KEGG   ENZYME: 1.14.13.7Help
Entry
EC 1.14.13.7                Enzyme                                 
Name phenol 2-monooxygenase;
phenol hydroxylase;
phenol o-hydroxylase
Class Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen into the other donor
BRITE hierarchy
Sysname phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB) phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O [RN:R00815]
Reaction(KEGG) R00815;
(other) R03560 R03562 R03566 R03568 R03608 R05249
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Substrate phenol [CPD:C00146];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product catechol [CPD:C00090];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Cofactor FAD [CPD:C00016]
Comment A flavoprotein (FAD). Also active with resorcinol and o-cresol.
Pathway PATH: ec00361  gamma-Hexachlorocyclohexane degradation
PATH: ec00622  Toluene and xylene degradation
PATH: ec00626  Naphthalene and anthracene degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K03380  phenol 2-monooxygenase
Genes DHA: DEHA0C15939g
PIC: PICST_57166(PHH2)
MGR: MGG_04639
AFM: AFUA_1G13660 AFUA_3G02620
ANG: An08g06720
XCC: XCC3977(poxF)
XCB: XC_4067
XCV: XCV4151
XAC: XAC4066(poxF)
XOO: XOO0382(poxF)
XOM: XOO_0344
VFI: VF_0061
LPN: lpg0471(poxF)
LPF: lpl0512
LPP: lpp0536
LPC: LPC_2873(poxF)
FTU: FTT_0365(poxF)
FTF: FTF0365(poxF)
FTW: FTW_1699(poxF)
FTL: FTL_1302
FTH: FTH_1274(poxF)
FTN: FTN_0279
REH: H16_B0539(poxA) H16_B0540(poxB) H16_B0541(poxC) H16_B0542(poxD)
     H16_B0543(poxE) H16_B0544(poxF)
BVI: Bcep1808_7598
BUR: Bcep18194_B2966
BPH: Bphy_6383
AJS: Ajs_0211
VEI: Veis_2791
MPT: Mpe_A2280(dmpP)
AZO: azo1222(dmpM) azo1845(lapK) azo1850(lapP) azo2439(poxF)
BBA: Bd2437
BJA: blr4222
BRA: BRADO5224
BBT: BBta_1594 BBta_5688
PDE: Pden_3488
CGL: NCgl0050(cgl0050) NCgl2588(cgl2681)
CGB: cg2966
CGT: cgR_2584
NFA: nfa22280 nfa27810
RHA: RHA1_ro02379 RHA1_ro08076
ART: Arth_3519
AAU: AAur_2032 AAur_pTC20088
RSA: RSal33209_1826 RSal33209_1827
KRH: KRH_22060
RXY: Rxyl_0473
ABA: Acid345_0992
Taxonomy
Structures PDB: 1FOH  1HQI  1PN0  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:14478080]
NAKAGAWA H, TAKEDA Y.
Phenol hydroxylase.
Biochim. Biophys. Acta. 62 (1962) 423-6.
Brevibacterium fuscum
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4146224]
Neujahr HY, Gaal A.
Phenol hydroxylase from yeast. Purification and properties of the
enzyme from Trichosporon cutaneum.
Eur. J. Biochem. 35 (1973) 386-400.
Trichosporon cutaneum
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:810352]
Neujahr HY, Gaal A.
Phenol hydroxylase from yeast. Sulfhydryl groups in phenol
hydroxylase from Trichosporon cutaneum.
Eur. J. Biochem. 58 (1975) 351-7.
Trichosporon cutaneum
Other DBs ExplorEnz - The Enzyme Database: 1.14.13.7
IUBMB Enzyme Nomenclature: 1.14.13.7
ExPASy - ENZYME nomenclature database: 1.14.13.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.7
BRENDA, the Enzyme Database: 1.14.13.7
CAS: 37256-84-1
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