| Entry |
|
|---|
| Name |
phthalate 4,5-dioxygenase;
PDO ;
phthalate dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of
oxygen into the other donor
 |
|---|
| Sysname |
phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating) |
|---|
| Reaction(IUBMB) |
phthalate + NADH + H+ + O2 =
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+
[RN:R03630] |
|---|
| Reaction(KEGG) |
R03630
 |
|---|
| Substrate |
phthalate [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
[CPD:C04783];
NAD+ [CPD:C00003] |
|---|
| Cofactor |
Iron [CPD:C00023];
FMN [CPD:C00061];
Iron-sulfur [CPD:C00824] |
|---|
| Comment |
A system, containing a reductase which is an iron-sulfur
flavoprotein (FMN), an iron-sulfur oxygenase, and no independent
ferredoxin. Requires Fe2+. |
|---|
| Pathway |
PATH: ec00623 2,4-Dichlorobenzoate degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K07519 phthalate 4,5-dioxygenase |
|---|
| Genes |
REU: Reut_B4795 Reut_B5777 Reut_C6324
BUR: Bcep18194_B0531 Bcep18194_B0741 Bcep18194_B2494 Bcep18194_C6765
Bcep18194_C7074 Bcep18194_C7584 Bcep18194_C7699
VEI: Veis_3584
RHA: RHA1_ro00369 RHA1_ro00470 RHA1_ro02824 RHA1_ro03672
RHA1_ro03984 RHA1_ro04256
ART: Arth_1726
SEN: SACE_3556
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3805038]
Batie CJ, LaHaie E, Ballou DP.
Purification and characterization of phthalate oxygenase and
phthalate oxygenase reductase from Pseudomonas cepacia.
J. Biol. Chem. 262 (1987) 1510-8.
Pseudomonas cepacia |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.12.7
IUBMB Enzyme Nomenclature: 1.14.12.7
ExPASy - ENZYME nomenclature database: 1.14.12.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.7
BRENDA, the Enzyme Database: 1.14.12.7
CAS: 63626-44-8 |
|---|
