KEGG   ENZYME: 1.4.1.1Help
Entry
EC 1.4.1.1                  Enzyme                                 
Name alanine dehydrogenase;
AlaDH;
L-alanine dehydrogenase;
NAD+-linked alanine dehydrogenase;
alpha-alanine dehydrogenase;
NAD+-dependent alanine dehydrogenase;
alanine oxidoreductase;
NADH-dependent alanine dehydrogenase
Class Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname L-alanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB) L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+ [RN:R00396]
Reaction(KEGG) R00396;
(other) R00145 R00146 R00365
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Substrate L-alanine [CPD:C00041];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product pyruvate [CPD:C00022];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Pathway ec00250  Alanine, aspartate and glutamate metabolism
ec00430  Taurine and hypotaurine metabolism
ec00720  Reductive carboxylate cycle (CO2 fixation)
Orthology K00259  alanine dehydrogenase
Genes HAP: HAPS_1913(ald)
XAL: XALc_1972
VCH: VC1905
VCO: VC0395_A1495(ald)
VCM: VCM66_1829(ald)
VCJ: VCD_002457
VVU: VV1_2952
VVY: VV1320
VPA: VP1103
VHA: VIBHAR_01795
VSP: VS_2048
VEX: VEA_003881
VFI: VF_0903(ald)
VFM: VFMJ11_0941(ald)
VSA: VSAL_I1839(aladh)
PPR: PBPRA1160 PBPRA2201
PMY: Pmen_0473
CJA: CJA_2073(ald)
AVN: Avin_05750
SDN: Sden_1741
SFR: Sfri_1793
SAZ: Sama_1770
SBL: Sbal_2154
SBM: Shew185_2217
SBN: Sbal195_2325
SBP: Sbal223_2189
SLO: Shew_2026
SPC: Sputcn32_2013
SSE: Ssed_2125
SPL: Spea_2235
SHE: Shewmr4_1961
SHM: Shewmr7_2015
SHN: Shewana3_2048
SHW: Sputw3181_1999
SHL: Shal_2219
SWD: Swoo_2485
SWP: swp_2594
SVO: SVI_2298(ald)
ILO: IL0669(pntA)
CPS: CPS_2761(ald)
PHA: PSHAa1718
PAT: Patl_2462
AMC: MADE_02114
PIN: Ping_3605
TTU: TERTU_1560(ald)
CBU: CBU_1116(ald)
CBS: COXBURSA331_A1261(ald)
CBD: CBUD_1216(ald)
CBG: CbuG_0893(ald)
CBC: CbuK_0982(ald)
LPN: lpg0924(ald)
LPF: lpl0955(ald)
LPP: lpp0986(ald)
LPC: LPC_2367(ald)
LPA: lpa_01395(ald)
LLO: LLO_0869(ald)
MCA: MCA0563(ald)
NOC: Noc_0346
NHL: Nhal_3421
NWA: Nwat_2757
TGR: Tgr7_2005
HCH: HCH_00974(ald)
CSA: Csal_2966
AHA: AHA_0248(ald)
ASA: ASA_4150(ald)
TAU: Tola_2315
KKO: Kkor_1117
CVI: CV_2022(ald)
LHK: LHK_02210(ald)
REU: Reut_A1168 Reut_B5878
REH: H16_A2009(ald)
