| Entry |
|
|---|
| Name |
lipoxygenase;
lipoxidase;
carotene oxidase;
lipoperoxidase;
fat oxidase;
lipoxydase;
lionoleate:O2 oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
linoleate:oxygen 13-oxidoreductase |
|---|
| Reaction(IUBMB) |
linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
[RN:R03626] |
|---|
| Reaction(KEGG) |
R03626;
(other) R07864 R07869
 |
|---|
| Substrate |
linoleate [CPD:C01595];
O2 [CPD:C00007] |
|---|
| Product |
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate [CPD:C04717] |
|---|
| Cofactor |
Iron [CPD:C00023];
PQQ [CPD:C00113] |
|---|
| Comment |
An iron protein. Also oxidizes other methylene-interrupted
polyunsaturated fatty acids. |
|---|
| Pathway |
PATH: ec00591 Linoleic acid metabolism
PATH: ec00592 alpha-Linolenic acid metabolism
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00454 lipoxygenase |
|---|
| Genes |
ATH: AT1G17420(LOX3) AT1G55020(LOX1) AT1G67560 AT1G72520
AT3G22400(LOX5) AT3G45140(LOX2)
OSA: 4328603(Os02g0194700) 4331824(Os03g0179900)
4333818(Os03g0699700) 4333821(Os03g0700400)
4333823(Os03g0700700) 4334049(Os03g0738600)
4335971(Os04g0447100) 4338358(Os05g0304600)
4345993(Os08g0508800) 4345994(Os08g0509100)
4350766(Os11g0575600) 4352505(Os12g0559200)
4352509(Os12g0560200)
 |
|---|
| Structures |
PDB: 1F8N 1FGM 1FGO 1FGQ 1FGR 1FGT 1HU9 1IK3 1JNQ 1N8Q
1NO3 1ROV 1RRH 1RRL 1Y4K 1YGE 2IUK 2SBL 3BNB 3BNC
3BND 3BNE |
|---|
Reference
Authors
Title
Journal
|
1
Christopher, J., Pistorius, E. and Axelrod, B.
Isolation of an enzyme of soybean lipoxidase.
Biochim. Biophys. Acta 198 (1970) 12-19. |
|---|
Reference
Authors
Title
Journal
|
2
Theorell, H., Holman, R.T. and Akesson, A.
Crystalline lipoxidase.
Acta Chem. Scand. 1 (1947) 571-576. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5447012]
Zimmerman DC, Vick BA.
Specificity of flaxseed lipoxidase.
Lipids. 5 (1970) 392-7.
Glycine max, Linum usitatissimum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.12
IUBMB Enzyme Nomenclature: 1.13.11.12
ExPASy - ENZYME nomenclature database: 1.13.11.12
BRENDA, the Enzyme Database: 1.13.11.12
CAS: 9029-60-1 |
|---|
