| Entry |
|
|---|
| Name |
trans-cinnamate 4-monooxygenase;
cinnamic acid 4-hydroxylase;
oxygenase, cinnamate 4-mono-;
CA4H ;
cytochrome P450 cinnamate 4-hydroxylase;
cinnamate 4-hydroxylase;
cinnamate 4-monooxygenase;
cinnamate hydroxylase;
cinnamic 4-hydroxylase;
cinnamic acid 4-monooxygenase;
cinnamic acid p-hydroxylase;
hydroxylase, cinnamate 4-;
t-cinnamic acid hydroxylase;
trans-cinnamate 4-hydroxylase;
trans-cinnamic acid 4-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating) |
|---|
| Reaction(IUBMB) |
trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O
[RN:R02253] |
|---|
| Reaction(KEGG) |
R02253;
(other) R08815
 |
|---|
| Substrate |
trans-cinnamate [CPD:C00423];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
4-hydroxycinnamate [CPD:C00811];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Cofactor |
Heme [CPD:C00032] |
|---|
| Comment |
NADH also acts, more slowly. Involves a heme-thiolate protein
(P-450). |
|---|
| Pathway |
PATH: ec00360 Phenylalanine metabolism
PATH: ec00940 Phenylpropanoid biosynthesis
PATH: ec00941 Flavonoid biosynthesis
PATH: ec00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00487 trans-cinnamate 4-monooxygenase |
|---|
| Genes |
ATH: AT2G30490(C4H)
POP: POPTR_823837(C4H2|CYP73A42)
RCU: RCOM_1164350
VVI: 100253493(GSVIVT00023932001)
OSA: 4338409(Os05g0320700)
SBI: SORBI_03g038160(SORBIDRAFT_03g038160)
ZMA: 100282780
PPP: PHYPADRAFT_149501
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4153152]
Potts JR, Weklych R, Conn EE, Rowell J.
The 4-hydroxylation of cinnamic acid by sorghum microsomes and the
requirement for cytochrome P-450.
J. Biol. Chem. 249 (1974) 5019-26.
Sorghum sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4383827]
Russell DW, Conn EE.
The cinnamic acid 4-hydroxylase of pea seedlings.
Arch. Biochem. Biophys. 122 (1967) 256-8.
Pisum sativum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.11
IUBMB Enzyme Nomenclature: 1.14.13.11
ExPASy - ENZYME nomenclature database: 1.14.13.11
BRENDA, the Enzyme Database: 1.14.13.11
CAS: 9077-75-2 |
|---|