BPS: BPSS1090(ald)
BPM: BURPS1710b_A0039(ald)
BPL: BURPS1106A_A1449(ald)
BPD: BURPS668_A1536(ald)
BTE: BTH_II0922(ald)
BVI: Bcep1808_4791
BUR: Bcep18194_B1797
BCN: Bcen_4146
BCH: Bcen2424_4220
BCM: Bcenmc03_3297
BCJ: BCAM1353(ald)
BAM: Bamb_3643
BAC: BamMC406_4118
BMU: Bmul_4385
BMJ: BMULJ_04122(ald)
BPH: Bphy_5016
BPY: Bphyt_5117 Bphyt_7155
PNU: Pnuc_0666
RFR: Rfer_4054
POL: Bpro_3222
NEU: NE0022
NET: Neut_0212
NMU: Nmul_A1155
EBA: ebA3623(ald)
DAR: Daro_2145
TBD: Tbd_0644
MMB: Mmol_1421
APP: CAP2UW1_2015
SLT: Slit_2149
GCA: Galf_0012
HPY: HP1398
HPJ: jhp1428(ald)
HPA: HPAG1_1472
HPS: HPSH_07920
HPG: HPG27_1461
HPP: HPP12_1514(ald)
HPB: HELPY_1513(ald)
HPL: HPB8_1700(ald)
HAC: Hac_1765(ald)
HMS: HMU01260(ald) HMU04860
ANT: Arnit_0574
GSU: GSU2292(ald)
GME: Gmet_1099
GUR: Gura_1607
GLO: Glov_3004
GBM: Gbem_1176
GEO: Geob_1198
GEM: GM21_3119
PCA: Pcar_0416(ald)
DVU: DVU0571(ald)
DVL: Dvul_2381
DVM: DvMF_2154
DDE: Dde_1553
DMA: DMR_45640(ald)
DSA: Desal_3303 Desal_3402
DBA: Dbac_3071
DRT: Dret_1485
BBA: Bd2478(alaDH)
DPS: DP0540 DP0544
DOL: Dole_1068 Dole_1134
DAL: Dalk_1068
DAT: HRM2_46090(ald2)
ADE: Adeh_2109
ACP: A2cp1_1847
ANK: AnaeK_1767
MXA: MXAN_4146(ald)
SCL: sce8152(ald)
HOH: Hoch_5339
SAT: SYN_00979
SFU: Sfum_3106
DBR: Deba_0133
PUB: SAR11_0809(ald)
MLO: mll0362 mll9089
MES: Meso_1428
PLA: Plav_1557
SME: SMc01169(ald)
SMD: Smed_1368
ARA: Arad_2074(ald)
AVI: Avi_3404
RET: RHE_CH01770(aldA)
REC: RHECIAT_CH0001858(aldA)
RLE: RL1966(ald)
RLT: Rleg2_1433
RLG: Rleg_1610
RHI: NGR_c14930
OAN: Oant_4159
BJA: blr1738(aldA) blr3179
BID: Bind_1570
CCR: CC_3574
CCS: CCNA_03689
CAK: Caul_0064
CSE: Cseg_4059
PZU: PHZ_c0271
BSB: Bresu_0170
SIL: SPO0222(ald)
SIT: TM1040_3628
RSP: RSP_0723(ald)
RSH: Rsph17029_2378
RSQ: Rsph17025_2442
RSK: RSKD131_2081
RCP: RCAP_rcc00484(ald)
JAN: Jann_0458
RDE: RD1_1033(ald)
PDE: Pden_1729
DSH: Dshi_0244(adh)
MMR: Mmar10_1058
HNE: HNE_0971(ald)
HBA: Hbal_0634 Hbal_2523
NAR: Saro_1682
SAL: Sala_0558
SWI: Swit_2063
SJP: SJA_C1-31490(ald)
ELI: ELI_11875
ACR: Acry_0543
RRU: Rru_A3686
RCE: RC1_0762(ald)
MAG: amb4487
AZL: AZL_d04070(ald)
APB: SAR116_2542
MGM: Mmc1_0055
BSU: BSU31930(ald)
BHA: BH2329(ald) BH3180
BAN: BA_0592(ald-1) BA_4873(ald-2)
BAR: GBAA_0592(ald-1) GBAA_4873(ald-2)
BAT: BAS0561 BAS4521
