| Entry |
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| Name |
ferredoxin---NAD+ reductase;
ferredoxin-nicotinamide adenine dinucleotide reductase;
ferredoxin reductase (ambiguous);
NAD+-ferredoxin reductase;
NADH-ferredoxin oxidoreductase;
reductase, reduced nicotinamide adenine dinucleotide-ferredoxin;
ferredoxin-NAD+ reductase;
NADH-ferredoxin reductase;
NADH2-ferredoxin oxidoreductase;
NADH flavodoxin oxidoreductase;
NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system);
ferredoxin-linked NAD+ reductase;
NADH-ferredoxin TOL reductase (component of toluene dioxygenase);
ferredoxin---NAD reductase
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| Class |
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
ferredoxin:NAD+ oxidoreductase
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| Reaction(IUBMB) |
(1) 2 reduced [2Fe-2S] ferredoxin + NAD+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NADH [RN: R05875];
(2) reduced 2[4Fe-4S] ferredoxin + NAD+ + H+ = oxidized 2[4Fe-4S] ferredoxin + NADH
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| Reaction(KEGG) |
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| Substrate |
reduced [2Fe-2S] ferredoxin;
NAD+ [CPD: C00003];
H+ [CPD: C00080];
reduced 2[4Fe-4S] ferredoxin
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| Product |
oxidized [2Fe-2S] ferredoxin;
NADH [CPD: C00004];
oxidized 2[4Fe-4S] ferredoxin
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| Comment |
Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria.
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| Pathway |
| Fatty acid metabolism | | Xylene degradation |
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| Orthology |
| ferredoxin--NAD+ reductase | | naphthalene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | | xylene monooxygenase electron transfer component | | toluene monooxygenase electron transfer component |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | EOK: | | ELR: | | ECX: | | ECW: | | ECM: | | ECY: | | ECK: | | ECT: | | EOC: | | EUM: | | ELO: | | ELH: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EDH: | | EDJ: | | EUN: | | ELW: | | ELL: | | ELP: | | EBE: | | SFV: | | SFE: | | SSN: | | SSJ: | | PLU: | | PAY: | | ENC: | | EAE: | | KPN: | | KPM: | | SPE: | | PSI: | | XCV: | | XAX: | | PSD: | | FAU: | | VEJ: | | VFU: | | PPF: | | PPX: | | PFS: | | PEN: | | PSC: | | ACI: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | MAQ: | | MBS: | | GAG: | | CYQ: | | CSA: | | ABO: | | GPB: | | RSC: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | PUT: | | RFR: | | POL: | | PNA: | | AJS: | | VEI: | | DAC: | | DEL: | | VAP: | | VPE: | | MPT: | | CFU: | | LCH: | | AZO: | | DAR: | | MLO: | | MCI: | | MOP: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMD: | | RHI: | | SFH: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | BMF: | | BMB: | | BMC: | | BMS: | | BMT: | | BOV: | | BCS: | | BMR: | | OAN: | | BJA: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | AOL: | | XAU: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | BID: | | MSL: | | CCR: | | CCS: | | CAK: | | CSE: | | PZU: | | BSB: | | AEX: | | SIL: | | SIT: | | RSP: | | RSH: | | RSQ: | | RSK: | | RCP: | | JAN: | | RDE: | | PDE: | | DSH: | | KVU: | | KVL: | | MMR: | | HNE: | | HBA: | | NAR: | | NPP: | | SAL: | | SWI: | | SJP: | | ELI: | | AMV: | | AZL: | | ALI: | | ABS: | | TMO: | | PBR: | | APB: | | PGV: | | BTS: | | MTF: | | MTB: | | MBT: | | MVA: | | MGI: | | MAB: | | MMC: | | MKM: | | MJL: | | MMI: | | ASD: | | NFA: | | RHA: | | RER: | | ROP: | | ART: | | AAU: | | MLU: | | NCA: | | SRO: | | FRA: | | FRI: | | FAL: | | ACE: | | NML: | | SEN: | | AMD: | | AMN: | | AMM: | | PDX: | | CAI: | | RXY: | | RSI: | | CAO: | | CLY: | | PHM: | | AVA: | | CCH: | | TRO: | | HMA: | | HWA: | | NPH: | |
» show all
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| Reference |
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| Authors |
Jungermann K, Thauer RK, Leimenstoll G, Decker K. |
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| Title |
Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia. |
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| Journal |
Biochim. Biophys. Acta. 305 (1973) 268-80. |
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| Organism |
Clostridium butyricum, Clostridium pasteurianum |
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| Reference |
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| Authors |
Haigler BE, Gibson DT |
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| Title |
Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816. |
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| Journal |
J. Bacteriol. 172 (1990) 457-64. |
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| Reference |
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| Authors |
Ramachandra M, Seetharam R, Emptage MH, Sariaslani FS |
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| Title |
Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus. |
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| Journal |
J. Bacteriol. 173 (1991) 7106-12. |
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| Reference |
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| Authors |
Shaw JP, Harayama S |
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| Title |
Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2. |
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| Journal |
Eur. J. Biochem. 209 (1992) 51-61. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 39369-37-4 |
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