KEGG   ENZYME: 1.3.99.16Help
Entry
EC 1.3.99.16                Enzyme                                 
Name isoquinoline 1-oxidoreductase
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname isoquinoline:acceptor 1-oxidoreductase (hydroxylating)
Reaction(IUBMB) isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced
acceptor [RN:R05151]
Reaction(KEGG) R05151
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Substrate isoquinoline [CPD:C06323];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product isoquinolin-1(2H)-one [CPD:C06324];
reduced acceptor [CPD:C00030]
Comment The enzyme from Pseudomonas diminuta is specific towards
N-containing N-heterocyclic substrates, including isoquinoline,
isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors
include 1,2-benzoquinone, cytochrome c, ferricyanide,
iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue
and phenazine methosulfate.
Orthology KO: K00256  isoquinoline 1-oxidoreductase
KO: K07302  isoquinoline 1-oxidoreductase, alpha subunit
KO: K07303  isoquinoline 1-oxidoreductase, beta subunit
Genes SPE: Spro_2319 Spro_2320
PAE: PA1880 PA1881 PA2378 PA2379
PAU: PA14_33890(aldG) PA14_33900 PA14_40180 PA14_40200
PAP: PSPA7_2882 PSPA7_2883 PSPA7_3405 PSPA7_3406
PAG: PLES_29231 PLES_29241 PLES_34421 PLES_34431
PPU: PP_2477 PP_2478 PP_3621 PP_3622
PPF: Pput_2111 Pput_2112
PPG: PputGB1_2295 PputGB1_2296
PPW: PputW619_2833 PputW619_2834
PFL: PFL_1783 PFL_1784
PFO: Pfl01_2173 Pfl01_2174 Pfl01_2472 Pfl01_2473 Pfl01_3425
     Pfl01_4169 Pfl01_4170
PFS: PFLU2271 PFLU2272
PEN: PSEEN2171 PSEEN2172
PMY: Pmen_2198 Pmen_2199 Pmen_4482 Pmen_4483
PSA: PST_0454 PST_0455
AVN: Avin_25840 Avin_25850 Avin_26060 Avin_26070 Avin_35540
     Avin_35550
SON: SO_3048 SO_3049
SDN: Sden_2223 Sden_2224
SFR: Sfri_0200
SAZ: Sama_3438 Sama_3439
SBL: Sbal_2729 Sbal_2730
SBM: Shew185_2746 Shew185_2747
SBN: Sbal195_2822 Sbal195_2823
SBP: Sbal223_1629 Sbal223_1630
SLO: Shew_2265 Shew_2266
SPC: Sputcn32_2424 Sputcn32_2425
SHE: Shewmr4_1440
SHN: Shewana3_1496 Shewana3_1497
SHW: Sputw3181_1583 Sputw3181_1584
SWD: Swoo_2949 Swoo_2950
CPS: CPS_0277(iorB) CPS_0278(iorA)
PAT: Patl_2601 Patl_2602
SDE: Sde_2853
MAQ: Maqu_0905 Maqu_0906
AMC: MADE_02378 MADE_02379 MADE_02524
PIN: Ping_1831
TTU: TERTU_4680 TERTU_4681
TCX: Tcr_0231 Tcr_0232
HCH: HCH_01589(coxS) HCH_01590(coxL) HCH_05037
CVI: CV_1673 CV_1674
RSO: RS05441(RSp0325) RS05442(RSp0324) RSc0626 RSc0627
     RSc1889(iorB2) RSc1890(iorA2)
RPI: Rpic_2090 Rpic_2091 Rpic_4804 Rpic_4805
RPF: Rpic12D_1767 Rpic12D_1768 Rpic12D_3727 Rpic12D_3728
REU: Reut_A1743 Reut_A1744 Reut_A2509 Reut_A2661 Reut_A2662
REH: H16_A0700(coxS2) H16_A0701(coxL2) H16_A1652(iorB1)
     H16_A1653(iorA1) H16_B1377(coxL6) H16_B1523(iorB2)
     H16_B1524(iorA2)
RME: Rmet_0594 Rmet_0595
CTI: RALTA_A0660 RALTA_A0661 RALTA_B0302(iorB) RALTA_B0303(iorA)
     RALTA_B0460(iorA2) RALTA_B0461(iorB2) RALTA_B1306(iorB1)
     RALTA_B1307(iorA1)
BMA: BMAA1154(iorA) BMAA1154.1(iorB)
BML: BMA10229_0085(iorB) BMA10229_0086(iorA)
BMN: BMA10247_A1530(iorA) BMA10247_A1531(iorB)
BPS: BPSS0679 BPSS0680
