| Entry |
|
|---|
| Name |
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
Miscellaneous
 |
|---|
| Sysname |
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen
oxidoreductase |
|---|
| Reaction(IUBMB) |
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599] |
|---|
| Reaction(KEGG) |
R01599;
(other) R00073 R01590
 |
|---|
| Substrate |
arachidonate [CPD:C00219];
AH2 [CPD:C00030];
O2 [CPD:C00007] |
|---|
| Product |
prostaglandin H2 [CPD:C00427];
A [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Inhibitor |
Aspirin [CPD:C01405];
Naproxen [CPD:C01517];
Sulindac [CPD:C01531];
Ibuprofen [CPD:C01588];
Piroxicam [CPD:C01608];
Diclofenac [CPD:C01690];
Diflunisal [CPD:C01691];
Ketoprofen [CPD:C01716];
Indomethacin [CPD:C01926];
Mefenamic acid [CPD:C02168];
Tolmetin sodium [CPD:C02328];
Fenprofen calcium [CPD:C02539];
Meclofenamate sodium [CPD:C02996] |
|---|
| Comment |
This enzyme acts both as a dioxygenase and as a peroxidase. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00509 prostaglandin-endoperoxide synthase 1
KO: K11987 prostaglandin-endoperoxide synthase 2 |
|---|
| Genes |
HSA: 5742(PTGS1) 5743(PTGS2)
PTR: 464713(PTGS1) 469616(PTGS2)
MCC: 698213(PTGS1) 716671(PTGS2)
MMU: 19224(Ptgs1) 19225(Ptgs2)
RNO: 24693(Ptgs1) 29527(Ptgs2)
CFA: 403544(PTGS1) 442942(PTGS2)
BTA: 282022(PTGS1) 282023(PTGS2)
SSC: 397541(PTGS1) 397590(PGHS-2)
ECB: 100034087(PTGS1) 791253(PGHS2)
MDO: 100016747 100024802
OAA: 100081492 100086096
GGA: 396451(PTGS2) 427752(PTGS1)
TGU: 100221909 100226968
XLA: 100037245(cox1) 446781(ptgs2)
XTR: 595089(ptgs2)
DRE: 246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
BFO: BRAFLDRAFT_129952
CIN: 100183010 100183175
PAN: PODANSg1229
MGR: MGG_10859
ANI: AN5028.2
AFM: AFUA_3G12120
AOR: AO090003000772
ANG: An02g07930
AFV: AFLA_030430
PCS: Pc18g00240
NFI: NFIA_065200
CIM: CIMG_00042
URE: UREG_00168
LBC: LACBIDRAFT_315146
UMA: UM04571.1
NEU: NE1240(Ptgs1)
MET: M446_1624
MNO: Mnod_6498
RSH: Rsph17029_3626
RSK: RSKD131_4262
RDE: RD1_1072
MVA: Mvan_3099
SRO: Sros_8745
NPU: Npun_R5469
 |
|---|
| Structures |
PDB: 1CQE 1CVU 1CX2 1DDX 1DIY 1EBV 1EQG 1EQH 1HT5 1HT8
1PGE 1PGF 1PGG 1PTH 1PXX 1Q4G 1U67 2AYL 2OYE 2OYU
3KK6 3PGH 4COX 5COX 6COX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3125548]
DeWitt DL, Smith WL.
Primary structure of prostaglandin G/H synthase from sheep vesicular
gland determined from the complementary DNA sequence.
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 1412-6.
Ovis aries |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:104998]
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
Prostaglandin hydroperoxidase, an integral part of prostaglandin
endoperoxide synthetase from bovine vesicular gland microsomes.
J. Biol. Chem. 254 (1979) 829-36.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.99.1
IUBMB Enzyme Nomenclature: 1.14.99.1
ExPASy - ENZYME nomenclature database: 1.14.99.1
BRENDA, the Enzyme Database: 1.14.99.1
CAS: 39391-18-9 |
|---|
