KEGG   PATHWAY: map00943Help
Entry
map00943                    Pathway                                

Name
Isoflavonoid biosynthesis
Description
Isoflavonoids are biologically active compounds, such as phytoestrogens, produced by pea family plants. While flavonoids (in the narrow sense) have the 2-phenylchromen-4-one backbone, isoflavonoids have the 3-phenylchromen-4-one backbone with no hydroxyl group substitution at position 2. Isoflavonoids are derived from the flavonoid biosynthesis pathway via liquiritigenin or naringenin.
Class
Metabolism; Biosynthesis of other secondary metabolites
BRITE hierarchy
Pathway map
Isoflavonoid biosynthesis
map00943

All organismsOrtholog table
Reference
  Authors
Latunde-Dada AO, Cabello-Hurtado F, Czittrich N, Didierjean L, Schopfer C, Hertkorn N, Werck-Reichhart D, Ebel J.
  Title
Flavonoid 6-hydroxylase from soybean (Glycine max L.), a novel plant P-450 monooxygenase.
  Journal
J Biol Chem 276:1688-95 (2001)
Reference
  Authors
Baggett BR, Cooper JD, Hogan ET, Carper J, Paiva NL, Smith JT.
  Title
Profiling isoflavonoids found in legume root extracts using capillary electrophoresis.
  Journal
Electrophoresis 23:1642-51 (2002)
Reference
  Authors
Akashi T, Koshimizu S, Aoki T, Ayabe S.
  Title
Identification of cDNAs encoding pterocarpan reductase involved in isoflavan phytoalexin biosynthesis in Lotus japonicus by EST mining.
  Journal
FEBS Lett 580:5666-70 (2006)
Reference
  Authors
Liu CJ, Huhman D, Sumner LW, Dixon RA.
  Title
Regiospecific hydroxylation of isoflavones by cytochrome p450 81E enzymes from Medicago truncatula.
  Journal
Plant J 36:471-84 (2003)
Reference
  Authors
Dhaubhadel S, McGarvey BD, Williams R, Gijzen M.
  Title
Isoflavonoid biosynthesis and accumulation in developing soybean seeds.
  Journal
Plant Mol Biol 53:733-43 (2003)
Reference
  Authors
Shimada N, Akashi T, Aoki T, Ayabe S.
  Title
Induction of isoflavonoid pathway in the model legume Lotus japonicus: molecular characterization of enzymes involved in phytoalexin biosynthesis.
  Journal
Plant Sci 160:37-47 (2000)
Reference
  Authors
Preisig CL, Bell JN, Sun Y, Hrazdina G, Matthews DE, Vanetten HD
  Title
Biosynthesis of the Phytoalexin Pisatin : Isoflavone Reduction and Further Metabolism of the Product Sophorol by Extracts of Pisum sativum.
  Journal
Plant Physiol 94:1444-8 (1990)
Reference
  Authors
Shimada N, Sato S, Akashi T, Nakamura Y, Tabata S, Ayabe S, Aoki T
  Title
Genome-wide analyses of the structural gene families involved in the legume-specific 5-deoxyisoflavonoid biosynthesis of Lotus japonicus.
  Journal
DNA Res 14:25-36 (2007)
Reference
  Authors
Lozovaya VV, Lygin AV, Zernova OV, Ulanov AV, Li S, Hartman GL, Widholm JM.
  Title
Modification of phenolic metabolism in soybean hairy roots through down regulation of chalcone synthase or isoflavone synthase.
  Journal
Planta 225:665-79 (2007)
Reference
  Authors
Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S.
  Title
Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase.
  Journal
Plant J 31:555-64 (2002)
Reference
  Authors
Deavours BE, Dixon RA.
  Title
Metabolic engineering of isoflavonoid biosynthesis in Alfalfa.
  Journal
Plant Physiology 138:2245-2259 (2005)
Reference
  Authors
Hinderer W, Flentje U, Barz W.
  Title
Microsomal isoflavone 2'- and 3'-hydroxylases from chickpea (Cicer arietinum L.) cell suspensions induced for pterocarpan phytoalexin formation.
  Journal
FEBS letters 214(1):101-106 (1987)
Reference
  Authors
Aoki T, Akashi T, Ayabe S.
  Title
Flavonoids of leguminous plants: structure, biological activity, and biosynthesis.
  Journal
Journal of Plant Research 113(4):475-488 (2000)
Reference
  Authors
Barz W, Mackenbrock U.
  Title
Constitutive and elicitation induced metabolism of isoflavones and pterocarpans in chickpea (Cicer arietinum) cell suspension cultures.
  Journal
Plant Cell, Tissue and Organ Culture 38(2-3):199-211 (1994)
Reference
  Authors
Fischer D, Ebenau-Jehle C, Grisebach H.
  Title
Purification and characterization of pterocarpan synthase from elicitor-challenged soybean cell cultures.
  Journal
Phytochemistry 29(9):2879-2882 (1990)
Reference
  Authors
Ayabe S, Akashi T.
  Title
Cytochrome P450s in flavonoid metabolism.
  Journal
Phytochemistry Reviews 5(2-3):271-282 (2006)
Reference
  Authors
Daniel S, Tiemann K, Wittkampf U, Bless W, Hinderer W, Barz W.
  Title
Elicitor-induced metabolic changes in cell cultures of chickpea (Cicer arietinum L.) cultivars resistant and susceptible to Ascochyta rabiei.
  Journal
Planta 182(2):270-278 (1990)
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