| Entry |
|
|---|
| Name |
benzene 1,2-dioxygenase;
benzene hydroxylase;
benzene dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of
oxygen into the other donor
 |
|---|
| Sysname |
benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating) |
|---|
| Reaction(IUBMB) |
benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+
[RN:R03543] |
|---|
| Reaction(KEGG) |
R03543
 |
|---|
| Substrate |
benzene [CPD:C01407];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
cis-cyclohexa-3,5-diene-1,2-diol [CPD:C04091];
NAD+ [CPD:C00003] |
|---|
| Cofactor |
FAD [CPD:C00016];
Iron [CPD:C00023];
Sulfur [CPD:C00087];
Iron-sulfur [CPD:C00824] |
|---|
| Comment |
A system, containing a reductase which is an iron-sulfur
flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin.
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00626 Naphthalene and anthracene degradation |
|---|
| Orthology |
KO: K03268 benzene 1,2-dioxygenase |
|---|
| Genes |
BUR: Bcep18194_C7072
BBR: BB0730
VEI: Veis_1994
AZO: azo1122(carBa1)
MVA: Mvan_4416
MJL: Mjls_1648
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4298226]
Gibson DT, Koch JR, Kallio RE.
Oxidative degradation of aromatic hydrocarbons by microorganisms. I.
Enzymatic formation of catechol from benzene.
Biochemistry. 7 (1968) 2653-62.
Pseudomonas putida |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.12.3
IUBMB Enzyme Nomenclature: 1.14.12.3
ExPASy - ENZYME nomenclature database: 1.14.12.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.3
BRENDA, the Enzyme Database: 1.14.12.3
CAS: 9075-66-5 |
|---|
