KEGG   ENZYME: 1.3.1.34Help
Entry
EC 1.3.1.34                 Enzyme                                 
Name 2,4-dienoyl-CoA reductase (NADPH);
4-enoyl-CoA reductase (NADPH);
4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide
phosphate) reductase;
4-enoyl-CoA reductase;
2,4-dienoyl-CoA reductase (NADPH)
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase
Reaction(IUBMB) trans-2,3-didehydroacyl-CoA + NADP+ =
trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+ [RN:R04319]
Reaction(KEGG) R04319
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Substrate trans-2,3-didehydroacyl-CoA [CPD:C00658];
NADP+ [CPD:C00006]
Product trans,trans-2,3,4,5-tetradehydroacyl-CoA [CPD:C04512];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment Best substrates for reduction contain a 2,4-diene structure with a
chain-length of 8 or 10
Orthology KO: K00219  2,4-dienoyl-CoA reductase (NADPH2)
KO: K13236  2,4-dienoyl-CoA reductase, mitochondrial
KO: K13237  peroxisomal 2,4-dienoyl-CoA reductase
Genes HSA: 1666(DECR1) 26063(DECR2)
PTR: 736777(DECR1)
MCC: 695540(DECR2) 696035(DECR1)
MMU: 26378(Decr2) 67460(Decr1)
RNO: 117543(Decr1) 64461(Decr2)
CFA: 477938(DECR1) 611514
BTA: 509952(DECR1) 768256(DECR2)
SSC: 503544(DECR1)
ECB: 100053423 100065146
MDO: 100020025 100029422
OAA: 100076917 100078257
GGA: 420218(DECR1)
TGU: 100190086(DECR1) 100223602
XLA: 443792
XTR: 447965(decr1)
DRE: 406623(decr2) 436717
BFO: BRAFLDRAFT_118627 BRAFLDRAFT_217214
CIN: 100180648 100185689
SPU: 588523 590477
ISC: IscW_ISCW023460
CEL: F53C11.3
NVE: NEMVE_v1g219165 NEMVE_v1g235656
HMG: 100208057
TAD: TRIADDRAFT_31628 TRIADDRAFT_63390
ATH: AT3G12800(SDRB)
POP: POPTR_570603 POPTR_818972
RCU: RCOM_0893330 RCOM_1574620
VVI: 100248493(GSVIVT00002063001) 100257583(GSVIVT00030139001)
OSA: 4336980(Os04g0614000)
SBI: SORBI_06g028400(SORBIDRAFT_06g028400)
     SORBI_06g028410(SORBIDRAFT_06g028410)
ZMA: 100194355
PPP: PHYPADRAFT_149299 PHYPADRAFT_207588
CRE: CHLREDRAFT_59969
SCE: YNL202W(SPS19)
AGO: AGOS_ABL163W
KLA: KLLA0D18909g
LTH: KLTH0B07656g
DHA: DEHA0C02486g DEHA0G23496g
PIC: PICST_45705 PICST_57591
PPA: PAS_chr3_0975
VPO: Kpol_1054p31
LEL: LELG_01635 LELG_04242
ZRO: ZYRO0C10274g
CAL: CaO19.11168
CTP: CTRG_00064 CTRG_04642
CDU: CD36_02120 CD36_40880
