KEGG   PATHWAY: map04011Help
Entry
map04011                    Pathway                                

Name
MAPK signaling pathway - yeast
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
MAPK signaling pathway - yeast
map04011

All organismsOrtholog table
Module
M00516  
SLN1-YPD1-SSK1/SKN7 (osmosensing) two-component regulatory system [PATH:map04011]
M00687  
MAPK (ERK1/2) signaling [PATH:map04011]
Other DBs
GO: 
Reference
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003
KO pathway
 

DBGET integrated database retrieval system