BPM: BURPS1710b_A2249(iorB) BURPS1710b_A2250(iorA)
BPL: BURPS1106A_A0921 BURPS1106A_A0922
BPD: BURPS668_A1006 BURPS668_A1007
BTE: BTH_II1746 BTH_II1747
BVI: Bcep1808_4960 Bcep1808_4961
BUR: Bcep18194_A4470 Bcep18194_A4471 Bcep18194_A4956 Bcep18194_A4957
     Bcep18194_B0641 Bcep18194_B0642 Bcep18194_B0806 Bcep18194_B0807
     Bcep18194_B0862 Bcep18194_B0863 Bcep18194_B1603
BCN: Bcen_3174 Bcen_3960
BCH: Bcen2424_4407 Bcen2424_5194
BCM: Bcenmc03_1317 Bcenmc03_1318 Bcenmc03_5082 Bcenmc03_5083
     Bcenmc03_5447 Bcenmc03_5448 Bcenmc03_5950 Bcenmc03_5951
     Bcenmc03_6356 Bcenmc03_6357
BCJ: BCAL1074(iorA) BCAL1330 BCAL1331 BCAM1539 BCAM1540 BCAM2037
     BCAM2038 BCAM2097 BCAM2098 BCAM2262 BCAS0319 BCAS0320(iorA)
BAC: BamMC406_1074 BamMC406_1256 BamMC406_1257 BamMC406_4295
     BamMC406_4296 BamMC406_4733 BamMC406_4734
BMU: Bmul_1691 Bmul_1692 Bmul_1961 Bmul_1962 Bmul_2111 Bmul_3615
     Bmul_3757 Bmul_3758 Bmul_4113 Bmul_4114 Bmul_4217 Bmul_4218
BMJ: BMULJ_01133(coxS) BMULJ_01280(iorA) BMULJ_01281(coxL)
     BMULJ_01550(iorA) BMULJ_01551(iorB) BMULJ_04288(iorA)
     BMULJ_04289(iorB) BMULJ_04390(iorA) BMULJ_04391(coxL)
     BMULJ_04758(iorA) BMULJ_04759(iorB) BMULJ_04902(iorB)
BXE: Bxe_B1690 Bxe_B1691 Bxe_B2506 Bxe_B2616 Bxe_B2617
BPH: Bphy_3251 Bphy_3252 Bphy_4016 Bphy_4017 Bphy_6800 Bphy_7214
     Bphy_7215
BPY: Bphyt_4959 Bphyt_4960 Bphyt_6628 Bphyt_6629 Bphyt_7145
     Bphyt_7146
BGL: bglu_2g03190 bglu_2g03200
BPE: BP2126 BP2127
BPA: BPP0703 BPP0704 BPP1351
BBR: BB0710 BB0711 BB2417 BB2418
BPT: Bpet2927(iorA1) Bpet2928(iorB1) Bpet4125(iorB2) Bpet4126(iorA2)
POL: Bpro_3556 Bpro_3557 Bpro_4058 Bpro_4227 Bpro_4228
AAV: Aave_3932
DAC: Daci_4892 Daci_4893 Daci_5621 Daci_5622
VAP: Vapar_3840 Vapar_3841 Vapar_5484 Vapar_5485 Vapar_5895
     Vapar_5896 Vapar_6320 Vapar_6321
CTT: CtCNB1_2033 CtCNB1_2034
MPT: Mpe_A2929 Mpe_A2930 Mpe_A3626 Mpe_A3627
HAR: HEAR1179(iorA) HEAR1180(iorB)
MMS: mma_0765 mma_0766(coxS)
LCH: Lcho_0067 Lcho_0068 Lcho_1987 Lcho_1988 Lcho_4305 Lcho_4306
AZO: azo0021(iorA) azo0022(iorB)
DAR: Daro_1891 Daro_1892
MFA: Mfla_2619 Mfla_2620
MMB: Mmol_1774 Mmol_1775
MEI: Msip34_1371 Msip34_1372
APP: CAP2UW1_3201 CAP2UW1_3202
GSU: GSU0200(iorA) GSU0201(iorB)
GME: Gmet_0837 Gmet_0838 Gmet_3490
ADE: Adeh_3102 Adeh_3103
ACP: A2cp1_3297 A2cp1_3298
ANK: AnaeK_3212 AnaeK_3213
MXA: MXAN_1751(iorA) MXAN_1752(iorB) MXAN_4829(iorB) MXAN_4830(iorA)
SCL: sce3336 sce3337 sce6333 sce6334
HOH: Hoch_0273 Hoch_0274 Hoch_3950 Hoch_3951 Hoch_4546 Hoch_4547
     Hoch_5635 Hoch_5636
MLO: mll3836 mll3837
PLA: Plav_0123 Plav_0124
SME: SM_b20342 SM_b20343 SMa1488 SMa1491
SMD: Smed_3776 Smed_3777 Smed_6324
RLE: RL2499(iorA) RL2500(iorB)
RHI: NGR_b22100 NGR_b22110
BJA: bll1530 bll1531 bll2736 bll2737 blr6218 blr6219
BRA: BRADO0449(iorA) BRADO0450 BRADO1711 BRADO1712 BRADO2114
     BRADO2115 BRADO2413 BRADO2414 BRADO5488(iorA) BRADO5489(iorB)
     BRADO7136 BRADO7137
BBT: BBta_2023 BBta_2287(iorA) BBta_2288 BBta_2423 BBta_2424
     BBta_2766 BBta_2767 BBta_3260(iorA) BBta_3261 BBta_5972(iorA)
     BBta_5973(iorB)
RPC: RPC_3465
