KEGG   Leishmania major: LMJF_06_0860
Entry
LMJF_06_0860      CDS       T01014                                 
Symbol
DHFR-TS
Name
(RefSeq) dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
lma  Leishmania major
Pathway
lma00240  Pyrimidine metabolism
lma00670  One carbon pool by folate
lma00790  Folate biosynthesis
lma01100  Metabolic pathways
lma01232  Nucleotide metabolism
lma01240  Biosynthesis of cofactors
Module
lma_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:lma00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    LMJF_06_0860 (DHFR-TS)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    LMJF_06_0860 (DHFR-TS)
   00670 One carbon pool by folate
    LMJF_06_0860 (DHFR-TS)
Enzymes [BR:lma01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     LMJF_06_0860 (DHFR-TS)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     LMJF_06_0860 (DHFR-TS)
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 5649109
NCBI-ProteinID: XP_001680857
UniProt: P07382
Position
6:373501..375063
AA seq 520 aa
MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR
AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT
RIYATAPACTRFFPFPPENAATAWDLASSQGRRKSEAEGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVP
HAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgtccagggcagctgcgaggtttaagattccgatgccggagacgaaggcagactttgct
ttcccctccctgcgcgccttctccatcgtcgtggccctcgatatgcagcacggcatcggc
gacggcgagtcgatcccgtggcgggtgccggaggacatgacgttcttcaagaaccagacg
acgctgctgcgcaacaagaagccgccgacggagaagaagcgcaacgccgtcgtgatgggc
cgcaagacttgggagagcgtcccggtaaagttccgaccactcaagggacggctgaacatc
gtgttatcctcgaaggccaccgtcgaggagcttctggcgccgctgccggagggacagcgc
gcggcggcggcgcaggatgtggtggtggtgaacggcggtctggccgaggcgctccgcctc
ctcgcacgcccgctgtactgcagctccatcgagacagcgtattgcgtcggtggtgcgcag
gtttacgcggacgccatgctgtcgccgtgcatcgagaaactgcaggaagtgtacctgacc
cgcatctacgcgacggcgcctgcgtgtacgcgcttctttccgtttccgcccgagaacgcg
gccacggcgtgggacctggcgtcgtctcagggacgccgcaagagcgaggcggagggcctc
gagttcgagatctgcaagtacgtgccgcgcaaccacgaggagcggcagtaccttgagctg
attgaccgcatcatgaagacggggatcgtgaaggaggaccgcaccggcgtgggcaccatc
agcctcttcggcgcccagatgcgcttctccctacgcgacaaccgcctgccgctgctgacg
acgaagcgtgtcttctggcgcggcgtgtgcgaggagctgctgtggttcctgcgcggggag
acgagtgcgcagctgctggcagacaaggacattcacatctgggacggcaacggttcgcgc
gagtttctcgacagccgcggcttgacagagaataaggagatggacctcggccctgtctac
ggcttccagtggcgccacttcggggcagattacaaggggtttgaagcgaactacgacggc
gaaggggtggaccagatcaagctcatcgtggagaccatcaagacgaacccgaacgaccgc
cgcctcctagtcactgcctggaacccgtgcgcgctgcaaaagatggcgctgccgccgtgc
cacttgcttgctcagttctacgtgaacacagacacgagcgagctatcctgcatgttgtac
cagcgctcgtgtgacatgggtcttggcgtccccttcaacattgcctcctacgcgctgctc
accatcctcattgccaaggcgacgggtctgcggcctggtgagcttgtgcacaccctcggc
gacgcccacgtctaccgcaaccacgttgatgccctcaaggcgcagctcgagcgagtcccg
cacgcgttcccgaccctcatcttcaaggaggagcggcagtacctcgaggactacgagttg
acggacatggaggtgatcgactacgttccacacccggcgatcaagatggagatggccgta
tag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (6)   
   KEGG MODULE (3)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (42)   

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