BAH: BAMEG_3993(ald1) BAMEG_4905(ald2)
BAI: BAA_0676(ald1) BAA_4884(ald2)
BAL: BACI_c06020(ald) BACI_c46200
BCE: BC0592 BC4623
BCA: BCE_0659(ald) BCE_4758(ald)
BCZ: BCZK0505(ald) BCZK4368(ald)
BCR: BCAH187_A0720(ald1) BCAH187_A4752(ald2)
BCB: BCB4264_A0630(ald1) BCB4264_A4731(ald2)
BCU: BCAH820_0649(ald1) BCAH820_4741(ald2)
BCG: BCG9842_B0504(ald2) BCG9842_B4707(ald1)
BCQ: BCQ_0658(ald) BCQ_4431(ald)
BCX: BCA_0625(ald1) BCA_4739(ald2)
BCY: Bcer98_0509 Bcer98_3299
BTK: BT9727_0503(ald) BT9727_4357(ald)
BTL: BALH_0532(ald) BALH_4204(ald)
BTB: BMB171_C0517(ald1) BMB171_C4263(ald2)
BWE: BcerKBAB4_0506 BcerKBAB4_4453 BcerKBAB4_5593
BLI: BL00190 BL03009(ald)
BLD: BLi03382(ald) BLi04275
BCL: ABC0767(ald)
BAY: RBAM_028980(ald)
BPU: BPUM_2862(ald)
BPF: BpOF4_09775 BpOF4_19385
BMQ: BMQ_4787(ald) BMQ_5213(ald)
BMD: BMD_4773(ald) BMD_5199(ald)
BSE: Bsel_1481
OIH: OB2188 OB3225
GKA: GK2752 GK3448
GTN: GTNG_2677 GTNG_3381
GWC: GWCH70_2698 GWCH70_3380
GYM: GYMC10_1371
GYC: GYMC61_0765 GYMC61_3512
GCT: GC56T3_0741 GC56T3_3428
AFL: Aflv_2789(ald)
SAU: SA1272 SA1531(ald)
SAV: SAV1439 SAV1709(ald)
SAW: SAHV_1427 SAHV_1695(ald)
SAH: SaurJH1_1528 SaurJH1_1800
SAJ: SaurJH9_1499 SaurJH9_1765
SAM: MW1328 MW1652(ald)
SAS: SAS1382 SAS1636
SAR: SAR1451(ald2) SAR1787(ald1)
SAC: SACOL1478(ald1) SACOL1758(ald2)
SAX: USA300HOU_1376(ald1) USA300HOU_1696(ald)
SAA: SAUSA300_1331(ald) SAUSA300_1655(ald)
SAO: SAOUHSC_01452 SAOUHSC_01818
SAE: NWMN_1349(ald) NWMN_1603(ald)
SAD: SAAV_1423(ald1) SAAV_1719(ald2)
SAB: SAB1304c(ald) SAB1568c(ald)
SEP: SE1384
SER: SERP1272(ald)
SHA: SH1216(ald)
SSP: SSP1057
SCA: Sca_1314(ald)
SLG: SLGD_01221 SLGD_02329
LMO: lmo1579
LMF: LMOf2365_1601(ald)
LMH: LMHCC_0989(ald)
LMC: Lm4b_01590
LMN: LM5578_1725
LMY: LM5923_1677
LIN: lin1614
LWE: lwe1592(ald)
LSG: lse_1494(ald)
LSP: Bsph_4140
ESI: Exig_2869
EAT: EAT1b_2028
MCL: MCCL_1376(ald)
BBE: BBR47_49390(ald)
PJD: Pjdr2_2331 Pjdr2_4684
AAC: Aaci_0984
BTS: Btus_1322 Btus_3088
LLK: LLKF_0282(ceo)
SPR: spr0852 spr0853 spr0854
SPW: SPCG_0927 SPCG_0928
SNC: HMPREF0837_11537 HMPREF0837_11538 HMPREF0837_11539
STC: str0556
STL: stu0556
SSA: SSA_1615
SGO: SGO_0708(ald)
LSL: LSL_1768(ald)
LBR: LVIS_1053
LCA: LSEI_2182
LCB: LCABL_23560(ald1)
LCZ: LCAZH_2142
PPE: PEPE_0166