XAU: Xaut_2916 Xaut_2917
AZC: AZC_0419 AZC_0420 AZC_1393 AZC_1394 AZC_3274 AZC_3275
MEX: Mext_0210 Mext_0211 Mext_0913 Mext_0914 Mext_4528 Mext_4529
MEA: Mex_1p0102(iorA) Mex_1p0103(iorB) Mex_1p0684 Mex_1p0685
     Mex_1p4977 Mex_1p4978 Mex_2p0884
MDI: METDI0091(iorA) METDI0092(iorB) METDI1056 METDI1057 METDI5579
     METDI5580
MRD: Mrad2831_1272 Mrad2831_1273 Mrad2831_1750 Mrad2831_1751
     Mrad2831_3933 Mrad2831_3934 Mrad2831_4442 Mrad2831_4443
MET: M446_1417 M446_1418 M446_2575 M446_2576 M446_3046 M446_3047
     M446_6069 M446_6070
MPO: Mpop_0713 Mpop_0714 Mpop_0849 Mpop_0850 Mpop_5041 Mpop_5042
MCH: Mchl_0154 Mchl_0155 Mchl_0874 Mchl_0875 Mchl_4988 Mchl_4989
MNO: Mnod_1032 Mnod_1033 Mnod_4568 Mnod_4569 Mnod_4818 Mnod_4819
     Mnod_6606 Mnod_6607
BID: Bind_2919 Bind_2920 Bind_3368
MSL: Msil_2460 Msil_2461
CCR: CC_0021 CC_2270
CCS: CCNA_00021 CCNA_00022 CCNA_02352 CCNA_02353
CAK: Caul_0050 Caul_1416 Caul_1417 Caul_3606
PZU: PHZ_c3051(iorB) PHZ_c3052(iorA)
SIL: SPO2826(iorA) SPO2827
SIT: TM1040_3146 TM1040_3147 TM1040_3229 TM1040_3230
RSP: RSP_3163 RSP_3164
RSH: Rsph17029_3901 Rsph17029_3902
RSQ: Rsph17025_3146 Rsph17025_3147
RSK: RSKD131_3338 RSKD131_3339
RDE: RD1_0246(iorA) RD1_0247(iorB) RD1_A0087 RD1_A0088(iorA)
DSH: Dshi_0864 Dshi_0865
HNE: HNE_2202 HNE_2482 HNE_2483
HBA: Hbal_1429 Hbal_1430 Hbal_1773 Hbal_1774
NAR: Saro_1702 Saro_1703
SWI: Swit_3868 Swit_3976 Swit_3977 Swit_4597
ELI: ELI_11225 ELI_11230
GOX: GOX0586
GDI: GDI_1785(iorA) GDI_1786(iorB) GDI_3280
GDJ: Gdia_0014 Gdia_0015 Gdia_3087
APT: APA01_04660 APA01_04670 APA01_10270
MAG: amb4196
SMA: SAV_515 SAV_516
SRO: Sros_5153 Sros_5154
SEN: SACE_2974(iorA) SACE_2975(iorB)
AMI: Amir_4124 Amir_4125 Amir_4376 Amir_4377
ABA: Acid345_1932 Acid345_3112
RMR: Rmar_0584 Rmar_0585
DFE: Dfer_0018 Dfer_0019 Dfer_0731 Dfer_3445 Dfer_3446
CPI: Cpin_4139 Cpin_4140
RBI: RB2501_01016 RB2501_01021 RB2501_01026 RB2501_01031
     RB2501_02795 RB2501_13024
OTE: Oter_2802 Oter_2803
GAU: GAU_2679 GAU_2918 GAU_2919 GAU_3648 GAU_3649 GAU_3824(iorB)
     GAU_3825(iorA)
CAU: Caur_1726 Caur_1727
CAG: Cagg_2899
CHL: Chy400_1870 Chy400_1871
AAE: aq_227(aldH2)
SAF: SULAZ_1264 SULAZ_1265
Taxonomy
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:8157655]
Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F.
Purification and characterization of isoquinoline 1-oxidoreductase
from Pseudomonas diminuta 7, a novel molybdenum-containing
hydroxylase.
J. Biol. Chem. 269 (1994) 11254-60.
Pseudomonas sp.
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:7782304]
Lehmann M, Tshisuaka B, Fetzner S, Lingens F.
Molecular cloning of the isoquinoline 1-oxidoreductase genes from
Pseudomonas diminuta 7, structural analysis of iorA and iorB, and
sequence comparisons with other molybdenum-containing hydroxylases.
J. Biol. Chem. 270 (1995) 14420-9.
Pseudomonas sp.
Other DBs ExplorEnz - The Enzyme Database: 1.3.99.16
IUBMB Enzyme Nomenclature: 1.3.99.16
ExPASy - ENZYME nomenclature database: 1.3.99.16
BRENDA, the Enzyme Database: 1.3.99.16
CAS: 155948-73-5
DBGET integrated database retrieval system