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Entry
map00350                    Pathway                                

Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Tyrosine metabolism
map00350

All organismsOrtholog table
Module
M00042  
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:map00350]
M00043  
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:map00350]
M00044  
Tyrosine degradation, tyrosine => homogentisate [PATH:map00350]
M00533  
Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:map00350]
Disease
H00163  
Alkaptonuria
H00165  
Tyrosinemia
H00168  
Oculocutaneous albinism (OCA)
H00251  
Thyroid dyshormonogenesis
H00548  
Brunner syndrome
H00831  
Primary dystonia
H01005  
Dopamine beta-hydroxylase deficiency
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
Drug
D03787  
Nepicastat hydrochloride (USAN)
Other DBs
GO: 
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
KO pathway
 

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