| Entry |
|
|---|
| Name |
leukotriene-B4 20-monooxygenase;
leukotriene-B4 20-hydroxylase;
leucotriene-B4 omega-hydroxylase;
LTB4 20-hydroxylase;
LTB4 omega-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,N
ADPH:oxygen oxidoreductase (20-hydroxylating) |
|---|
| Reaction(IUBMB) |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate +
NADPH + H+ + O2 =
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-
tetraenoate + NADP+ + H2O [RN:R03866] |
|---|
| Reaction(KEGG) |
R03866
 |
|---|
| Substrate |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
[CPD:C02165];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-
tetraenoate [CPD:C04853];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Cofactor |
Heme [CPD:C00032] |
|---|
| Comment |
A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34,
leukotriene-E4 20-monooxygenase. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00490 cytochrome P450, family 4, subfamily F (leukotriene-B4
20-monooxygenase) |
|---|
| Genes |
HSA: 4051(CYP4F3) 8529(CYP4F2)
PTR: 748117
MCC: 718349 719246
MMU: 106648(Cyp4f15) 170716(Cyp4f13) 64385(Cyp4f14) 70101(Cyp4f16)
72054(Cyp4f18)
RNO: 266689(Cyp4f6) 286904(Cyp4f4) 286905(Cyp4f5) 290623(Cyp4f18)
500801(Cyp4f17) 503122(Cyp4f40) 56266(Cyp4f1)
CFA: 484867
BTA: 507016(CYP4F2) 507615(CYP4F2) 534967(CYP4F3)
ECB: 100062102 100070123 100070707
MDO: 100013359 100013446 100013494
TGU: 100231824
XLA: 100037244
XTR: 548527
DRE: 100037390
SPU: 591685
OLU: OSTLU_29177
UMA: UM00202.1
TET: TTHERM_00198320
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3027095]
Romano MC, Eckardt RD, Bender PE, Leonard TB, Straub KM, Newton JF.
Biochemical characterization of hepatic microsomal leukotriene B4
hydroxylases.
J. Biol. Chem. 262 (1987) 1590-5.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4044832]
Shak S, Goldstein IM.
Leukotriene B4 omega-hydroxylase in human polymorphonuclear
leukocytes. Partial purification and identification as a cytochrome
P-450.
J. Clin. Invest. 76 (1985) 1218-28.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2986111]
Soberman RJ, Harper TW, Murphy RC, Austen KF.
Identification and functional characterization of leukotriene B4
20-hydroxylase of human polymorphonuclear leukocytes.
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2292-5.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.13.30
IUBMB Enzyme Nomenclature: 1.14.13.30
ExPASy - ENZYME nomenclature database: 1.14.13.30
BRENDA, the Enzyme Database: 1.14.13.30
CAS: 90119-11-2 |
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|
