| Entry |
|
|---|
| Name |
iodide peroxidase;
iodotyrosine deiodase;
iodinase;
iodoperoxidase (heme type);
thyroid peroxidase;
iodide peroxidase-tyrosine iodinase;
iodotyrosine deiodinase;
monoiodotyrosine deiodinase;
thyroperoxidase;
tyrosine iodinase;
TPO |
|---|
| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
 |
|---|
| Sysname |
iodide:hydrogen-peroxide oxidoreductase |
|---|
| Reaction(IUBMB) |
2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810] |
|---|
| Reaction(KEGG) |
R02810;
(other) R03208 R03539 R03953 R03973 R08520 R08521 R08522 R08523
 |
|---|
| Substrate |
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080] |
|---|
| Product |
diiodine;
H2O [CPD:C00001] |
|---|
| Cofactor |
Heme [CPD:C00032] |
|---|
| Comment |
A hemoprotein. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00431 thyroid peroxidase |
|---|
| Genes |
HSA: 7173(TPO)
MCC: 721610(TPO)
MMU: 22018(Tpo)
RNO: 54314(Tpo)
CFA: 403521(TPO)
BTA: 525013(TPO)
ECB: 100072955
MDO: 100032350
OAA: 100080616
GGA: 776120(TPO)
TGU: 100218312
DRE: 569363
BFO: BRAFLDRAFT_67515
CIN: 100183311
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:12325367]
Coval ML, Taurog A.
Purification and iodinating activity of hog thyroid peroxidase.
J. Biol. Chem. 242 (1967) 5510-23.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13718859]
CUNNINGHAM BA, KIRKWOOD S.
Enzyme systems concerned with the synthesis of monoiodotyrosine.
III. Ion requirements of the soluble system.
J. Biol. Chem. 236 (1961) 485-9.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13964156]
HOSOYA T, KONDO Y, UI N.
Peroxidase activity in thyroid gland and partial purification of the
enzyme.
J. Biochem. 52 (1962) 180-9.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13563451]
SERIF GS, KIRKWOOD S.
Enzyme systems concerned with the synthesis of monoiodotyrosine. II.
Further properties of the soluble and mitochondrial systems.
J. Biol. Chem. 233 (1958) 109-15.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.11.1.8
IUBMB Enzyme Nomenclature: 1.11.1.8
ExPASy - ENZYME nomenclature database: 1.11.1.8
BRENDA, the Enzyme Database: 1.11.1.8
CAS: 9031-28-1 |
|---|
