KEGG   Leishmania infantum: LINJ_06_0890Help
Entry
LINJ_06_0890      CDS       T01112                                 

Gene name
DHFR-TS
Definition
dihydrofolate reductase-thymidylate synthase (EC:1.5.1.3 2.1.1.45)
Orthology
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
lif  Leishmania infantum
Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Brite
KEGG Orthology (KO) [BR:lif00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    LINJ_06_0890 (DHFR-TS)
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    LINJ_06_0890 (DHFR-TS)
   00670 One carbon pool by folate
    LINJ_06_0890 (DHFR-TS)
Enzymes [BR:lif01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     LINJ_06_0890 (DHFR-TS)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     LINJ_06_0890 (DHFR-TS)
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
6:379824..381386
Genome map
AA seq 520 aa AA seqDB search
MSRAAARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKR
AAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLT
RIYTTAPACTRFFPFPPENTTTAWDLASSQGRRKSEADGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVP
HAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV
NT seq 1563 nt NT seq  +upstreamnt  +downstreamnt
atgtccagggcagctgcgaggtttaagattccgatgccggcgacgaaggcggacttcgcc
ttcccctctctgcgcgccttctccatcgttgtggccctcgataagcagcacggcatcggc
gacggcgagtcgatcccgtggcgggtgccggaggacatggcgttcttcaaggaccagacg
acgctgttgcgcaacaaaaagccgccgacggagaagaagcgcaacgctgtcgtgatgggc
cgcaagacgtgggagagcgtcccggtaaagttccgaccactcaagggacggctgaacatt
gtgttgtcctcgaaggccaccgtcgaggagcttctggcgccgctgccggagggaaagcgc
gctgccgcggcgcaggatgtggtggtggtgaacggcggtctggccgaggcgctccgcctc
ctcgcacgcccgccgtactgcagctccatcgagacagcgtattgcgtcgggggtgcgcag
gtttatgcggacgccatgctgtcgccgtgcgtcgagaagctgcaggaggtgtacctgacc
cgcatctacacgacggcgcctgcgtgtacgcgcttctttccgtttccgcccgagaacacc
accacggcgtgggacctggcgtcgtctcagggacgccgcaagagcgaggcggacggcctc
gagttcgagatctgcaagtacgtgccgcgtaaccatgaggagcggcagtaccttgagctg
attgaccgcatcatgaagacggggatcgtgaaggaggaccgcaccggcgtgggcaccatc
agcctcttcggcgcacagatgcgcttctccctacgcgacaaccgcctgccgctgctgacg
acgaagcgtgtcttctggcgcggcgtgtgcgaggagctgctgtggttcctgcgcggggag
acgaacgcgcagctgctggcggacaaggacattcacatctgggacggcaacggctcgcgc
gagtttctcgacagccgcggcttgacagagaataaggagatggacctcggccctgtctac
ggcttccagtggcgccacttcggggcagattacaaggggtttgaagcgaactacgacggc
gaaggggtggaccagatcaggtccatcgtggagacgatcaaggcgaacccgaacgaccgc
cgccttctattcactgcctggaacccgtgcgcgctgcaaaagatggcgctgccgccgtgc
cacttgcttgctcagttctacgtgaacacggacacgagcgagctatcctgcatgctgtac
cagcgctcgtgcgacatgggtctcggcgtccccttcaacatcgcctcctacgcgctgctc
accatcctcattgccaaggcgacgggcctgcggcctggtgagcttgtgcacacccttggt
gacgcccacgtctaccgcaaccacgtcggtgccctcaagtcgcagctcgagcgagtcccg
cacgcgttcccgaccctcgtcttcaaggaggagcgtcagttcctcgaggactacgagtta
acggacatggaggtgatcgactacgttccacacccgccgatcaagatggagatggccgta
tag

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