| Entry |
|
|---|
| Name |
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
arachidonate:oxygen 12-oxidoreductase |
|---|
| Reaction(IUBMB) |
arachidonate + O2 =
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
[RN:R01596] |
|---|
| Reaction(KEGG) |
R01596
 |
|---|
| Substrate |
arachidonate [CPD:C00219];
O2 [CPD:C00007] |
|---|
| Product |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
[CPD:C05965] |
|---|
| Inhibitor |
3-Methoxytropolone [CPD:C02639] |
|---|
| Comment |
The product is rapidly reduced to the corresponding 12S-hydroxy
compound. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism |
|---|
| Orthology |
KO: K00458 arachidonate 12-lipoxygenase |
|---|
| Genes |
HSA: 239(ALOX12)
PTR: 455242(ALOX12)
MCC: 713683 713748
MMU: 11684(Alox12) 11685(Alox12e) 11687(Alox15)
RNO: 287454(Alox12)
CFA: 479476(ALOX12)
BTA: 407169(ALOX12)
MDO: 100015746
 |
|---|
| Structures |
PDB: 3D3L |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4215079]
Hamberg M, Samuelsson B.
Prostaglandin endoperoxides. Novel transformations of arachidonic
acid in human platelets.
Proc. Natl. Acad. Sci. U. S. A. 71 (1974) 3400-4.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:804329]
Nugteren DH.
Arachidonate lipoxygenase in blood platelets.
Biochim. Biophys. Acta. 380 (1975) 299-307.
Bos taurus [GN:bta], Sus scofa [GN:ssc], Equus caballus [GN:ecb],
Ovis aries |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6783111]
Wallach DP, Brown VR.
A novel preparation of human platelet lipoxygenase. Characteristics
and inhibition by a variety of phenyl hydrazones and comparisons
with other lipoxygenases.
Biochim. Biophys. Acta. 663 (1981) 361-72.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.31
IUBMB Enzyme Nomenclature: 1.13.11.31
ExPASy - ENZYME nomenclature database: 1.13.11.31
BRENDA, the Enzyme Database: 1.13.11.31
CAS: 82391-43-3 |
|---|
