| Entry |
|
|---|
| Name |
calcidiol 1-monooxygenase;
25-hydroxycholecalciferol 1-hydroxylase;
25-hydroxycholecalciferol 1-monooxygenase;
1-hydroxylase-25-hydroxyvitamin D3;
25-hydroxy D3-1alpha-hydroxylase;
25-hydroxycholecalciferol 1alpha-hydroxylase;
25-hydroxyvitamin D3 1alpha-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating) |
|---|
| Reaction(IUBMB) |
calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610] |
|---|
| Reaction(KEGG) |
R03610
 |
|---|
| Substrate |
calcidiol [CPD:C01561];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
calcitriol [CPD:C01673];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Pathway |
PATH: ec00100 Steroid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K07438 cytochrome P450, family 27, subfamily B
(25-hydroxyvitamin D3 1alpha-hydroxylase) |
|---|
| Genes |
HSA: 1594(CYP27B1)
PTR: 452027(CYP27B1)
MCC: 715747
MMU: 13115(Cyp27b1)
RNO: 114700(Cyp27b1)
CFA: 481133
BTA: 539630(CYP27B1)
SSC: 397055(CYP27B1)
ECB: 100034100(CYP27B1)
MDO: 100031497
XTR: 448754(cyp27b1)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4404596]
Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF.
25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and
properties.
J. Biol. Chem. 247 (1972) 7528-32.
Gallus gallus [GN:gga] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.13
IUBMB Enzyme Nomenclature: 1.14.13.13
ExPASy - ENZYME nomenclature database: 1.14.13.13
BRENDA, the Enzyme Database: 1.14.13.13
CAS: 9081-36-1 |
|---|
