| Entry |
|
|---|
| Name |
cytochrome-c3 hydrogenase;
H2:ferricytochrome c3 oxidoreductase;
cytochrome c3 reductase;
cytochrome hydrogenase;
hydrogenase [ambiguous] |
|---|
| Class |
Oxidoreductases;
Acting on hydrogen as donor;
With a cytochrome as acceptor
 |
|---|
| Sysname |
hydrogen:ferricytochrome-c3 oxidoreductase |
|---|
| Reaction(IUBMB) |
2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3 [RN:R04015] |
|---|
| Reaction(KEGG) |
R04015
 |
|---|
| Substrate |
H2 [CPD:C00282];
ferricytochrome c3 [CPD:C02682] |
|---|
| Product |
H+ [CPD:C00080];
ferrocytochrome c3 [CPD:C02684] |
|---|
| Cofactor |
Iron [CPD:C00023];
Nickel [CPD:C00291];
Iron-sulfur [CPD:C00824] |
|---|
| Comment |
An iron-sulfur protein. Some forms of the enzyme contain nickel
([NiFe]-hydrogenases) and, of these, some contain selenocysteine
([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also
be reduced. |
|---|
| Orthology |
KO: K00437 cytochrome-c3 hydrogenase |
|---|
| Genes |
MCA: MCA2726
AZO: azo1414(hoxY)
DAR: Daro_0981
CNO: NT01CX_0257
PAB: PAB0638(hydB-2) PAB0640(hydD-2) PAB1784
 |
|---|
| Structures |
PDB: 1FRV 1H2R 1UBH 1UBJ 1UBK 1UBL 1UBM 1UBO 1UBR 1UBT
1UBU 1WUH 1WUI 1WUJ 1WUK 1WUL 1YQ9 1YQW 1YRQ 3CUR
3CUS 3H3X |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4364940]
Der Vartanian DV, LeGall J.
A monomolecular electron transfer chain: structure and function of
cytochrome C3.
Biochim. Biophys. Acta. 346 (1974) 79-99.
Desulfovibrio desulfuricans [GN:dde], Desulfovibrio gigas,
Desulfovibrio vulgaris |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3546297]
Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H.
Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki
F.
J. Biol. Chem. 262 (1987) 2823-5.
Desulfovibrio vulgaris [GN:dvm] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13741672]
RIKLIS E, RITTENBERG D.
Some observations on the enzyme, hydrogenase.
J. Biol. Chem. 236 (1961) 2526-9.
Desulfovibrio desulfuricans [GN:dde] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13745271]
SADANA JC, MOREY AV.
Purification and properties of the hydrogenase of Desulfovibrio
desulfuricans.
Biochim. Biophys. Acta. 50 (1961) 153-63.
Desulfovibrio desulfuricans [GN:dde] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:7854413]
Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M,
Fontecilla-Camps JC.
Crystal structure of the nickel-iron hydrogenase from Desulfovibrio
gigas.
Nature. 373 (1995) 580-7.
Desulfovibrio gigas |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:10378275]
Garcin E, Vernede X, Hatchikian EC, Volbeda A, Frey M,
Fontecilla-Camps JC.
The crystal structure of a reduced [NiFeSe] hydrogenase provides an
image of the activated catalytic center.
Structure. 7 (1999) 557-66.
Desulfovibrio gigas |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.12.2.1
IUBMB Enzyme Nomenclature: 1.12.2.1
ExPASy - ENZYME nomenclature database: 1.12.2.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.2.1
BRENDA, the Enzyme Database: 1.12.2.1
CAS: 9027-05-8 |
|---|
