| Entry |
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| Name |
Pentose phosphate pathway
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| Description |
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD: M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD: M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD: M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD: M00008].
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| Class |
Metabolism; Carbohydrate metabolism
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| Pathway map |
| Pentose phosphate pathway |
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| Module |
| Pentose phosphate pathway (Pentose phosphate cycle) [PATH: map00030] | | PRPP biosynthesis, ribose 5P => PRPP [PATH: map00030] | | Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH: map00030] | | Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH: map00030] | | Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH: map00030] | | Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde-3P + pyruvate [PATH: map00030] | | Non-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde + pyruvate [PATH: map00030] | | Pentose phosphate pathway, archaea, fructose 6P => ribose 5P [PATH: map00030] |
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| Disease |
| Phosphoribosylpyrophosphate synthetase I superactivity | | Anemia due to disorders of glutathione metabolism | | Arts syndrome | | Cortisone reductase deficiency (CRD) | | Ribose 5-phosphate isomerase (RPI) deficiency | | Transaldolase (TALDO) deficiency |
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| Other DBs |
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| Reference |
(map 3) |
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| Authors |
Nishizuka Y (ed). |
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| Title |
[Metabolic Maps] (In Japanese) |
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| Journal |
Tokyo Kagaku Dojin (1980) |
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| Reference |
(map 4) |
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| Authors |
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). |
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| Title |
[Cellular Functions and Metabolic Maps] (In Japanese) |
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| Journal |
Tokyo Kagaku Dojin (1997) |
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| Reference |
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| Authors |
Michal G. |
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| Title |
Biochemical Pathways |
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| Journal |
Wiley (1999) |
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| Reference |
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| Authors |
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL. |
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| Title |
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. |
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| Journal |
J Bacteriol 185:2793-801 (2003) |
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| Reference |
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| Authors |
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y |
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| Title |
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis. |
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| Journal |
J Bacteriol 188:4698-704 (2006) |
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| Reference |
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| Authors |
Kato N, Yurimoto H, Thauer RK |
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| Title |
The physiological role of the ribulose monophosphate pathway in bacteria and archaea. |
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| Journal |
Biosci Biotechnol Biochem 70:10-21 (2006) |
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| KO pathway |
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