| Entry |
|
|---|
| Name |
benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating) |
|---|
| Reaction(IUBMB) |
benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O
[RN:R01295] |
|---|
| Reaction(KEGG) |
R01295
 |
|---|
| Substrate |
benzoate [CPD:C00180];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
4-hydroxybenzoate [CPD:C00156];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Cofactor |
Iron [CPD:C00023];
Tetrahydrobiopterin [CPD:C00272];
Tetrahydropteridine [CPD:C05650] |
|---|
| Comment |
Requires Fe2+ and tetrahydropteridine. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K07824 benzoate 4-monooxygenase |
|---|
| Genes |
AFM: AFUA_2G15230
ANG: An09g03500(bphA)
BUR: Bcep18194_C7583
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:236777]
Reddy CC, Vaidyanathan CS.
Purification, properties and induction of a specific
benzoate-4-hydroxylase from Aspergillus niger (UBC 814).
Biochim. Biophys. Acta. 384 (1975) 46-57.
Aspergillus niger [GN:ang] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.12
IUBMB Enzyme Nomenclature: 1.14.13.12
ExPASy - ENZYME nomenclature database: 1.14.13.12
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.12
BRENDA, the Enzyme Database: 1.14.13.12
CAS: 39391-25-8 |
|---|
