| Entry |
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| Name |
Folate biosynthesis
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| Class |
Metabolism; Metabolism of cofactors and vitamins
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| Pathway map |
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| Module |
| Tetrahydrofolate biosynthesis, GTP => THF [PATH: map00790] |
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| Disease |
| Phenylketonuria (PKU) | | Hypophosphatasia | | Primary dystonia | | Dihydrofolate reductase (DHFR) deficiency |
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| Other DBs |
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| Reference |
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| Authors |
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). |
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| Title |
[Cellular Functions and Metabolic Maps] (In Japanese) |
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| Journal |
Tokyo Kagaku Dojin (1997) |
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| Reference |
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| Authors |
Schwarz G, Mendel RR, Ribbe MW |
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| Title |
Molybdenum cofactors, enzymes and pathways. |
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| Journal |
Nature 460:839-47 (2009) |
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| Reference |
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| Authors |
Hanzelmann P, Schindelin H |
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| Title |
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. |
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| Journal |
Proc Natl Acad Sci U S A 103:6829-34 (2006) |
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| Reference |
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| Authors |
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H |
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| Title |
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. |
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| Journal |
Biochemistry 47:615-26 (2008) |
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| Reference |
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| Authors |
Wuebbens MM, Rajagopalan KV |
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| Title |
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. |
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| Journal |
J Biol Chem 278:14523-32 (2003) |
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| KO pathway |
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