRM_06_0830
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| SSDB |
    |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: UniProt: |
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| Position |
6:356269..357834
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| AA seq |
521 aa  
MSRAAARFKIPMSVTKDSFAFPSLRCFSIIVAVDEQHGIGDGKTIPWQVPEDMAFFKDQT
TLLRNKKPPTEKKRNAVVMGRQTWESVPLKYRPLKGRLNVVLSSKATVDELLAALPEGKR
TAAAQDLVVVNGGLAEALHLLARPPHCSSIETAYCVGGAQVYSDAMTAPCVEKLQEVYLT
RIYATAPECTRFYPFPPTNAAAAAWDLAWTQGRQRSETGGVEYEIRKYVPHNHEERQYLE
LIDRIMKTGIAKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRG
ETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYKGFEANYD
GEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDAKELSCML
YQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERT
PNAFPTLVFKREREFLEDYELSDMEVIDYAPYPPIKMEMAV |
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| NT seq |
1566 nt  +upstreamnt +downstreamnt
atgtccagggcagctgcgaggtttaagatcccgatgtcggtgacgaaggacagctttgcc
ttcccctcccttcgctgcttctccatcattgtcgccgttgatgagcagcacggcatcggc
gacggaaagacaatcccgtggcaggtgccggaggacatggcgttcttcaaagaccaaacc
acgctgctacgcaacaagaaaccgccgacggagaagaagcgcaacgccgtcgtgatgggt
cgccagacgtgggaaagcgttccgctcaagtaccggccactcaagggtcggctgaacgtg
gtgctttcctcgaaggccaccgtggacgagcttctggcggcactgccggagggaaagcgg
accgcagcggcgcaggatctggtggtggtgaacggcggactcgccgaggcactccatctc
ctcgcacggccgccgcactgcagctccattgaaacagcgtactgcgtcggtggcgcgcag
gtttactccgacgccatgacggcgccgtgcgtcgagaagctgcaggaggtgtacctgacc
cgcatctacgcgacggcgccggagtgtacgcgcttctacccgttcccgcccacaaacgcc
gccgccgccgcgtgggacctggcatggactcagggacgccagcggagcgagactggcggt
gtcgagtacgagatccgaaaatacgtgccacacaaccacgaggagcggcagtacctcgaa
ctgattgaccgcatcatgaagactggtattgcgaaggaggaccgcaccggagtgggcatt
ctcagcctcttcggcgcgcagatgcgcttctccttgcgagacaaccgcctgccgctcttg
acaacgaagcgtgttttctggcgcggcgtgtgcgaggagctgctgtggttcctgcgcggc
gaaacaaacgcccagttgctggcggacaaggacattcacatctgggatggtaacggctcg
cgcgagtttctcgacagccgcggcttgacggcgaataaggagatggatctcggccctgtc
tacggattccagtggcgccacttcggagcacagtacaaggggtttgaggcgaattacgat
ggcgaaggggtggaccagatcaaatccatcgtggagaccatcaaggtgaacccaaacgac
cgccgcctcctgttaactgcctggaacccatgcgcgctgcacgagatggcgttgccgccc
tgtcacttgcttgctcagttctacgtgaacacggacgcgaaggagctgtcctgcatgctg
taccagcgctcgtgcgacatggggctcggcgtccccttcaacatcgcctcctacgcgctg
ctcaccatccttatggcaaaagccacgggtctgcggcctggcgaactcgtgcacacgctc
ggcgacgcccatgtctatcgcaaccacatcgatgctctgaaagtgcagctcgagcgaacc
ccgaacgccttcccgaccctcgtgttcaagagggaacgggagttcctggaggactacgag
ttgtcagacatggaggtgatcgactacgcgccatacccgcctattaagatggagatggcc
gtatag |
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