CKL: CKL_0660(ald)
CKR: CKR_0586
STH: STH1822
DSY: DSY0985
DHD: Dhaf_2068
DRM: Dred_2866
PTH: PTH_0658(ald)
APR: Apre_1404
TTE: TTE0161(ald)
TEX: Teth514_0104
TPD: Teth39_2099
TIT: Thit_0137
TMT: Tmath_0194
CHY: CHY_0666(ald)
TOC: Toce_1453
NTH: Nther_1670
HOR: Hore_21130
MMY: MSC_0064(ald)
MMO: MMOB1000(ald)
ACL: ACL_1095(ald)
MTU: Rv2780(ald)
MTC: MT2850(ald)
MRA: MRA_2804(ald)
MTF: TBFG_12793
MTB: TBMG_01194(TBMG_01194.1)
MBO: Mb2802(aldA) Mb2803(aldB)
MBB: BCG_2797(ald_a) BCG_2798(aldB)
MBT: JTY_2791(ald_a) JTY_2792(aldB)
MLE: ML1532(ald)
MLB: MLBr_01532(ald)
MPA: MAP2888(ald)
MAV: MAV_3674(ald)
MSM: MSMEG_2659(ald)
MUL: MUL_2154(ald)
MVA: Mvan_2355
MGI: Mflv_4017
MAB: MAB_3100
MMC: Mmcs_2104
MKM: Mkms_2150
MJL: Mjls_2087
MMI: MMAR_1928(ald)
CAR: cauri_2048(ald)
CPU: cpfrc_01344(ald)
NFA: nfa16250
RHA: RHA1_ro03547(ald1) RHA1_ro04466(ald2)
RER: RER_08750(ald)
ROP: ROP_33410(ald) ROP_43840(ald)
GBR: Gbro_2170
TPR: Tpau_1743
SCO: SCO1773(SCI51.13c)
SMA: SAV_6507(ald)
SGR: SGR_5724
SCB: SCAB_71831
LXX: Lxx12100(ald)
CMI: CMM_2898(aldA)
CMS: CMS_2925(ald)
ART: Arth_1744 Arth_4012
AAU: AAur_3870(ald) AAur_pTC10072(ald) AAur_pTC20204(ald)
ACH: Achl_3803
RSA: RSal33209_2832
KRH: KRH_01980(ald)
MLU: Mlut_19910
BFA: Bfae_14670
JDE: Jden_1608
KSE: Ksed_03060
XCE: Xcel_1771
SKE: Sked_21050
CFL: Cfla_2017
PAC: PPA2268 PPA2274
PAK: HMPREF0675_5343(ald_1)
PFR: PFREUD_00370(ald)
NCA: Noca_2488
KFL: Kfla_5119
TFU: Tfu_0961
NDA: Ndas_0622
TCU: Tcur_3131
SRO: Sros_1520 Sros_2565
ACE: Acel_1288
NML: Namu_0568 Namu_4356
GOB: Gobs_1930 Gobs_2995
KRA: Krad_4085
SEN: SACE_6380(ald)
TBI: Tbis_0822
AMD: AMED_7939(ald)
AMI: Amir_6248
STP: Strop_1923
SAQ: Sare_1914
MAU: Micau_2419
CAI: Caci_2450
SNA: Snas_4430
RXY: Rxyl_2908
CWO: Cwoe_1334 Cwoe_3482
AFO: Afer_0698
PCU: pc1486(ald)
WCH: wcw_1628(ald)
BRM: Bmur_2630
BPO: BP951000_0036(ald)
ACA: ACP_1690(ald)
SUS: Acid_5309 Acid_5426
BTH: BT_1554
BFR: BF1475
BFS: BF1406(ald)
BVU: BVU_3807
PDI: BDI_0483 BDI_2808
PRU: PRU_2067(ald)
SRU: SRU_0902(ald)
SRM: SRM_01094(ald)
RMR: Rmar_0465
CHU: CHU_1995(alaDH) CHU_2439(pntA)
DFE: Dfer_0203 Dfer_4962
SLI: Slin_2902 Slin_2994
CPI: Cpin_1259
PHE: Phep_4284
GFO: GFO_1781(ald)
FJO: Fjoh_0022 Fjoh_2909
FPS: FP1068(ald)
FBA: FIC_01468
COC: Coch_1939
