KEGG   Macaca mulatta (rhesus monkey): 698569Help
Entry
698569            CDS       T01028                                 

Gene name
MAPK1
Definition
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    698569 (MAPK1)
   04015 Rap1 signaling pathway
    698569 (MAPK1)
   04010 MAPK signaling pathway
    698569 (MAPK1)
   04012 ErbB signaling pathway
    698569 (MAPK1)
   04350 TGF-beta signaling pathway
    698569 (MAPK1)
   04370 VEGF signaling pathway
    698569 (MAPK1)
   04668 TNF signaling pathway
    698569 (MAPK1)
   04066 HIF-1 signaling pathway
    698569 (MAPK1)
   04068 FoxO signaling pathway
    698569 (MAPK1)
   04072 Phospholipase D signaling pathway
    698569 (MAPK1)
   04071 Sphingolipid signaling pathway
    698569 (MAPK1)
   04024 cAMP signaling pathway
    698569 (MAPK1)
   04022 cGMP - PKG signaling pathway
    698569 (MAPK1)
   04151 PI3K-Akt signaling pathway
    698569 (MAPK1)
   04150 mTOR signaling pathway
    698569 (MAPK1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    698569 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    698569 (MAPK1)
   04210 Apoptosis
    698569 (MAPK1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    698569 (MAPK1)
   04520 Adherens junction
    698569 (MAPK1)
   04540 Gap junction
    698569 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    698569 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    698569 (MAPK1)
   04620 Toll-like receptor signaling pathway
    698569 (MAPK1)
   04621 NOD-like receptor signaling pathway
    698569 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    698569 (MAPK1)
   04660 T cell receptor signaling pathway
    698569 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    698569 (MAPK1)
   04662 B cell receptor signaling pathway
    698569 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    698569 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    698569 (MAPK1)
   04062 Chemokine signaling pathway
    698569 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    698569 (MAPK1)
   04912 GnRH signaling pathway
    698569 (MAPK1)
   04915 Estrogen signaling pathway
    698569 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    698569 (MAPK1)
   04917 Prolactin signaling pathway
    698569 (MAPK1)
   04921 Oxytocin signaling pathway
    698569 (MAPK1)
   04919 Thyroid hormone signaling pathway
    698569 (MAPK1)
   04916 Melanogenesis
    698569 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    698569 (MAPK1)
   04270 Vascular smooth muscle contraction
    698569 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    698569 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    698569 (MAPK1)
   04725 Cholinergic synapse
    698569 (MAPK1)
   04726 Serotonergic synapse
    698569 (MAPK1)
   04720 Long-term potentiation
    698569 (MAPK1)
   04730 Long-term depression
    698569 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    698569 (MAPK1)
   04722 Neurotrophin signaling pathway
    698569 (MAPK1)
  Development
   04320 Dorso-ventral axis formation
    698569 (MAPK1)
   04360 Axon guidance
    698569 (MAPK1)
   04380 Osteoclast differentiation
    698569 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    698569 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    698569 (MAPK1)
   05230 Central carbon metabolism in cancer
    698569 (MAPK1)
   05231 Choline metabolism in cancer
    698569 (MAPK1)
   05205 Proteoglycans in cancer
    698569 (MAPK1)
   05203 Viral carcinogenesis
    698569 (MAPK1)
   05210 Colorectal cancer
    698569 (MAPK1)
   05212 Pancreatic cancer
    698569 (MAPK1)
   05214 Glioma
    698569 (MAPK1)
   05216 Thyroid cancer
    698569 (MAPK1)
   05221 Acute myeloid leukemia
    698569 (MAPK1)
   05220 Chronic myeloid leukemia
    698569 (MAPK1)
   05218 Melanoma
    698569 (MAPK1)
   05211 Renal cell carcinoma
    698569 (MAPK1)
   05219 Bladder cancer
    698569 (MAPK1)
   05215 Prostate cancer
    698569 (MAPK1)
   05213 Endometrial cancer
    698569 (MAPK1)
   05224 Breast cancer
    698569 (MAPK1)
   05223 Non-small cell lung cancer
    698569 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    698569 (MAPK1)
   05020 Prion diseases
    698569 (MAPK1)
  Substance dependence
   05034 Alcoholism
    698569 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    698569 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    698569 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    698569 (MAPK1)
   05133 Pertussis
    698569 (MAPK1)
   05152 Tuberculosis
    698569 (MAPK1)
   05164 Influenza A
    698569 (MAPK1)
   05161 Hepatitis B
    698569 (MAPK1)
   05160 Hepatitis C
    698569 (MAPK1)
   05145 Toxoplasmosis
    698569 (MAPK1)
   05140 Leishmaniasis
    698569 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    698569 (MAPK1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    698569 (MAPK1)
   01522 Endocrine resistance
    698569 (MAPK1)
   01524 Platinum drug resistance
    698569 (MAPK1)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     698569 (MAPK1)
Protein kinases [BR:mcc01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   698569 (MAPK1)
Chromosome [BR:mcc03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     698569 (MAPK1)
Exosome [BR:mcc04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   698569 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
10
AA seq 360 aa AA seqDB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtgggaccgcgctacaccaacctctcgtacatcggcgagggtgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagcccctttgag
caccagacctactgccagagaaccctgcgggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgacattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaagacctcatggaaacagatctttacaagctcttgaagacacaacac
ctcagcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatc
cattcagctaacgttctgcaccgtgacctcaagccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggcctggcccgtgttgcagatccagaccatgatcac
acagggttcctgacagaatatgtggctacacgttggtacagggctccagaaattatgttg
aattccaagggctacaccaagtccattgatatttggtctgtaggctgcattctggcagaa
atgctttctaacaggcccatctttccagggaagcattatcttgaccagctgaaccacatt
ctgggtattcttggatccccatcacaagaagacctgaattgtataataaatttaaaagct
aggaactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactccaaagctctggacttactggacaaaatgttgacattcaaccctcacaag
aggattgaagtagaacaggctctggcccacccatatctggagcagtattacgacccgagt
gacgagcccattgccgaagcaccattcaaattcgacatggaattggatgacttgcctaag
gaaaagctcaaagaactaatttttgaagagactgctagattccagccgggatacagatct
taa

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