CGR: CAGL0H08063g
YLI: YALI0C03003g
NCR: NCU07958
PAN: PODANSg451
MGR: MGG_05138
FGR: FG00407.1
ANI: AN7770.2
AOR: AO090701000656
ANG: An15g02860
AFV: AFLA_061230
PCS: Pc22g15030
NFI: NFIA_079800
CIM: CIMG_06119
URE: UREG_04269
SSL: SS1G_04630
BFU: BC1G_00143
CNE: CNI03790
CNB: CNBH3620
LBC: LACBIDRAFT_251259(SPS)
MPR: MPER_08115
UMA: UM05147.1
MGL: MGL_1622
TGO: TGME49_026300
TET: TTHERM_00637450
PTM: GSPATT00036343001
TCR: 509941.100
LMA: LmjF33.0830
LIF: LinJ33.0840
LBZ: LbrM33_V2.1020
PTI: PHATRDRAFT_11319(DER1)
TPS: THAPSDRAFT_35810
ECO: b3081(fadH)
ECJ: JW3052(fadH)
ECD: ECDH10B_3256(fadH)
EBW: BWG_2791(fadH)
ECE: Z4434(ygjL)
ECS: ECs3963
ECF: ECH74115_4395(fadH)
ETW: ECSP_4055(fadH)
ECG: E2348C_3374(fadH)
ECC: c3839(ygjL)
ECI: UTI89_C3521(ygjL)
ECP: ECP_3172
ECV: APECO1_3335(ygjL)
ECW: EcE24377A_3548(fadH)
ECX: EcHS_A3263(fadH)
ECM: EcSMS35_3375(fadH)
ECY: ECSE_3362
ECL: EcolC_0619
ECK: EC55989_3495(fadH)
ECQ: ECED1_3749(fadH)
ECR: ECIAI1_3228(fadH)
ECT: ECIAI39_3579(fadH)
ECZ: ECS88_3478(fadH)
EUM: ECUMN_3564(fadH)
ELF: LF82_0617(fadH)
EBL: B21_02900(fadH)
EBD: ECBD_0661
EBR: ECB_02950(fadH)
EOH: ECO103_3826(fadH)
EOI: ECO111_3903(fadH)
EOJ: ECO26_4183(fadH)
EFE: EFER_3054(fadH)
SPT: SPA3087(fadH)
SEK: SSPA2883
SPQ: SPAB_04018
SEI: SPC_3295(fadH)
SEC: SC3166(fadH)
SEH: SeHA_C3514
SEE: SNSL254_A3480
SEW: SeSA_A3410
SEA: SeAg_B3406
SED: SeD_A3576
SEG: SG3115(fadH)
SET: SEN3061(fadH)
SES: SARI_04408
STM: STM3219(fadH)
YPE: YPO0589(fadH)
YPK: y3589
YPM: YP_2909(fadH)
YPA: YPA_3199
YPN: YPN_0458
YPG: YpAngola_A1093(fadH)
YPP: YPDSF_0376
YPS: YPTB3469(fadH)
YPI: YpsIP31758_0501(fadH)
YPY: YPK_0563
YPB: YPTS_3654
YEN: YE3698(fadH)
SFL: SF3121(ygjL)
SFX: S3328(ygjL)
SFV: SFV_3122(ygjL)
SSN: SSON_3124(ygjL)
SBO: SBO_2942(ygjL)
SBC: SbBS512_E3517(fadH)
SDY: SDY_3265(ygjL)
ECA: ECA0655(fadF)
PCT: PC1_0537
PWA: Pecwa_0754
ETA: ETA_28950(fadH)
PLU: plu3990(fadH)
PAY: PAU_03625(fadH)
ENT: Ent638_3539
ESA: ESA_03493
CTU: Ctu_04730(fadH)
KPN: KPN_03510(fadH)
KPE: KPK_0602(fadH)
KPU: KP1_4808(fadH)
CKO: CKO_04487
SPE: Spro_4309
PMR: PMI3702(fadH)
XCC: XCC0933(fadH)
XCB: XC_3302
XCA: xccb100_3420(fadH)
XCV: XCV1039(fadH)
XAC: XAC1010(fadH)
XOO: XOO3698(fadH)
XOM: XOO_3492
XOP: PXO_02526
SML: Smlt0952(fadH)
SMT: Smal_0797
VCH: VC1993