RBI: RB2501_08320 RB2501_15249
ZPR: ZPR_2358
CAT: CA2559_10273
OTE: Oter_2448
MIN: Minf_1758(ald)
GAU: GAU_1762
RBA: RB1363(ald)
PSL: Psta_1974
PLM: Plim_3804
TAI: Taci_1131
SYN: sll1682
SYW: SYNW0501(ald)
SYC: syc2332_c(ald)
SYF: Synpcc7942_1760
SYD: Syncc9605_2181
SYG: sync_2295(ald)
SYR: SynRCC307_1871(ald)
SYX: SynWH7803_2010(ald)
SYP: SYNPCC7002_A2774(ald)
CYA: CYA_1112(ald)
CYB: CYB_1358(ald)
TEL: tlr2107
MAR: MAE_61020
CYT: cce_0036(ald)
CYP: PCC8801_1609
CYC: PCC7424_4283
CYN: Cyan7425_1177
CYH: Cyan8802_1635
CYU: UCYN_08500
GVI: glr3969
ANA: alr2355
NPU: Npun_R3990
AVA: Ava_0176
NAZ: Aazo_3584
PMA: Pro1600(ald)
PMT: PMT1462(ald)
PMF: P9303_04881(ald)
TER: Tery_3174
AMR: AM1_4331(ald)
CTE: CT0650 CT0706(ald)
CPC: Cpar_0651 Cpar_0677
CCH: Cag_1878
CPH: Cpha266_0875 Cpha266_0906
CPB: Cphamn1_1700
CLI: Clim_0767 Clim_1654
PVI: Cvib_1152
PLT: Plut_0627 Plut_0663
PPH: Ppha_2150
PAA: Paes_0761
CTS: Ctha_1261 Ctha_1693
DEB: DehaBAV1_0238
RRS: RoseRS_0909
RCA: Rcas_3772
TRO: trd_1056(ald)
DRA: DR_1895
DGE: Dgeo_0771
DDR: Deide_18020(ald2)
TRA: Trad_2499
TTH: TTC1082 TTC1770
TTJ: TTHA0216 TTHA1447
MRB: Mrub_2747
MSV: Mesil_3009
DTH: DICTH_0907(ald)
DTU: Dtur_1049
NDE: NIDE1244(ald)
DDF: DEFDS_1172(ald)
DAP: Dacet_1148
MMP: MMP1513(ald)
MMQ: MmarC5_0062
MMX: MmarC6_1159
MMZ: MmarC7_0759
MVN: Mevan_0825
MBU: Mbur_1274
MTP: Mthe_0713
MTH: MTH1495
Taxonomy
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13730044]
O'CONNOR RJ, HALVORSON H.
The substrate specificity of L-alanine dehydrogenase.
Biochim. Biophys. Acta. 48 (1961) 47-55.
Bacillus subtilis [GN:bsu], Bacillus cereus
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:14432812]
PIERARD A, WIAME JM.
[Properties of L(d)-alanine dehydrogenase.]
Biochim. Biophys. Acta. 37 (1960) 490-502.
Bacillus subtilis [GN:bsu]
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:14298830]
YOSHIDA A, FREESE E.
ENZYMATIC PROPERTIES OF ALANINE DEHYDROGENASE OF BACILLUS SUBTILIS.
Biochim. Biophys. Acta. 96 (1965) 248-62.
Bacillus subtilis [GN:bsu]
Other DBs ExplorEnz - The Enzyme Database: 1.4.1.1
IUBMB Enzyme Nomenclature: 1.4.1.1
ExPASy - ENZYME nomenclature database: 1.4.1.1
BRENDA, the Enzyme Database: 1.4.1.1
CAS: 9029-06-5
DBGET integrated database retrieval system