VCO: VC0395_A1578(fadH)
VCM: VCM66_1917(fadH)
VCJ: VCD_002375
VVU: VV1_3132
VVY: VV1153
VPA: VP2151
VHA: VIBHAR_03043
VSP: VS_0938
VEX: VEA_002914
VFI: VF_1642(fadH)
VFM: VFMJ11_1762
VSA: VSAL_I2156(fadH)
PPR: PBPRA2594
PAE: PA3092(fadH1) PA4814(fadH2)
PAU: PA14_24170(fadH1) PA14_63640(fadH2)
PAP: PSPA7_2046(fadH1) PSPA7_5533(fadH2)
PAG: PLES_19681(fadH1) PLES_51991(fadH2)
PPU: PP_2008(fadH)
PPF: Pput_3734
PPG: PputGB1_1540
PPW: PputW619_1568
PST: PSPTO_3803(fadH)
PSB: Psyr_1675
PSP: PSPPH_1672(fadH)
PFL: PFL_3969(noxB-1)
PFO: Pfl01_3687
PFS: PFLU3915
PEN: PSEEN1703(fadH)
PMY: Pmen_2951
PSA: PST_1812(fadH1)
PAR: Psyc_0181(fadH2)
PCR: Pcryo_0194
PRW: PsycPRwf_2110
ACI: ACIAD1155(fadH) ACIAD1654(fadH)
ACB: A1S_1070 A1S_1905
ABM: ABSDF1380(fadH)
ABY: ABAYE1661(fadH) ABAYE2640(fadH)
ABC: ACICU_01106 ACICU_02015
ABN: AB57_1153 AB57_2239
ABB: ABBFA_001549 ABBFA_002475
SON: SO_2419
SDN: Sden_1900
SFR: Sfri_2144
SAZ: Sama_1724
SBL: Sbal_2056
SBM: Shew185_2293
SBN: Sbal195_2410
SBP: Sbal223_2052
SLO: Shew_1942
SPC: Sputcn32_2077
SSE: Ssed_1665 Ssed_2310
SPL: Spea_2146 Spea_2252
SHE: Shewmr4_1910
SHM: Shewmr7_2068
SHN: Shewana3_1965
SHW: Sputw3181_1935
SHL: Shal_2030 Shal_2117
SWD: Swoo_2300 Swoo_2943
SWP: swp_2472
ILO: IL1748
CPS: CPS_0925(fadH1) CPS_2449(fadH2)
PHA: PSHAa0892 PSHAa1410(fadH)
PAT: Patl_1371 Patl_2400
MAQ: Maqu_2074
AMC: MADE_01164 MADE_03303
LPN: lpg2347(fadH)
LPF: lpl2269(fadH)
LPP: lpp2296(fadH)
LPC: LPC_1816(fadH)
NOC: Noc_1799
HCH: HCH_04596
ABO: ABO_1705(fadH)
MMW: Mmwyl1_1337
AHA: AHA_3357
ASA: ASA_0950
KKO: Kkor_1393
CVI: CV_0169(fadH) CV_3946(fadH)
LHK: LHK_00049(fadH)
RPI: Rpic_4232
RPF: Rpic12D_4342
REU: Reut_C6110
BMA: BMAA0192(fadH)
BMV: BMASAVP1_1367
BML: BMA10229_1562(fadH)
BMN: BMA10247_A0222
BPS: BPSS1133(fadH) BPSS1898(fadH)
BPM: BURPS1710b_A0094(fadH) BURPS1710b_A0995(fadH)
BPL: BURPS1106A_A1515 BURPS1106A_A2575
BPD: BURPS668_A1598 BURPS668_A2719
BTE: BTH_II0478 BTH_II1273
BVI: Bcep1808_4153
BUR: Bcep18194_A3253 Bcep18194_A4477 Bcep18194_B0574 Bcep18194_B1624
     Bcep18194_B2335 Bcep18194_B2709 Bcep18194_C7286
BCN: Bcen_0863 Bcen_4599
BCH: Bcen2424_1344 Bcen2424_3764
BCM: Bcenmc03_1323 Bcenmc03_3759
BCJ: BCAL1336(fadH) BCAM0799(fadH)
BAM: Bamb_5493
BAC: BamMC406_3639
BMU: Bmul_4966
BMJ: BMULJ_03548(fadH)
BXE: Bxe_A1452
BPH: Bphy_1515
BPY: Bphyt_2663
BGL: bglu_2g17140
BBR: BB4756(fadH)
BPT: Bpet1213
RFR: Rfer_1891
POL: Bpro_5274
DAC: Daci_4270
CTT: CtCNB1_1321
EBA: ebA5836(fadH)
APP: CAP2UW1_4099
GME: Gmet_2202
GUR: Gura_1595
DOL: Dole_1455
DAL: Dalk_2520 Dalk_2895 Dalk_4717 Dalk_4846
DAT: HRM2_01970 HRM2_03240(fadH)
PLA: Plav_1799
ARA: Arad_7258(stcD)
CAK: Caul_5306
SIL: SPO3586(fadH)
SIT: TM1040_2458
RDE: RD1_0957(fadH)
DSH: Dshi_0125(fadH)
HBA: Hbal_2832
MAG: amb3454
BCL: ABC1993
BBE: BBR47_40570
AAC: Aaci_2399
CKL: CKL_1689
CKR: CKR_1570
DSY: DSY3373
DHD: Dhaf_4536 Dhaf_4602
DRM: Dred_2421
MTU: Rv1175c(fadH)
MTC: MT1212(fadH)
MRA: MRA_1186(fadH)
MTF: TBFG_11200
MTB: TBMG_02806(TBMG_02806.1)
MBO: Mb1208c(fadH)
MBB: BCG_1238c(fadH)
MBT: JTY_1211(fadH)
MSM: MSMEG_5124
MUL: MUL_1023(fadH)
MAB: MAB_1325c
MMI: MMAR_4276(fadH)
CJK: jk0075(fadH)
CUR: cur_0097
NFA: nfa12900
RHA: RHA1_ro01415 RHA1_ro04769 RHA1_ro06074 RHA1_ro06076
RER: RER_38580(fadH)
ROP: ROP_11260(fadH) ROP_61320
GBR: Gbro_2016
SCO: SCO7066(fadH)
SMA: SAV_1292(fadH)
SGR: SGR_825
RSA: RSal33209_2558
KRH: KRH_20600(fadH)
MLU: Mlut_12040
BFA: Bfae_06110
NCA: Noca_4577
ACE: Acel_1198
SEN: SACE_2757 SACE_4167(fadH) SACE_4354
ELE: Elen_1862
LIL: LA2197(fadH)
LIC: LIC11729(fadH)
LBJ: LBJ_1360(fadH)
LBL: LBL_1585(fadH)
LBI: LEPBI_I2046(fadH2) LEPBI_I2481(fadH)
LBF: LBF_1993(fadH-1) LBF_2407(fadH)
AVA: Ava_C0148
NPH: NP5226A
Taxonomy
Structures PDB: 1PS9  1W6U  1W73  1W8D  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:6749495]
Dommes V, Luster W, Cvetanovic M, Kunau WH.
Purification by affinity chromatography of 2,4-dienoyl-CoA
reductases from bovine liver and Escherichia coli.
Eur. J. Biochem. 125 (1982) 335-41.
Bos taurus [GN:bta], Escherichia coli [GN:eco]
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:729581]
Kunau WH, Dommes P.
Degradation of unsaturated fatty acids. Identification of
intermediates in the degradation of cis-4-decenoly-CoA by extracts
of beef-liver mitochondria.
Eur. J. Biochem. 91 (1978) 533-44.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 1.3.1.34
IUBMB Enzyme Nomenclature: 1.3.1.34
ExPASy - ENZYME nomenclature database: 1.3.1.34
BRENDA, the Enzyme Database: 1.3.1.34
CAS: 82869-38-3
DBGET integrated database retrieval system